Lysine methyltransferase 2D regulates pancreatic carcinogenesis through metabolic reprogramming

Marina Koutsioumpa; Maria Hatziapostolou; Christos Polytarchou; Ezequiel J Tolosa; Luciana L Almada; Swapna Mahurkar-Joshi; Jennifer Williams; Ana Belen Tirado-Rodriguez; Sara Huerta-Yepez; Dimitrios Karavias; Helen Kourea; George A Poultsides; Kevin Struhl; David W Dawson; Timothy R Donahue; Martín E Fernández-Zapico; Dimitrios Iliopoulos

doi:10.1136/gutjnl-2017-315690

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Pancreas

Original article

Lysine methyltransferase 2D regulates pancreatic carcinogenesis through metabolic reprogramming

Authors

Marina Koutsioumpa Center for Systems Biomedicine, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA PubMed articles Google scholar articles
Maria Hatziapostolou Biological Sciences, University of Southampton, Southampton, UK Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK PubMed articles Google scholar articles
Christos Polytarchou Interdisciplinary Biomedical Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK PubMed articles Google scholar articles
Ezequiel J Tolosa Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, Minnesota, USA PubMed articles Google scholar articles
Luciana L Almada Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, Minnesota, USA PubMed articles Google scholar articles
Swapna Mahurkar-Joshi Center for Systems Biomedicine, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA PubMed articles Google scholar articles
Jennifer Williams Department of Surgery, Division of General Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA PubMed articles Google scholar articles
Ana Belen Tirado-Rodriguez Unidad de Investigacion en Enfermedades Oncologicas, Hospital Infantil de Mexico, Mexico City, Mexico PubMed articles Google scholar articles
Sara Huerta-Yepez Unidad de Investigacion en Enfermedades Oncologicas, Hospital Infantil de Mexico, Mexico City, Mexico PubMed articles Google scholar articles
Dimitrios Karavias Department of Pathology, School of Medicine, University of Patras, Patras, Greece PubMed articles Google scholar articles
Helen Kourea Department of Pathology, School of Medicine, University of Patras, Patras, Greece PubMed articles Google scholar articles
George A Poultsides Department of Surgery, Stanford University School of Medicine, Stanford, California, USA PubMed articles Google scholar articles
Kevin Struhl Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA PubMed articles Google scholar articles
David W Dawson Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA PubMed articles Google scholar articles
Timothy R Donahue Department of Surgery, Division of General Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA PubMed articles Google scholar articles
Martín E Fernández-Zapico Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, Minnesota, USA PubMed articles Google scholar articles
Dimitrios Iliopoulos Center for Systems Biomedicine, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA PubMed articles Google scholar articles

Correspondence to Dr Dimitrios Iliopoulos, Center for Systems Biomedicine, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles 90095, USA; iliopoulospharma{at}gmail.com

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Citation

Koutsioumpa M, Hatziapostolou M, Polytarchou C, et al

Lysine methyltransferase 2D regulates pancreatic carcinogenesis through metabolic reprogramming

Gut 2019;68:1271-1286.

Publication history

Received November 15, 2017
Revised September 6, 2018
Accepted September 12, 2018
First published October 18, 2018.

Online issue publication

August 21, 2019

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