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Letter
Most unambiguous loss-of-function CPA1 mutations are unlikely to predispose to chronic pancreatitis

https://doi.org/10.1136/gutjnl-2019-318564

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    Footnotes

    • Contributors J-HL, AB and EM performed the functional assay. J-MC, ZL, Z-SL and CF designed the study. J-MC drafted the paper. DNC critically revised the manuscript. All authors analysed the data, contributed to revision of the manuscript and approved the final manuscript.

    • Funding J-HL, a joint PhD student between the Changhai Hospital and INSERM U1078, was in receipt of a 20-month scholarship from the China Scholarship Council (No 201706580018). Support for this study came from the Institut National de la Santé et de la Recherche Médicale (INSERM), the Association des Pancréatites Chroniques Héréditaires, and the Association de Transfusion Sanguine et de Biogénétique Gaetan Saleun, France; the National Natural Science Foundation of China (81470884 and 81770636 (to ZL) and 81873588 (to ZSL)), the Chang Jiang Scholars Program of Ministry of Education (Q2015190 (to ZL)), and the Scientific Innovation Program of Shanghai Municipal Education Committee (to ZL), China.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; internally peer reviewed.

    • Patient consent for publication Not required.