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Prospective colonoscopic study to investigate risk of colorectal neoplasms in first-degree relatives of patients with non-advanced adenomas
  1. Siew C Ng1,2,3,4,
  2. Moe Htet Kyaw2,
  3. Bing Yee Suen2,
  4. Yee Kit Tse2,
  5. Martin C S Wong2,
  6. Aric J Hui5,
  7. Hui Yee Tak6,
  8. James Y W Lau2,7,
  9. Joseph J Y Sung2,4,
  10. Francis K L Chan1,2
  1. 1 Department Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, China
  2. 2 Institute of Digestive Diseases, The Chinese University of Hong Kong, Shatin, China
  3. 3 Li Ka Shing health sciences research institute, The Chinese University of Hong Kong, Hong Kong, China
  4. 4 State Key Laboratory of digestive disease, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, China
  5. 5 Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, China
  6. 6 Department of Medicine, Queen Elizabeth Hospital, Hong Kong, China
  7. 7 Department of Surgery, The Chinese University of Hong Kong, Shatin, China
  1. Correspondence to Professor Siew C Ng, Department of Medicine and Therapeutics, Institute of digestive disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong; siewchienng{at}cuhk.edu.hk

Footnotes

  • Contributors SCN designed and supervised the study. JYWL, AJH and FKLC provided critical input to study design. MHK and SCN performed the colonoscopy procedures and drafted the manuscript. BYS recruited and followed up patients, and collected clinical data. Data analysis was done by BYS and YKT. The manuscript was critically reviewed by SCN, AJH, JYWL, JJYS and FKLC, without editorial support. All authors read, revised and approved the final report.

  • Funding This study was supported by Health and Medical Research Fund (HMRF) in Hong Kong.

  • Disclaimer The funder of the study had no role in study design, data collection, data analysis, data interpretation or writing of the report.

  • Competing interests SCN has served as a consultant to Takeda, Janssen, AbbVie and Ferring. She had been paid lecture fees by Takeda, Janssen, AbbVie, Ferring and Menarini. FKLC has served as a consultant to Eisai, Pfizer, Takeda and Otsuka. He has been paid lecture fees by Eisai, Pfizer, AstraZeneca and Takeda. All other authors have nothing to declare.

  • Ethics approval Clinical Research Ethics Committee of The Chinese University of Hong Kong and New Territories East Cluster of Hospital Authority (Ethical approval number 2015.145; ClinicalTrials.gov number NCT02521727)

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Presented at These data were previously presented at Digestive Disease Week 2017, Chicago.

  • Patient consent for publication Not required.

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Footnotes

  • Contributors SCN designed and supervised the study. JYWL, AJH and FKLC provided critical input to study design. MHK and SCN performed the colonoscopy procedures and drafted the manuscript. BYS recruited and followed up patients, and collected clinical data. Data analysis was done by BYS and YKT. The manuscript was critically reviewed by SCN, AJH, JYWL, JJYS and FKLC, without editorial support. All authors read, revised and approved the final report.

  • Funding This study was supported by Health and Medical Research Fund (HMRF) in Hong Kong.

  • Disclaimer The funder of the study had no role in study design, data collection, data analysis, data interpretation or writing of the report.

  • Competing interests SCN has served as a consultant to Takeda, Janssen, AbbVie and Ferring. She had been paid lecture fees by Takeda, Janssen, AbbVie, Ferring and Menarini. FKLC has served as a consultant to Eisai, Pfizer, Takeda and Otsuka. He has been paid lecture fees by Eisai, Pfizer, AstraZeneca and Takeda. All other authors have nothing to declare.

  • Ethics approval Clinical Research Ethics Committee of The Chinese University of Hong Kong and New Territories East Cluster of Hospital Authority (Ethical approval number 2015.145; ClinicalTrials.gov number NCT02521727)

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Presented at These data were previously presented at Digestive Disease Week 2017, Chicago.

  • Patient consent for publication Not required.

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