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Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma
  1. Man Liu1,2,
  2. Jingying Zhou1,
  3. Xiaoyu Liu1,
  4. Yu Feng1,
  5. Weiqin Yang1,
  6. Feng Wu3,
  7. Otto Ka-Wing Cheung1,
  8. Hanyong Sun4,5,
  9. Xuezhen Zeng1,
  10. Wenshu Tang1,
  11. Myth T S Mok1,
  12. John Wong6,
  13. Philip Chun Yeung6,
  14. Paul Bo San Lai6,
  15. Zhiwei Chen7,
  16. Hongchuan Jin8,
  17. Jie Chen2,
  18. Stephen Lam Chan9,
  19. Anthony W H Chan3,
  20. Ka Fai To3,10,
  21. Joseph J Y Sung4,11,
  22. Minhu Chen2,
  23. Alfred Sze-Lok Cheng1,11
  1. 1 School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
  2. 2 Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China
  3. 3 Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China
  4. 4 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
  5. 5 Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, Shanghai, China
  6. 6 Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China
  7. 7 AIDS Institute, Department of Microbiology and Research Center for Infection and Immunity, The University of Hong Kong, Hong Kong, China
  8. 8 Labortaory of Cancer Biology, Key Laboratory of Biotherapy in Zhejiang, Sir Runrun Shaw hospital, Medical School of Zhejiang University, Hang Zhou, China
  9. 9 Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong, China
  10. 10 State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Hong Kong, China
  11. 11 State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China
  1. Correspondence to Professor Alfred Sze-Lok Cheng, The Chinese University of Hong Kong, Hong Kong, China; alfredcheng{at}cuhk.edu.hk

Footnotes

  • ML and JZ contributed equally.

  • Contributors Study concept and design: ML, JZ and ASLC; Data acquisition and analysis: ML, JZ, XL, YF, WY, FW, HS, XZ, WT, MTSM, AWHC and ASLC; Bioinformatics analysis: FW and OKWC; Clinical resources: JW, PCY, PBSL, ZC, AWHC and KFT; Writing of manuscript: ML, JZ and ASLC; Critical review of manuscript: ML, JZ, PBSL, HJ, JC, SLC, KFT, ZC, JJYS, MC and ASLC; Supervision: ASLC; Funding acquisition: ML, JZ, ZC, JJYS, MC and ASLC.

  • Funding This project is supported by the University Grants Committee through the Collaborative Research Fund (C4045-18W) and the Theme-based Research Scheme (T11-706/18-N), the Health and Medical Research Fund (16170451), the Terry Fox Foundation, the Focused Innovations Scheme-Scheme B (1907309) from the Chinese University of Hong Kong and the Li Ka Shing Foundation (Canada). Man Liu is supported by the China Post-doctoral International Exchange Program and China Postdoctoral Science Foundation.

  • Competing interests None declared.

  • Ethics approval All animal experiments were approved by the Animal Experimentation Ethics Committee of the Chinese University of Hong Kong (AEEC-CUHK). Studies using human specimen were approved by the Joint CUHK-NTEC Clinical Research Ethics Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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Footnotes

  • ML and JZ contributed equally.

  • Contributors Study concept and design: ML, JZ and ASLC; Data acquisition and analysis: ML, JZ, XL, YF, WY, FW, HS, XZ, WT, MTSM, AWHC and ASLC; Bioinformatics analysis: FW and OKWC; Clinical resources: JW, PCY, PBSL, ZC, AWHC and KFT; Writing of manuscript: ML, JZ and ASLC; Critical review of manuscript: ML, JZ, PBSL, HJ, JC, SLC, KFT, ZC, JJYS, MC and ASLC; Supervision: ASLC; Funding acquisition: ML, JZ, ZC, JJYS, MC and ASLC.

  • Funding This project is supported by the University Grants Committee through the Collaborative Research Fund (C4045-18W) and the Theme-based Research Scheme (T11-706/18-N), the Health and Medical Research Fund (16170451), the Terry Fox Foundation, the Focused Innovations Scheme-Scheme B (1907309) from the Chinese University of Hong Kong and the Li Ka Shing Foundation (Canada). Man Liu is supported by the China Post-doctoral International Exchange Program and China Postdoctoral Science Foundation.

  • Competing interests None declared.

  • Ethics approval All animal experiments were approved by the Animal Experimentation Ethics Committee of the Chinese University of Hong Kong (AEEC-CUHK). Studies using human specimen were approved by the Joint CUHK-NTEC Clinical Research Ethics Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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