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Original article
Mortality in adult-onset and elderly-onset IBD: a nationwide register-based cohort study 1964–2014
  1. Ola Olén1,2,3,
  2. Johan Askling1,
  3. Michael C Sachs1,
  4. Martin Neovius1,
  5. Karin E Smedby1,
  6. Anders Ekbom1,
  7. Jonas F Ludvigsson4,5,6,7
  1. 1Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
  2. 2Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden
  3. 3Sachs’ Children and Youth Hospital, Stockholm South General Hospital, Stockholm, Sweden
  4. 4Department of Pediatrics, Örebro University Hospital, Örebro, Sweden
  5. 5Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
  6. 6Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK
  7. 7Department of Medicine, Columbia University College of Physicians and Surgeons, New York, USA
  1. Correspondence to Dr Ola Olén, Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm 17176, Sweden; ola.olen{at}ki.se

Footnotes

  • Contributors Guarantor: OO had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: OO, JFL, JA, MCS. Acquisition of data: OO. Analysis: MCS, OO, JFL. Interpretation of data: OO, JA, MCS, MN, KES, AE, JFL. Drafting of the manuscript: JFL, OO, MCS. Critical revision of the manuscript for important intellectual content and approval of final version: OO, JA, MCS, MN, KES, AE, JFL.

  • Funding OO was supported by grants from the Swedish Medical Society (Project grants SLS-789611)), Swedish Foundation for Strategic Research, and Regional Agreement on Medical Training and Clinical Research between Stockholm County Council and Karolinska Institutet (ALF, 20170720, 20170424). JA was supported by the Swedish Cancer Society, the Stockholm County Council (ALF), the Swedish Research Council and the Swedish Foundation for Strategic Research during the conduct of the study. JFL was supported by the FORTE Foundation (83278) and the Swedish Cancer Foundation. None of the funding organisations had any role in the design and conduct of the study; in the collection, management, and analysis of the data; or in the preparation, review and approval of the manuscript.

  • Competing interests OO has been principal investigator (PI) on projects at Karolinska Institutet partly financed by investigator-initiated grants from Janssen, Ferring, Takeda and Pfizer. None of those studies have any relation to the present study. Karolinska Institutet has received fees for lectures and participation on advisory boards from Janssen, Ferring, Takeda and Pfizer regarding topics not related to the present study. JA reports grants from AbbVie, Bristol-Myers Squibb, Lilly, Merck, Pfizer, Roche, Samsung Bioepis and UCB, mainly in the context of a national safety monitoring programme for immunomodulators in rheumatology (ARTIS). JFL coordinates a study unrelated to the present study on behalf of the Swedish IBD Quality Register (SWIBREG). That study has received funding from Janssen. KES has been PI for research projects partly financed by unrestricted grants from Janssen pharmaceutical to Karolinska Institutet. MN has been PI for research projects unrelated to the current paper and partly financed by investigator-initiated grants from Pfizer and Astra Zeneca to Karolinska Institutet, and has received fees for participation in advisory boards (related to rheumatology). Other authors disclosed no conflicts of interest.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data available due to Swedish regulation.

  • Author note Several of the researchers care for patients with IBD in their clinical work. The questions addressed in this paper are based on what patients usually want to know. However, in this register-based study no patients were directly involved in the design, recruitment or conduct of the study.

  • Patient consent for publication Not required.

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Footnotes

  • Contributors Guarantor: OO had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: OO, JFL, JA, MCS. Acquisition of data: OO. Analysis: MCS, OO, JFL. Interpretation of data: OO, JA, MCS, MN, KES, AE, JFL. Drafting of the manuscript: JFL, OO, MCS. Critical revision of the manuscript for important intellectual content and approval of final version: OO, JA, MCS, MN, KES, AE, JFL.

  • Funding OO was supported by grants from the Swedish Medical Society (Project grants SLS-789611)), Swedish Foundation for Strategic Research, and Regional Agreement on Medical Training and Clinical Research between Stockholm County Council and Karolinska Institutet (ALF, 20170720, 20170424). JA was supported by the Swedish Cancer Society, the Stockholm County Council (ALF), the Swedish Research Council and the Swedish Foundation for Strategic Research during the conduct of the study. JFL was supported by the FORTE Foundation (83278) and the Swedish Cancer Foundation. None of the funding organisations had any role in the design and conduct of the study; in the collection, management, and analysis of the data; or in the preparation, review and approval of the manuscript.

  • Competing interests OO has been principal investigator (PI) on projects at Karolinska Institutet partly financed by investigator-initiated grants from Janssen, Ferring, Takeda and Pfizer. None of those studies have any relation to the present study. Karolinska Institutet has received fees for lectures and participation on advisory boards from Janssen, Ferring, Takeda and Pfizer regarding topics not related to the present study. JA reports grants from AbbVie, Bristol-Myers Squibb, Lilly, Merck, Pfizer, Roche, Samsung Bioepis and UCB, mainly in the context of a national safety monitoring programme for immunomodulators in rheumatology (ARTIS). JFL coordinates a study unrelated to the present study on behalf of the Swedish IBD Quality Register (SWIBREG). That study has received funding from Janssen. KES has been PI for research projects partly financed by unrestricted grants from Janssen pharmaceutical to Karolinska Institutet. MN has been PI for research projects unrelated to the current paper and partly financed by investigator-initiated grants from Pfizer and Astra Zeneca to Karolinska Institutet, and has received fees for participation in advisory boards (related to rheumatology). Other authors disclosed no conflicts of interest.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data available due to Swedish regulation.

  • Author note Several of the researchers care for patients with IBD in their clinical work. The questions addressed in this paper are based on what patients usually want to know. However, in this register-based study no patients were directly involved in the design, recruitment or conduct of the study.

  • Patient consent for publication Not required.

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