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Original article
Donor metabolic characteristics drive effects of faecal microbiota transplantation on recipient insulin sensitivity, energy expenditure and intestinal transit time
  1. Pieter de Groot1,
  2. Torsten Scheithauer1,
  3. Guido J Bakker1,
  4. Andrei Prodan1,
  5. Evgeni Levin1,
  6. Muhammad Tanweer Khan2,
  7. Hilde Herrema1,
  8. Mariette Ackermans1,
  9. Mireille J M Serlie1,
  10. Maurits de Brauw3,
  11. Johannes H M Levels1,
  12. Amber Sales1,
  13. Victor E Gerdes1,
  14. Marcus Ståhlman2,
  15. Alinda W M Schimmel1,
  16. Geesje Dallinga-Thie1,
  17. Jacques JGHM Bergman4,
  18. Frits Holleman1,
  19. Joost B L Hoekstra1,
  20. Albert Groen1,
  21. Fredrik Bäckhed2,
  22. Max Nieuwdorp1
  1. 1Department of Internal and Vascular Medicine, Amsterdam University Medical Centres, Amsterdam, The Netherlands
  2. 2Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, Goteborgs Universitet, Gothenburg, Sweden
  3. 3Department of Surgery, Spaarne Gasthuis, Haarlem, The Netherlands
  4. 4Department of Gastroenterology, Amsterdam University Medical Centres, Amsterdam, The Netherlands
  1. Correspondence to Dr Max Nieuwdorp, Department of Internal and Vascular Medicine, Amsterdam University Medical Centres, Amsterdam 1105 AZ, The Netherlands; m.nieuwdorp{at}amc.nl

Footnotes

  • Contributors PdG, GJB, AS performed the patient visits. TS, MTK, HH, MA, MS, JHML, AWMS, GD-T, MJS performed the wet lab analyses. PdG, AP, EL performed the data analyses. MdB was involved in the recruitment of bariatric surgery subjects. JJGHMB was involved in performing the gastroduodenoscopies. PdG, MN drafted the manuscript. FH, JBLH, AG, FB, MN supervised the project. All authors critically appraised the manuscript and the revised manuscript.

  • Funding MN is supported by a ZONMW-VIDI grant 2013 (016.146.327), a Dutch Heart Foundation CVON IN CONTROL Young Talent Grant 2013 and a JPl HDHL MICRODIET project (50-52905-98-620). FB is Torsten Söderberg professor in medicine and recipient of a European Research Council Consolidator Grant (615362 - METABASE). The study reported here was additionally supported by Leducq consortium grant 17CVD01 and Novo Nordisk Foundation GUT-MMM grant 2016.

  • Competing interests MN is in the Scientific Advisory Board of Caelus Pharmaceuticals, the Netherlands. FB is in the Scientific Advisory Board of MetaboGen, Sweden.

  • Ethics approval The study was approved by the local institutional review board of the Academic Medical Centre (AMC) in Amsterdam, The Netherlands and conducted at the AMC in accordance with the Declaration of Helsinki.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Not required.

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Footnotes

  • Contributors PdG, GJB, AS performed the patient visits. TS, MTK, HH, MA, MS, JHML, AWMS, GD-T, MJS performed the wet lab analyses. PdG, AP, EL performed the data analyses. MdB was involved in the recruitment of bariatric surgery subjects. JJGHMB was involved in performing the gastroduodenoscopies. PdG, MN drafted the manuscript. FH, JBLH, AG, FB, MN supervised the project. All authors critically appraised the manuscript and the revised manuscript.

  • Funding MN is supported by a ZONMW-VIDI grant 2013 (016.146.327), a Dutch Heart Foundation CVON IN CONTROL Young Talent Grant 2013 and a JPl HDHL MICRODIET project (50-52905-98-620). FB is Torsten Söderberg professor in medicine and recipient of a European Research Council Consolidator Grant (615362 - METABASE). The study reported here was additionally supported by Leducq consortium grant 17CVD01 and Novo Nordisk Foundation GUT-MMM grant 2016.

  • Competing interests MN is in the Scientific Advisory Board of Caelus Pharmaceuticals, the Netherlands. FB is in the Scientific Advisory Board of MetaboGen, Sweden.

  • Ethics approval The study was approved by the local institutional review board of the Academic Medical Centre (AMC) in Amsterdam, The Netherlands and conducted at the AMC in accordance with the Declaration of Helsinki.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Not required.

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