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Original article
Kras and Lkb1 mutations synergistically induce intraductal papillary mucinous neoplasm derived from pancreatic duct cells
  1. Louis Collet1,
  2. Elsa Ghurburrun1,
  3. Nora Meyers1,
  4. Mohamad Assi1,
  5. Boris Pirlot2,
  6. Isabelle A Leclercq2,
  7. Anne Couvelard3,4,
  8. Mina Komuta5,
  9. Jérôme Cros6,
  10. Pieter Demetter7,
  11. Frédéric P Lemaigre1,
  12. Ivan Borbath2,8,
  13. Patrick Jacquemin1
  1. 1 Université catholique de Louvain, de Duve Institute, Brussels, Belgium
  2. 2 Université catholique de Louvain, IREC, Brussels, Belgium
  3. 3 Université Paris Diderot, U1149, Paris, France
  4. 4 Hôpital Bichat, Department of Pathology, AP-HP, DHU UNITY, Paris, France
  5. 5 Université catholique de Louvain, Cliniques universitaires Saint- Luc, Department of Pathology, Brussels, Belgium
  6. 6 Hôpital Beaujon, Department of Pathology, INSERM U1149, Paris, France
  7. 7 Université libre de Bruxelles, Erasme University Hospital, Department of Pathology, Brussels, Belgium
  8. 8 Université catholique de Louvain, Cliniques universitaires Saint-Luc, Brussels, Belgium
  1. Correspondence to Dr Ivan Borbath, Université catholique de Louvain ,Cliniques universitaires Saint-Luc, Hepato-Gastroenterology unit, Avenue Hippocrate 10, B-1200 Brussels, Belgium; ivan.borbath{at}uclouvain.be and Dr Patrick Jacquemin, de Duve Institute, Université catholique de Louvain, Brussels B-1200, Belgium; patrick.jacquemin{at}uclouvain.be

Footnotes

  • LC and EG contributed equally.

  • Contributors Acquisition and statistical analysis of data: LC, EG. Analysis and interpretation of data: LC, EG, AC, IB, PJ. Provision of material: MK, PD. Drafting the manuscript: PJ, LC, EG. Revision of the manuscript: LC, EG, AC, PD, IB, FL, PJ.

  • Funding This work was supported by grants from the Fondation contre le Cancer (Belgium #2014-125 and #2018-078 to FL, and #2016-089 and #2018-076 to PJ), the FRS-FNRS (Belgium; #T007214 to FL and #J002517 to PJ), the Université catholique de Louvain, the Centre du Cancer (Cliniques universitaires St-Luc), the Fonds Maisin, and the COST Action BM1204 EU_Pancreas. LC, EG and NM hold a Télévie fellowship (#74600115 and #7651017).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Author note PJ is senior research associate at the FRS-FNRS (Belgium).

  • Patient consent for publication Not required.

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Footnotes

  • LC and EG contributed equally.

  • Contributors Acquisition and statistical analysis of data: LC, EG. Analysis and interpretation of data: LC, EG, AC, IB, PJ. Provision of material: MK, PD. Drafting the manuscript: PJ, LC, EG. Revision of the manuscript: LC, EG, AC, PD, IB, FL, PJ.

  • Funding This work was supported by grants from the Fondation contre le Cancer (Belgium #2014-125 and #2018-078 to FL, and #2016-089 and #2018-076 to PJ), the FRS-FNRS (Belgium; #T007214 to FL and #J002517 to PJ), the Université catholique de Louvain, the Centre du Cancer (Cliniques universitaires St-Luc), the Fonds Maisin, and the COST Action BM1204 EU_Pancreas. LC, EG and NM hold a Télévie fellowship (#74600115 and #7651017).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Author note PJ is senior research associate at the FRS-FNRS (Belgium).

  • Patient consent for publication Not required.

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