Article Text

Download PDFPDF
Letter
Absence of hepatitis E virus RNA in semen samples of infertile male in China
  1. Lin Wang1,
  2. Zhe Zhang2,3,
  3. Jingyi Shu1,
  4. Haitao Zhang2,3,
  5. Yuzhuo Yang2,3,
  6. Zhaochao Liang1,
  7. Qiyu He1,
  8. Weijin Huang4,
  9. Youchun Wang4,
  10. Hui Zhuang1,
  11. Hui Jiang2,3,
  12. Ling Wang1
  1. 1 Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
  2. 2 Department of Urology, Peking University Third Hospital, Beijing, China
  3. 3 Department of Reproductive Medicine Center, Peking University Third Hospital, Beijing, China
  4. 4 Division of HIV/AIDS and Sexually Transmitted Virus Vaccines, National Institutes for Food and Drug Control, Beijing, China
  1. Correspondence to Dr Hui Jiang, Department of Urology, Peking university Third Hospital, Beijing 100191, China; jianghui55pku{at}163.com and Dr Ling Wang, Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Beijing 100191, China; lingwang{at}bjmu.edu.cn

Statistics from Altmetric.com

Hepatitis E virus (HEV) RNA has been recently discovered in semen samples of Chinese infertile man with a remarkably high rate of 28.1% (52/185, table 1).1 All HEV isolates belong to HEV genotype 4 (HEV4), which is the dominant strain prevalent in China. This intriguing discovery has aroused our attention. In a recent response to the work done by Huang et al, researchers in Germany tested 87 semen samples collected from infertile men, but the HEV RNA positive rate is 0% (table 1).2 Germany is prevalent with HEV3, so the authors suggested that HEV genotype-specific or variant-specific pathophysiology may explain the contrary results. However, the two studies both have limitations to reach a more accurate conclusion. The size of patients included in both studies is relatively small, and …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.