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Loss of Setd2 promotes Kras-induced acinar-to-ductal metaplasia and epithelia–mesenchymal transition during pancreatic carcinogenesis

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  • NN and PL contributed equally.

  • Contributors JX, NN and PL designed experiment and interpreted data; NN and PL performed most of the experiments; YY, RH, JS, JW, MY and LZ assisted in some experiments; L-WW, W-QG and ZZ provided the key materials; ZZ, GGX and AH assisted in some discussion; JX and NN wrote the manuscript; JX, LL and YS provided the overall guidance.

  • Funding This work was supported by Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning No TP2015007 (JX); Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support No 20161312 (JX); The Shanghai Youth Talent Support Program (JX); Shanghai Rising-Star Program No 19QA1408300 (NN); The Science and Technology Commission of Shanghai Municipality No 18140902700 and No 19140905500 (LL); State Key Laboratory of Oncogenes and Related Genes No KF01801 (LL); Innovation Research Plan supported by Shanghai Municipal Education Commission No ZXGF082101 (LL); National Natural Science Foundation of China No 81702938 and No 81770628 (JX), No 81772938 (LL), No 81802307 (PL), No 81874175 (YS) and No 81802317 (MY).

  • Competing interests None declared.

  • Ethics approval All protocols for animal use and euthanasia were reviewed and approved by RenJi Hospital Institutional Animal Care and Ethics Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Not required.

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Footnotes

  • NN and PL contributed equally.

  • Contributors JX, NN and PL designed experiment and interpreted data; NN and PL performed most of the experiments; YY, RH, JS, JW, MY and LZ assisted in some experiments; L-WW, W-QG and ZZ provided the key materials; ZZ, GGX and AH assisted in some discussion; JX and NN wrote the manuscript; JX, LL and YS provided the overall guidance.

  • Funding This work was supported by Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning No TP2015007 (JX); Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support No 20161312 (JX); The Shanghai Youth Talent Support Program (JX); Shanghai Rising-Star Program No 19QA1408300 (NN); The Science and Technology Commission of Shanghai Municipality No 18140902700 and No 19140905500 (LL); State Key Laboratory of Oncogenes and Related Genes No KF01801 (LL); Innovation Research Plan supported by Shanghai Municipal Education Commission No ZXGF082101 (LL); National Natural Science Foundation of China No 81702938 and No 81770628 (JX), No 81772938 (LL), No 81802307 (PL), No 81874175 (YS) and No 81802317 (MY).

  • Competing interests None declared.

  • Ethics approval All protocols for animal use and euthanasia were reviewed and approved by RenJi Hospital Institutional Animal Care and Ethics Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Not required.

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