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We read with great interest the paper by Gerbes et al 1 summarising recent advances in the treatment of hepatocellular carcinoma (HCC), and that by De Toni et al 2 reporting the importance of early diagnosis for survival of HCC. As these papers suggest, early HCC diagnosis needs to be improved, and the use of MRI for diagnosing HCC is increasing.
Contrary to most other cancers, a non-invasive diagnosis based on imaging characteristics without mandatory pathological confirmation is acceptable for HCC.3–5 However, previous major guidelines have lacked exact definitions of the imaging diagnostic criteria for HCC.6 This could be more problematic for MRI, which provides multiparametric information from complex MRI sequences. To standardise the imaging interpretation of lesions in patients at risk of HCC, the Liver Imaging Reporting and Data System (LI-RADS) was introduced in 2011,6 updated in 2018,7 and fully integrated into the American …
Contributors SHC contributed to study concept and design. SHC and DHK acquired, analysed and interpreted the data. DHK and SHC drafted the manuscript. DHK, SHP and KWK performed statistical analysis. JHB, SYK, SSL, YMS, HJW and PNK made critical revisions to the manuscript. SHC and JHB supervised the study.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
Patient consent for publication Not required.