Article info

Download PDFPDF

Original article
Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma

Authors

  • Jiabin Cai Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University & Ministry of Education, Shanghai, China Key Laboratory of Medical Epigenetics and Metabolism, Institute of Biomedical Sciences, Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Lei Chen The International Cooperation Laboratory on Signal Transduction, The Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China National Center for Liver Cancer, Shanghai, China PubMed articlesGoogle scholar articles
  • Zhou Zhang Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA PubMed articlesGoogle scholar articles
  • Xinyu Zhang Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University & Ministry of Education, Shanghai, China PubMed articlesGoogle scholar articles
  • Xingyu Lu Shanghai Epican Genetech Co. Ltd., Shanghai, China PubMed articlesGoogle scholar articles
  • Weiwei Liu Department of Laboratory Medicine, The Tenth People’s Hospital of Shanghai, Tongji University, Shanghai, China PubMed articlesGoogle scholar articles
  • Guoming Shi Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University & Ministry of Education, Shanghai, China PubMed articlesGoogle scholar articles
  • Yang Ge School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China PubMed articlesGoogle scholar articles
  • Pingting Gao Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University & Ministry of Education, Shanghai, China PubMed articlesGoogle scholar articles
  • Yuan Yang Department of Hepatobiliary Surgery, The Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China PubMed articlesGoogle scholar articles
  • Aiwu Ke Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University & Ministry of Education, Shanghai, China PubMed articlesGoogle scholar articles
  • Linlin Xiao Department of Laboratory Medicine, Shanghai Jiao Tong University, Shanghai, China PubMed articlesGoogle scholar articles
  • Ruizhao Dong Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University & Ministry of Education, Shanghai, China PubMed articlesGoogle scholar articles
  • Yanjing Zhu The International Cooperation Laboratory on Signal Transduction, The Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China PubMed articlesGoogle scholar articles
  • Xuan Yang Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University & Ministry of Education, Shanghai, China PubMed articlesGoogle scholar articles
  • Jiefei Wang Shanghai Public Health Clinic Center, Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Tongyu Zhu Shanghai Public Health Clinic Center, Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Deping Yang Department of Laboratory Medicine, Zhoupu Hospital, Shanghai University of Medicine & Health Sciences, Shanghai, China PubMed articlesGoogle scholar articles
  • Xiaowu Huang Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University & Ministry of Education, Shanghai, China PubMed articlesGoogle scholar articles
  • Chengjun Sui Department of Hepatobiliary Surgery, The Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China PubMed articlesGoogle scholar articles
  • Shuangjian Qiu Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University & Ministry of Education, Shanghai, China PubMed articlesGoogle scholar articles
  • Feng Shen Department of Hepatobiliary Surgery, The Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China PubMed articlesGoogle scholar articles
  • Huichuan Sun Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University & Ministry of Education, Shanghai, China PubMed articlesGoogle scholar articles
  • Weiping Zhou Department of Hepatobiliary Surgery, The Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China PubMed articlesGoogle scholar articles
  • Jian Zhou Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University & Ministry of Education, Shanghai, China Key Laboratory of Medical Epigenetics and Metabolism, Institute of Biomedical Sciences, Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Ji Nie Department of Chemistry, University of Chicago, Chicago, Illinois, USA PubMed articlesGoogle scholar articles
  • Chang Zeng Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA Driskill Graduate Program in Life Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, Chicago PubMed articlesGoogle scholar articles
  • Emily Kunce Stroup Driskill Graduate Program in Life Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, Chicago PubMed articlesGoogle scholar articles
  • Xu Zhang Department of Medicine, University of Illinois, Chicago, Illinois, USA PubMed articlesGoogle scholar articles
  • Brian C-H Chiu Department of Public Health Sciences, University of Chicago, Chicago, Illinois, USA PubMed articlesGoogle scholar articles
  • Wan Yee Lau Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong, China PubMed articlesGoogle scholar articles
  • Chuan He Department of Chemistry, University of Chicago, Chicago, Illinois, USA Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, USA Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois, USA The Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois, USA PubMed articlesGoogle scholar articles
  • Hongyang Wang The International Cooperation Laboratory on Signal Transduction, The Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China National Center for Liver Cancer, Shanghai, China Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer, The Second Military Medical University & Ministry of Education, Shanghai, China PubMed articlesGoogle scholar articles
  • Wei Zhang Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA PubMed articlesGoogle scholar articles
  • Jia Fan Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University & Ministry of Education, Shanghai, China Key Laboratory of Medical Epigenetics and Metabolism, Institute of Biomedical Sciences, Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Chuan He, Department of Chemistry, University of Chicago, Chicago, Illinois 60637, USA; chuanhe{at}uchicago.edu, Dr Hongyang Wang, The International Cooperation Laboratory on Signal Transduction, The Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai 200433, China; hywangk{at}vip.sina.com, Dr Wei Zhang, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA; wei.zhang1{at}northwestern.edu and Dr Jia Fan, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China; fan.jia{at}zs-hospital.sh.cn
View Full Text

Citation

Cai J, Chen L, Zhang Z, et al
Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma

Publication history

  • Received April 11, 2019
  • Revised June 3, 2019
  • Accepted June 21, 2019
  • First published July 29, 2019.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.