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With great interest we read the review article of Iacucci et al on advanced endoscopic techniques in IBD.1 The authors clearly recognise the current limitations of the different endoscopic scoring tools for disease activity in IBD and provide potential solutions with new advanced techniques. We fully agree that interobserver variability is problematic for treatment planning and IBD drug development and we lack objective definitions of endoscopic remission that predict further disease course in both Crohn’s disease and ulcerative colitis (UC). Scoring systems were mostly developed at the end of the previous century, based on evaluations with fiberoptic endoscopes or poor quality white light video-endoscopes. Intrinsically, it could be anticipated that by seeing more details and nuances such as with virtual chromo-endoscopy, this could result in a superior assessment of the disease activity in IBD. …
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