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Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting
  1. Matias A Avila1,
  2. Jean-François Dufour2,
  3. Alexander L Gerbes3,
  4. Fabien Zoulim4,
  5. Ramon Bataller5,
  6. Patrizia Burra6,
  7. Helena Cortez-Pinto7,
  8. Bin Gao8,
  9. Ian Gilmore9,
  10. Philippe Mathurin10,
  11. Christophe Moreno11,
  12. Vladimir Poznyak12,
  13. Bernd Schnabl13,
  14. Gyongyi Szabo14,
  15. Maja Thiele15,
  16. Mark R Thursz16
  1. 1Hepatology, CIBERehd, IdiSNA, CIMA, University of Navarra, Pamplona, Spain
  2. 2Hepatology, Department of Clinical Research and University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern, Bern, Switzerland
  3. 3Liver Centre Munich, Department of Medicine II, University Hospital, LMU Munich, Munich, Germany
  4. 4Hepatology Department, INSERM U1052, Hospices Civils de Lyon, Cancer Research Centerl of Lyon, University of Lyon, Lyon, France
  5. 5Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
  6. 6Multivisceral Transplant Unit, Gastroenterology, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy
  7. 7Departamento de Gastroenterologia, CHLN, Laboratorio de Nutriçao, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
  8. 8Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
  9. 9Liverpool Centre for Alcohol Research, University of Liverpool, Liverpool, UK
  10. 10Service des Maladies de l'Appareil Digestif, INSERM U795, Hôpital Huriez, Lille, France
  11. 11Service de Gastroentérologie, Hépatopancréatologie et Oncologie Digestive, CUB Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium
  12. 12Department of Mental Health and Substance Abuse, World Health Organization, Geneve, Switzerland
  13. 13Department of Medicine, University of California San Diego, La Jolla, California, USA
  14. 14Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
  15. 15Department of Gastroenterology and Hepatology, and Department of Clinical Research, Odense University Hospital and University of Southern Denmark, Odense, Denmark
  16. 16Department of Metabolism, Faculty of Medicine, Imperial College, London, UK
  1. Correspondence to Professor Matias A Avila, Hepatology, CIMA-University of Navarra, Pamplona, Spain; maavila{at}unav.es

Abstract

Alcohol-related liver disease (ALD), which includes a range of disorders of different severity and is one of the most prevalent types of liver disease worldwide, has recently regained increased attention. Among other reasons, the realisation that any alcohol intake, regardless of type of beverage represents a health risk, and the new therapeutic strategies tested in recently published or undergoing clinical trials spur scientific interest in this area.

In April 2019, Gut convened a round table panel of experts during the European Association for the Study of the Liver International Liver Congress in Vienna to discuss critical and up-to-date issues and clinical trial data regarding ALD, its epidemiology, diagnosis, management, pathomechanisms, possible future treatments and prevention. This paper summarises the discussion and its conclusions.

  • alcoholic liver disease
  • alcohol
  • fibrosis
  • cirrhosis
  • liver transplantation
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Footnotes

  • Twitter @dufour_jf

  • Contributors All authors have contributed and reviewed the manuscript.

  • Funding The event was solely funded by Gut.

  • Patient consent for publication Not required.

  • Provenance and peer review Commissioned; externally peer reviewed.

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