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Effects of high-fat diet-induced gut microbiota dysbiosis: far beyond the gut
  1. Tianyu Liu,
  2. Bangmao Wang,
  3. Hailong Cao
  1. Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China
  1. Correspondence to Dr Hailong Cao, Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, 300052 Tianjin, China; caohailong{at}tmu.edu.cn; Dr Bangmao Wang; mwang02{at}tmu.edu.cn

https://doi.org/10.1136/gutjnl-2020-320717

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    We read with great interest the attractive study by Ding N et al,1 which reported that the dysbiosis of gut microbiota induced by high-fat diet (HFD) was one of the primary causes for the impaired sperm production and motility. It is likely mediated by elevated blood endotoxin, epididymal inflammation and the dysregulation of testicular gene expressions. We commend the authors for such a rigorous work on this critical issue. We would like to raise several concerns about this study.

    According to the data in this study, metagenomic sequencing may be needed to further explore the mechanisms by which certain key bacteria disrupt spermatogenesis and sperm motility. Moreover, whether probiotics supplementation can modulate gut microbiota and improve spermatogenesis and sperm motility are also worthy of exploration.

    Faecal microbiota transplantation (FMT) was performed in this study. …

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    Footnotes

    • Contributors All the authors contributed with their comments and suggestions to the preparation of this paper and all of them reviewed and approved the final version of this manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Provenance and peer review Not commissioned; externally peer reviewed.

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      Ning Ding Fang Hong Li Bing Yao Yun Ping Mu Allan Z. Zhao
      Gut 2020; 69 2259-2260 Published Online First: 10 Apr 2020. doi: 10.1136/gutjnl-2020-321220