Article Text

Download PDFPDF
Effect of ACE inhibitors and angiotensin II receptor blockers on disease outcomes in inflammatory bowel disease
  1. Keeley M Fairbrass1,
  2. Deloar Hoshen1,
  3. David J Gracie2,
  4. Alexander C Ford1
  1. 1Leeds Gastroenterology Institute, St James's University Hospital, Leeds, UK
  2. 2Leeds Gastroenterology Institute, Leeds Teaching Hospitals NHS Trust, Leeds, UK
  1. Correspondence to Professor Alexander C Ford, Leeds Gastroenterology Institute, St. James's University Hospital, Leeds LS9 7TF, UK; alexf12399{at}

Statistics from

We read the recent paper by Garg et al1 with interest. The renin-angiotensin system (RAS) has an established role in the pathogenesis of fibrosis and inflammation in renal and cardiovascular disease. However, high concentrations of ACE and renin are also found in the small and large intestines. These, along with angiotensin II, are elevated further within the inflamed colonic tissue of patients with IBD, compared with healthy controls.1 2 ACE inhibitor (ACE-I) or angiotensin II receptor blocker (ARB) therapy may inhibit the effects of RAS in IBD. In their study Garg et al1 demonstrated lower rates of hospitalisation and surgery among patients with IBD receiving these drugs. We aimed to examine the relationship between ACE-I …

View Full Text


  • Contributors DJG and ACF conceived and drafted the study. DJG, KMF and DH collected all data. DJG and ACF analysed and interpreted the data. KMF drafted the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; internally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.