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Contributors MC conceived the idea and drafted the manuscript and revised and finalised the manuscript. He is the senior author. VC is the co-author. He was involved in revision and finalising of the manuscript.
Funding MC research work is supported by grants R01-DK115950 and R01- DK122280 from National Institutes of Health. MC is the guarantor of the manuscript, taking responsibility for its accuracy, having access to all of the data and having the decision to publish the paper.
Competing interests MC has received research support for proof of concept single centre or multicentre studies from Allergan, Bird Rock Bio, Novartis and Takeda.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; externally peer reviewed.