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Hepatology
Original research
Three-dimensional bioprinted hepatorganoids prolong survival of mice with liver failure

Authors

  • Huayu Yang Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC & Chinese Academy of Medical Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Lejia Sun Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC & Chinese Academy of Medical Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Yuan Pang Biomanufacturing Center, Department of Mechanical Engineering, Tsinghua University, Beijing, China Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing, Tsinghua University, Beijing, China Overseas Expertise Introduction Center for Discipline Innovation, Tsinghua University, Beijing, China PubMed articlesGoogle scholar articles
  • Dandan Hu Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC & Chinese Academy of Medical Sciences, Beijing, China Department of Hepatobiliary Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Haifeng Xu Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC & Chinese Academy of Medical Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Shuangshuang Mao Biomanufacturing Center, Department of Mechanical Engineering, Tsinghua University, Beijing, China Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing, Tsinghua University, Beijing, China Overseas Expertise Introduction Center for Discipline Innovation, Tsinghua University, Beijing, China PubMed articlesGoogle scholar articles
  • Wenbo Peng School of Life Science and Technology, ShanghaiTech University, Shanghai, China PubMed articlesGoogle scholar articles
  • Yanan Wang State Key Laboratory of Medical Molecular Biology, Department of Physiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China PubMed articlesGoogle scholar articles
  • Yiyao Xu Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC & Chinese Academy of Medical Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Yong-Chang Zheng Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC & Chinese Academy of Medical Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Shunda Du Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC & Chinese Academy of Medical Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Haitao Zhao Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC & Chinese Academy of Medical Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Tianyi Chi Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC & Chinese Academy of Medical Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Xin Lu Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC & Chinese Academy of Medical Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Xinting Sang Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC & Chinese Academy of Medical Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Shouxian Zhong Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC & Chinese Academy of Medical Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Xin Wang Research Center for Laboratory Animal Science, Inner Mongolia University, Hohhot, Inner Mongolia, China Hepatoscience Section, Cell Lab Tech Inc, Sunnyvale, California, USA Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA PubMed articlesGoogle scholar articles
  • Hongbing Zhang State Key Laboratory of Medical Molecular Biology, Department of Physiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China PubMed articlesGoogle scholar articles
  • Pengyu Huang School of Life Science and Technology, ShanghaiTech University, Shanghai, China Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China PubMed articlesGoogle scholar articles
  • Wei Sun Biomanufacturing Center, Department of Mechanical Engineering, Tsinghua University, Beijing, China Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing, Tsinghua University, Beijing, China Overseas Expertise Introduction Center for Discipline Innovation, Tsinghua University, Beijing, China Department of Mechanical Engineering, Drexel University, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Yilei Mao Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC & Chinese Academy of Medical Sciences, Beijing, China PubMed articlesGoogle scholar articles
  1. Correspondence to Professor Yilei Mao, Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC & Chinese Academy of Medical Sciences, Beijing, China; pumch-liver{at}hotmail.com; Professor Wei Sun, Biomanufacturing Center, Department of Mechanical Engineering, Tsinghua University, Beijing, China; weisun{at}tsinghua.edu.cn; Professor Pengyu Huang, School of Life Science and Technology, ShanghaiTech University, Shanghai, China; huangpy{at}shanghaitech.edu.cn
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Citation

Yang H, Sun L, Pang Y, et al
Three-dimensional bioprinted hepatorganoids prolong survival of mice with liver failure
Gut 2021;70:567-574.

Publication history

  • Received September 28, 2019
  • Revised April 28, 2020
  • Accepted May 6, 2020
  • First published May 20, 2020.
Online issue publication 
May 24, 2021

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.