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Contributors SS, AS, NK-V and TK-T performed the experiments and analyses. SS and TB wrote the manuscript. SD assisted with the experimental design and the writing of the manuscript. TB conceived of and supervised the study, obtained funding, provided guidance with experimental design and writing of the manuscript. All authors critically revised the manuscript for important intellectual content.
Funding This study was funded by German Research Foundation (DFG BR4182/3-1). German Federal Ministry of Education and Research (BMBF 01 E0 1502).
Competing interests None declared.
Patient and public involvement Patients and/or the public were not involved in the design, conduct, reporting or dissemination plans of this research.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; externally peer reviewed.