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Risk factors in patients with COVID-19 developing severe liver injury during hospitalisation
  1. Ke Zhan1,
  2. Shengtao Liao1,
  3. Jinfang Li2,
  4. Yang Bai3,
  5. Lin Lv1,
  6. Keqi Yu1,
  7. Liewang Qiu1,4,
  8. Chuanfei Li1,
  9. Guodan Yuan5,
  10. An Zhang6,
  11. Zhechuan Mei1
  1. 1Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
  2. 2Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
  3. 3Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
  4. 4Department of Gastroenterology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China
  5. 5Department of Critical Care Medicine, Chongqing Public Health Medical Center, Chongqing, China
  6. 6Department of Critical Care Medicine, Chongqing Medical University Affiliated Second Hospital, Chongqing, China
  1. Correspondence to Professor Zhechuan Mei, Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China; meizhechuan{at}cqmu.edu.cn; Professor An Zhang, Department of Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China; zhangan{at}hospital.cqmu.edu.cn; Dr Guodan Yuan, Department of Critical Care Medicine, Chongqing Public Health Medical Center, Chongqing 400036, China; 71502294{at}qq.com

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We read with interest the work by Weber et al1 reporting that severe liver failure was observed in a patient during SARS-CoV-2 infection. They suggested that close monitoring of liver function is necessary, and further investigation is required to elucidate the risk factors for liver failure in patients with COVID-19. Previous studies have indicated that liver injury could affect the prognosis of patients with COVID-19, and mortality rate was significantly increased in patients with severe liver injury.2 3 However, the risk factors in patients with COVID-19 developing severe liver injury during hospitalisation have not been thoroughly investigated. Thus, in this study, patients with COVID-19 were recruited to identify the risk factors in patients with COVID-19 with severe liver injury.

A total of 192 patients diagnosed with COVID-19 were consecutively hospitalised at Chongqing Public Health Medical Center from January to March 2020, and 12 patients with existing liver disease had been excluded in this study. Liver injury was detected in 75 (39.06%) enrolled patients at admission and 133 (69.27%) during hospitalisation, respectively. Interestingly, liver injury …

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