Footnotes

• Contributors J-ML designed the study and wrote the protocol. J-ML prepared the statistical analyses and drafted the article, which was critically revised and approved by all authors. All authors had full access to the data and participated in the decision to submit for publication.

• Funding Supported by the Ministry of Science and Technology, Taiwan (grant number: TCTC 108-2321-B-002-040), the Ministry of Health and Welfare, Taiwan (MOHW108-CDC-C-114-112102), and the 'Center of Precision Medicine' of the Higher Education Sprout Project by the Ministry of Education (MOE), Taiwan (grant number: NTU-107L9014-1). The funding source had no role in study design, data collection, analysis, report writing or the decision to submit this paper for publication.

• Competing interests None declared.

• Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

• Patient consent for publication Not required.

• Provenance and peer review Not commissioned; internally peer reviewed.