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We agree with the comments1 2 on the recently reported randomised double-blind, placebo-controlled trial from our group on the efficacy of faecal microbiota transplantation (FMT) in patients with IBS3 that caution is required when using FMT to treat this condition. However, we have some further comments concerning the efficacy and safety of FMT in IBS.
The patients with IBS included in our randomised controlled trial (RCT)3 were only those with moderate symptom severity (IBS Symptom Severity Score (IBS-SSS) score between 175 and 300)2 and severe symptom severity (IBS-SSS score of ≥300).4 One way to evaluate the efficacy of FMT when using the IBS-SSS, as pointed out by Camilleri, is to look at the proportions of patients with moderate symptom severity and severe symptom severity at different time intervals after FMT.2 The raw results for our RCT from the IBS-SSS …