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Letter
Crohn’s disease instead of UC might increase the risk of small bowel cancer
  1. Rui Zhao1,
  2. Qian-Yi Wan1,
  3. Yutao Wu2,
  4. Yong Wang1,
  5. Ya-Ping Cui1,
  6. Xiaoding Shen1,
  7. Xiao Ting Wu1
  1. 1 Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Sichuan University West China Hospital, Chengdu, Sichuan, China
  2. 2 West China hospital of Stomatology, Sichuan University, Chengdu, China
  1. Correspondence to Professor Xiao Ting Wu, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Sichuan University West China Hospital, Chengdu 610041, China; wxt1{at}medmail.com.cn

https://doi.org/10.1136/gutjnl-2020-322201

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    We read with interest the study by Axelrad et al 1 which reported that Crohn’s disease (CD) and UC were associated with nearly ninefold and twofold increased risk of small bowel cancer (SBC), respectively. However, there were also two observational studies2 3 suggesting that UC was not associated with risk of SBC. Because epidemiological studies about IBD and risk of SBC were controversial, to better understand this issue, we conducted this meta-analysis.

    We searched the PubMed and Web of Science for relevant studies published before 1 June 2020. We included observational studies investigating the associations between IBD and risk of SBC (including adenocarcinoma, neuroendocrine tumour and sarcoma) and reporting the HR, OR or other measures of association. The pooled OR and 95% CIs were estimated with random-effect model when the significant …

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    Footnotes

    • Contributors RZ and Q-YW contributed equally in this study. RZ, Q-YW, YW, YW, Y-PC and XS collected and analysed the data. Q-YW and RZ wrote the manuscript under the guidance of XTW. All the authors have read manuscript, and XTW approved the final manuscript.

    • Funding This work was supported by Sichuan Province Science and Technology Support Project (2018SZ0189).

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Provenance and peer review Not commissioned; externally peer reviewed.