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Hepatology
Original research
Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites

Authors

  • Xiang Zhang State Key Laboratory of Digestive Disease, Institute of Digestive Disease and The Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China PubMed articlesGoogle scholar articles
  • Olabisi Oluwabukola Coker State Key Laboratory of Digestive Disease, Institute of Digestive Disease and The Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China PubMed articlesGoogle scholar articles
  • Eagle SH Chu State Key Laboratory of Digestive Disease, Institute of Digestive Disease and The Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China PubMed articlesGoogle scholar articles
  • Kaili Fu State Key Laboratory of Digestive Disease, Institute of Digestive Disease and The Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China PubMed articlesGoogle scholar articles
  • Harry C H Lau State Key Laboratory of Digestive Disease, Institute of Digestive Disease and The Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China PubMed articlesGoogle scholar articles
  • Yi-Xiang Wang Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong SAR, China PubMed articlesGoogle scholar articles
  • Anthony W H Chan Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China PubMed articlesGoogle scholar articles
  • Hong Wei Department of Precision Medicine, Sun Yat-Sen University First Affiliated Hospital, Guangzhou, Guangdong, China Department of Laboratory Animal Science, College of Basic Medical Sciences, Third Military Medical University, Chongqing, China PubMed articlesGoogle scholar articles
  • Xiaoyong Yang Department of Comparative Medicine and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA PubMed articlesGoogle scholar articles
  • Joseph J Y Sung State Key Laboratory of Digestive Disease, Institute of Digestive Disease and The Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China PubMed articlesGoogle scholar articles
  • Jun Yu State Key Laboratory of Digestive Disease, Institute of Digestive Disease and The Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China PubMed articlesGoogle scholar articles
  1. Correspondence to Jun Yu, Institute of Digestive Disease and The Department of Medicine and Therapeutics, Chinese University of Hong Kong, New Territories, Hong Kong; junyu{at}cuhk.edu.hk
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Citation

Zhang X, Coker OO, Chu ES, et al
Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites
Gut 2021;70:761-774.

Publication history

  • Received August 19, 2019
  • Revised June 4, 2020
  • Accepted June 15, 2020
  • First published July 21, 2020.
Online issue publication 
March 12, 2022

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.