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Thiopurine monotherapy has a limited place in treatment of patients with mild-to-moderate Crohn’s disease

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  • Presented at These data have been presented as an oral presentation at the 13th European Crohn’s and Colitis Organization congress 2018 (Vienna, Austria) and the 30th Belgian Week of Gastroenterology (Antwerp, Belgium).

  • Contributors BV contributed to study design, data acquisition and interpretation, statistical analysis and drafting of the manuscript. LB contributed to data acquisition. JS contributed to critical revision of the manuscript. SV and MF contributed to study design, data interpretation, supervision and critical revision of the manuscript. All authors agreed with the final version of the manuscript prior to submission.

  • Funding SV and MF are senior clinical investigators of the research foundation Flanders (FWO), Belgium.

  • Competing interests BV reports financial support for research from Pfizer; lecture fees from Abbvie, Ferring, Takeda Pharmaceuticals, Janssen and R Biopharm; consultancy fees from Janssen and Sandoz. JS reports lecture fees from Abbvie, Takeda, Janssen and Nestle Health Sciences. SV reports financial support for research: MSD, AbbVie, Takeda, Pfizer, J&J; Lecture fee(s): MSD, AbbVie, Takeda, Ferring, Centocor, Hospira, Pfizer, J&J, Genentech/Roche; Consultancy: MSD, AbbVie, Takeda, Ferring, Centocor, Hospira, Pfizer, J&J, Genentech/Roche, Celgene, Mundipharma, Celltrion, SecondGenome, Prometheus, Shire, Prodigest, Gilead, Galapagos. MF reports financial support for research: Amgen, Biogen, Janssen, Pfizer, Takeda, Consultancy: Abbvie, Boehringer-Ingelheim, MSD, Pfizer, Sandoz, Takeda and Thermo Fisher; Speakers fee: Abbvie, Amgen, Biogen, Boehringer-Ingelheim, Falk, Ferring, Janssen, Lamepro, MSD, Mylan, Pfizer, Sandoz, and Takeda.

  • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

  • Patient consent for publication Not required.

  • Ethics approval All patients included in the analysis had given written consent to participate in the Institutional Review Board approved IBD Biobank (B322201213950/S53684).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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