Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic KLF4 mutations predominantly in low-grade regions

Kohei Fujikura; Waki Hosoda; Matthäus Felsenstein; Qianqian Song; Johannes G Reiter; Lily Zheng; Violeta Beleva Guthrie; Natalia Rincon; Marco Dal Molin; Jonathan Dudley; Joshua D Cohen; Pei Wang; Catherine G Fischer; Alicia M Braxton; Michaël Noë; Martine Jongepier; Carlos Fernández-del Castillo; Mari Mino-Kenudson; C Max Schmidt; Michele T Yip-Schneider; Rita T Lawlor; Roberto Salvia; Nicholas J Roberts; Elizabeth D Thompson; Rachel Karchin; Anne Marie Lennon; Yuchen Jiao; Laura D Wood

doi:10.1136/gutjnl-2020-321217

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Pancreas

Original research

Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic KLF4 mutations predominantly in low-grade regions

Authors

Kohei Fujikura Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Waki Hosoda Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan PubMed articles Google scholar articles
Matthäus Felsenstein Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of Surgery, Charité Universitätsmedizin, Berlin, Germany PubMed articles Google scholar articles
Qianqian Song State Key Lab of Molecular Oncology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China PubMed articles Google scholar articles
Johannes G Reiter Canary Center for Cancer Early Detection in Department of Radiology, Stanford Cancer Institute, and Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, California, USA PubMed articles Google scholar articles
Lily Zheng McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Violeta Beleva Guthrie Personal Genome Diagnostics, Baltimore, Maryland, USA PubMed articles Google scholar articles
Natalia Rincon Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA PubMed articles Google scholar articles
Marco Dal Molin Ludwig Center for Cancer Genetics and Therapeutics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Jonathan Dudley Ludwig Center for Cancer Genetics and Therapeutics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Joshua D Cohen Ludwig Center for Cancer Genetics and Therapeutics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Pei Wang State Key Lab of Molecular Oncology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China PubMed articles Google scholar articles
Catherine G Fischer Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Alicia M Braxton Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Michaël Noë Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Martine Jongepier Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Carlos Fernández-del Castillo Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articles Google scholar articles
Mari Mino-Kenudson Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articles Google scholar articles
C Max Schmidt Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA PubMed articles Google scholar articles
Michele T Yip-Schneider Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA PubMed articles Google scholar articles
Rita T Lawlor ARC-NET: Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy PubMed articles Google scholar articles
Roberto Salvia General and Pancreatic Surgery Department, The Pancreas Institute and Hospital Trust of Verona, Verona, Italy PubMed articles Google scholar articles
Nicholas J Roberts Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Elizabeth D Thompson Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Rachel Karchin Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA PubMed articles Google scholar articles
Anne Marie Lennon Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Yuchen Jiao State Key Lab of Molecular Oncology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China PubMed articles Google scholar articles
Laura D Wood Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles

Correspondence to Dr Laura D Wood, Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; ldwood{at}jhmi.edu; Dr Yuchen Jiao, State Key Lab of Molecular Oncology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; jiaoyuchen{at}cicams.ac.cn

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Citation

Fujikura K, Hosoda W, Felsenstein M, et al

Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic KLF4 mutations predominantly in low-grade regions

Gut 2021;70:928-939.

Publication history

Received March 25, 2020
Revised August 6, 2020
Accepted August 9, 2020
First published October 7, 2020.

Online issue publication

January 08, 2022

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