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Hepatology
Original research
Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis

Authors

  • Eun Hee Koh Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea PubMed articlesGoogle scholar articles
  • Ji Eun Yoon Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea PubMed articlesGoogle scholar articles
  • Myoung Seok Ko Biomedical Research Center, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea PubMed articlesGoogle scholar articles
  • Jaechan Leem Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea PubMed articlesGoogle scholar articles
  • Ji-Young Yun Biomedical Research Center, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea PubMed articlesGoogle scholar articles
  • Chung Hwan Hong Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea PubMed articlesGoogle scholar articles
  • Yun Kyung Cho Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea PubMed articlesGoogle scholar articles
  • Seung Eun Lee Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea PubMed articlesGoogle scholar articles
  • Jung Eun Jang Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea PubMed articlesGoogle scholar articles
  • Ji Yeon Baek Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea PubMed articlesGoogle scholar articles
  • Hyun Ju Yoo The Convergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea PubMed articlesGoogle scholar articles
  • Su Jung Kim The Convergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea PubMed articlesGoogle scholar articles
  • Chang Ohk Sung Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea PubMed articlesGoogle scholar articles
  • Joon Seo Lim Clinical Research Center, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea PubMed articlesGoogle scholar articles
  • Won-Il Jeong Laboratory of Liver Research, Graduate School of Medical Science and Engineering, KAIST, Daejeon, South Korea PubMed articlesGoogle scholar articles
  • Sung Hoon Back School of Biological Sciences, University of Ulsan, Ulsan, South Korea PubMed articlesGoogle scholar articles
  • In-Jeoung Baek The Convergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea PubMed articlesGoogle scholar articles
  • Sandra Torres Department of Cell Death and Proliferation, Instituto Investigaciones Biomédicas de Barcelona (IIBB), CSIC, Barcelona, Spain and Liver Unit-IDIBAPS and Centro de Investigación Biomédica en Red (CIBERehd), Barcelona, Spain PubMed articlesGoogle scholar articles
  • Estel Solsona-Vilarrasa Department of Cell Death and Proliferation, Instituto Investigaciones Biomédicas de Barcelona (IIBB), CSIC, Barcelona, Spain and Liver Unit-IDIBAPS and Centro de Investigación Biomédica en Red (CIBERehd), Barcelona, Spain PubMed articlesGoogle scholar articles
  • Laura Conde de la Rosa Department of Cell Death and Proliferation, Instituto Investigaciones Biomédicas de Barcelona (IIBB), CSIC, Barcelona, Spain and Liver Unit-IDIBAPS and Centro de Investigación Biomédica en Red (CIBERehd), Barcelona, Spain PubMed articlesGoogle scholar articles
  • Carmen Garcia-Ruiz Department of Cell Death and Proliferation, Instituto Investigaciones Biomédicas de Barcelona (IIBB), CSIC, Barcelona, Spain and Liver Unit-IDIBAPS and Centro de Investigación Biomédica en Red (CIBERehd), Barcelona, Spain University of Southern California Research Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA PubMed articlesGoogle scholar articles
  • Ariel E Feldstein Department of Pediatrics, University of California San Diego, La Jolla, CA, USA PubMed articlesGoogle scholar articles
  • Jose C Fernandez-Checa Department of Cell Death and Proliferation, Instituto Investigaciones Biomédicas de Barcelona (IIBB), CSIC, Barcelona, Spain and Liver Unit-IDIBAPS and Centro de Investigación Biomédica en Red (CIBERehd), Barcelona, Spain University of Southern California Research Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA PubMed articlesGoogle scholar articles
  • Ki-Up Lee Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea PubMed articlesGoogle scholar articles
  1. Correspondence to Professor Ki-Up Lee, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea; kulee{at}amc.seoul.kr; Professor Jose C Fernandez-Checa, Department of Cell Death and Proliferation, Instituto Investigaciones Biomédicas de Barcelona (IIBB), CSIC, Barcelona, Spain; checa229{at}yahoo.com
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Citation

Koh EH, Yoon JE, Ko MS, et al
Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis
Gut 2021;70:1954-1964.

Publication history

  • Received July 10, 2020
  • Revised October 26, 2020
  • Accepted October 26, 2020
  • First published November 18, 2020.
Online issue publication 
January 10, 2022

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.