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Original research
Evaluating the utility of tumour mutational signatures for identifying hereditary colorectal cancer and polyposis syndrome carriers

Authors

  • Peter Georgeson Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia PubMed articlesGoogle scholar articles
  • Bernard J Pope Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia Melbourne Bioinformatics, The University of Melbourne, Melbourne, Victoria, Australia PubMed articlesGoogle scholar articles
  • Christophe Rosty Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia Envoi Pathology, Brisbane, Queensland, Australia University of Queensland, School of Medicine, Herston, Queensland, Australia PubMed articlesGoogle scholar articles
  • Mark Clendenning Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia PubMed articlesGoogle scholar articles
  • Khalid Mahmood Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia Melbourne Bioinformatics, The University of Melbourne, Melbourne, Victoria, Australia PubMed articlesGoogle scholar articles
  • Jihoon E Joo Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia PubMed articlesGoogle scholar articles
  • Romy Walker Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia PubMed articlesGoogle scholar articles
  • Ryan A Hutchinson Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia PubMed articlesGoogle scholar articles
  • Susan Preston Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia PubMed articlesGoogle scholar articles
  • Julia Como Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia PubMed articlesGoogle scholar articles
  • Sharelle Joseland Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia PubMed articlesGoogle scholar articles
  • Aung Ko Win Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Victoria, Australia Genetic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, Melbourne, Victoria, Australia PubMed articlesGoogle scholar articles
  • Finlay A Macrae Genetic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, Melbourne, Victoria, Australia Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Melbourne, Victoria, Australia PubMed articlesGoogle scholar articles
  • John L Hopper Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Victoria, Australia PubMed articlesGoogle scholar articles
  • Dmitri Mouradov Personalised Oncology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia PubMed articlesGoogle scholar articles
  • Peter Gibbs Personalised Oncology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia Department of Medical Oncology, Western Health, Victoria, Australia PubMed articlesGoogle scholar articles
  • Oliver M Sieber Personalised Oncology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia PubMed articlesGoogle scholar articles
  • Dylan E O'Sullivan Department of Oncology, University of Calgary, Calgary, Alberta, Canada Department of Community Health Sciences, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada PubMed articlesGoogle scholar articles
  • Darren R Brenner Department of Oncology, University of Calgary, Calgary, Alberta, Canada Department of Community Health Sciences, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, Alberta, Canada PubMed articlesGoogle scholar articles
  • Steve Gallinger Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, The University of Toronto, Toronto, Ontario, Canada Ontario Institute for Cancer Research, Toronto, Ontario, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Mark A Jenkins University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Victoria, Australia PubMed articlesGoogle scholar articles
  • Ingrid M Winship Genetic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, Melbourne, Victoria, Australia Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia PubMed articlesGoogle scholar articles
  • Daniel D Buchanan Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia Genetic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, Melbourne, Victoria, Australia PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Daniel D Buchanan, Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia; daniel.buchanan{at}unimelb.edu.au
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Citation

Georgeson P, Pope BJ, Rosty C, et al
Evaluating the utility of tumour mutational signatures for identifying hereditary colorectal cancer and polyposis syndrome carriers
Gut 2021;70:2138-2149.

Publication history

  • Received December 12, 2019
  • Revised December 8, 2020
  • Accepted December 12, 2020
  • First published January 7, 2021.
Online issue publication 
May 02, 2022

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© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.