Activated intestinal muscle cells promote preadipocyte migration: a novel mechanism for creeping fat formation in Crohn’s disease

Ren Mao; Genevieve Doyon; Ilyssa O Gordon; Jiannan Li; Sinan Lin; Jie Wang; Thi Hong Nga Le; Michael Elias; Satya Kurada; Brian Southern; Mitchell Olman; Minhu Chen; Shuai Zhao; Dina Dejanovic; Jyotsna Chandra; Pranab K Mukherjee; Gail West; David R Van Wagoner; Claudio Fiocchi; Florian Rieder

doi:10.1136/gutjnl-2020-323719

Article info

Inflammatory bowel disease

Original research

Activated intestinal muscle cells promote preadipocyte migration: a novel mechanism for creeping fat formation in Crohn’s disease

Authors

Ren Mao Department of Gastroenterology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China PubMed articles Google scholar articles
Genevieve Doyon Aging Institute, University of Pittsburgh, Pittsburgh, PA, USADepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA PubMed articles Google scholar articles
Ilyssa O Gordon Department of Pathology, Robert J Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic Foundation, Cleveland, OH, USA PubMed articles Google scholar articles
Jiannan Li Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA PubMed articles Google scholar articles
Sinan Lin Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA PubMed articles Google scholar articles
Jie Wang Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA PubMed articles Google scholar articles
Thi Hong Nga Le Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA PubMed articles Google scholar articles
Michael Elias Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA PubMed articles Google scholar articles
Satya Kurada Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA PubMed articles Google scholar articles
Brian Southern Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA PubMed articles Google scholar articles
Mitchell Olman Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA PubMed articles Google scholar articles
Minhu Chen Department of Gastroenterology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China PubMed articles Google scholar articles
Shuai Zhao Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA PubMed articles Google scholar articles
Dina Dejanovic Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA PubMed articles Google scholar articles
Jyotsna Chandra Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA PubMed articles Google scholar articles
Pranab K Mukherjee Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA PubMed articles Google scholar articles
Gail West Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA PubMed articles Google scholar articles
David R Van Wagoner Department of Cardiovascular and Metabolic Science, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA PubMed articles Google scholar articles
Claudio Fiocchi Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USADepartment of Gastroenterology, Hepatology and Nutrition, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA PubMed articles Google scholar articles
Florian Rieder Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USADepartment of Gastroenterology, Hepatology and Nutrition, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA PubMed articles Google scholar articles

Correspondence to Dr Florian Rieder, Inflammation and Immunity NC22, Cleveland Clinic Foundation, Cleveland, Ohio, USA; riederf{at}ccf.org

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Citation

Mao R, Doyon G, Gordon IO, et al

Activated intestinal muscle cells promote preadipocyte migration: a novel mechanism for creeping fat formation in Crohn’s disease

Gut Published Online First: 19 January 2021. doi: 10.1136/gutjnl-2020-323719

Publication history

Received November 28, 2020
Revised December 22, 2020
Accepted January 7, 2021
First published January 19, 2021.

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