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Original research
Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways

Authors

  • María Arnoriaga-Rodríguez Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University Hospital, Girona, SpainNutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IdibGi), Girona, SpainCIBER Pathophysiology of Obesity and Nutrition (CIBEROBN), Madrid, SpainDeparment of Medical Sciences, Faculty of Medicine, University of Girona, Girona, Spain PubMed articlesGoogle scholar articles
  • Jordi Mayneris-Perxachs Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University Hospital, Girona, SpainNutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IdibGi), Girona, SpainCIBER Pathophysiology of Obesity and Nutrition (CIBEROBN), Madrid, Spain PubMed articlesGoogle scholar articles
  • Oren Contreras-Rodríguez Nutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IdibGi), Girona, SpainDepartment of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL) and CIBERSAM, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Aurelijus Burokas Laboratory of Neuropharmacology, Deparment of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, SpainPresent address: Institute of Biochemistry, Life Sciences Center, Vilnius University, Saulėtekio av. 7, LT-10257 Vilnius, Lithuania PubMed articlesGoogle scholar articles
  • Juan-Antonio Ortega-Sanchez Laboratory of Neuropharmacology, Deparment of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Gerard Blasco Institute of Diagnostic Imaging (IDI)-Research Unit (IDIR), Parc Sanitari Pere Virgili, Barcelona, SpainMedical Imaging, Girona Biomedical Research Institute (IdibGi), Girona, Spain PubMed articlesGoogle scholar articles
  • Claudia Coll Neuroimmunology and Multiple Sclerosis Unit, Deparment of Neurology, Dr. Josep Trueta University Hospital, Girona, Spain PubMed articlesGoogle scholar articles
  • Carles Biarnés Medical Imaging, Girona Biomedical Research Institute (IdibGi), Girona, Spain PubMed articlesGoogle scholar articles
  • Anna Castells-Nobau Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University Hospital, Girona, SpainNutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IdibGi), Girona, SpainCIBER Pathophysiology of Obesity and Nutrition (CIBEROBN), Madrid, Spain PubMed articlesGoogle scholar articles
  • Josep Puig Deparment of Medical Sciences, Faculty of Medicine, University of Girona, Girona, SpainInstitute of Diagnostic Imaging (IDI)-Research Unit (IDIR), Parc Sanitari Pere Virgili, Barcelona, SpainMedical Imaging, Girona Biomedical Research Institute (IdibGi), Girona, Spain PubMed articlesGoogle scholar articles
  • Josep Garre-Olmo Deparment of Medical Sciences, Faculty of Medicine, University of Girona, Girona, SpainResearch Group on Aging, Health and Disability, Girona Biomedical Research Institute, Health Assistance Institute, Girona, Spain PubMed articlesGoogle scholar articles
  • Rafel Ramos Deparment of Medical Sciences, Faculty of Medicine, University of Girona, Girona, SpainInstitut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, Catalonia, Spain PubMed articlesGoogle scholar articles
  • Salvador Pedraza Deparment of Medical Sciences, Faculty of Medicine, University of Girona, Girona, SpainMedical Imaging, Girona Biomedical Research Institute (IdibGi), Girona, SpainDeparment of Radiology, Dr. Josep Trueta University Hospital, Girona, Spain PubMed articlesGoogle scholar articles
  • Ramon Brugada Deparment of Medical Sciences, Faculty of Medicine, University of Girona, Girona, SpainCardiovascular Genetics Center, CIBER-CV, Girona Biomedical Research Institute (IDIBGI), Dr. Josep Trueta University Hospital, Girona, SpainBiomedical Research Networking Center on Cardiovascular Diseases (CIBERCV), Madrid, SpainDeparment of Cardiology, Dr. Josep Trueta University Hospital, Girona, Spain PubMed articlesGoogle scholar articles
  • Joan C Vilanova Deparment of Medical Sciences, Faculty of Medicine, University of Girona, Girona, SpainMedical Imaging, Girona Biomedical Research Institute (IdibGi), Girona, SpainDeparment of Radiology, Dr. Josep Trueta University Hospital, Girona, Spain PubMed articlesGoogle scholar articles
  • Joaquín Serena Deparment of Medical Sciences, Faculty of Medicine, University of Girona, Girona, SpainDepartment of Neurology, Dr. Josep Trueta University Hospital, Girona Biomedical Research Institute (IDIBGI), Girona, Spain PubMed articlesGoogle scholar articles
  • Jordi Barretina Girona Biomedical Research Institute (IdibGi), Dr. Josep Trueta University Hospital, Girona, Spain PubMed articlesGoogle scholar articles
  • Jordi Gich Deparment of Medical Sciences, Faculty of Medicine, University of Girona, Girona, SpainNeurodegeneration and Neuroinflammation Group, Girona Biomedical Research Institute (IdibGi), Girona, Spain PubMed articlesGoogle scholar articles
  • Vicente Pérez-Brocal Joint Investigation Unit of FISABIO and I2Sysbio, University of València and CSIC, Valencia, SpainBiomedical Research Networking Center for Epidemiology and Public Health (CIBERESP), Madrid, Spain PubMed articlesGoogle scholar articles
  • Andrés Moya Joint Investigation Unit of FISABIO and I2Sysbio, University of València and CSIC, Valencia, SpainBiomedical Research Networking Center for Epidemiology and Public Health (CIBERESP), Madrid, Spain PubMed articlesGoogle scholar articles
  • Xavier Fernández-Real Institute of Mathematics, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland PubMed articlesGoogle scholar articles
  • Lluis Ramio-Torrentà Deparment of Medical Sciences, Faculty of Medicine, University of Girona, Girona, SpainNeuroimmunology and Multiple Sclerosis Unit, Deparment of Neurology, Dr. Josep Trueta University Hospital, Girona, SpainDepartment of Neurology, Dr. Josep Trueta University Hospital, Girona Biomedical Research Institute (IDIBGI), Girona, SpainNeurodegeneration and Neuroinflammation Group, Girona Biomedical Research Institute (IdibGi), Girona, SpainRed Española de Esclerosis Múltiple (REEM), Madrid, Spain PubMed articlesGoogle scholar articles
  • Reinald Pamplona Metabolic Physiopathology Research Group, Experimental Medicine Department, Lleida University-Lleida Biochemical Research Institute (UdL-IRBLleida), Lleida, Spain PubMed articlesGoogle scholar articles
  • Joaquim Sol Metabolic Physiopathology Research Group, Experimental Medicine Department, Lleida University-Lleida Biochemical Research Institute (UdL-IRBLleida), Lleida, SpainInstitut Català de la Salut, Atenció Primària, Lleida, SpainResearch Support Unit Lleida, Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Lleida, Spain PubMed articlesGoogle scholar articles
  • Mariona Jové Metabolic Physiopathology Research Group, Experimental Medicine Department, Lleida University-Lleida Biochemical Research Institute (UdL-IRBLleida), Lleida, Spain PubMed articlesGoogle scholar articles
  • Wifredo Ricart Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University Hospital, Girona, SpainNutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IdibGi), Girona, SpainCIBER Pathophysiology of Obesity and Nutrition (CIBEROBN), Madrid, SpainDeparment of Medical Sciences, Faculty of Medicine, University of Girona, Girona, Spain PubMed articlesGoogle scholar articles
  • Manuel Portero-Otin Metabolic Physiopathology Research Group, Experimental Medicine Department, Lleida University-Lleida Biochemical Research Institute (UdL-IRBLleida), Lleida, Spain PubMed articlesGoogle scholar articles
  • Rafael Maldonado Laboratory of Neuropharmacology, Deparment of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, SpainHospital del Mar Medical Research Institute (IMIM), Barcelona, Spain PubMed articlesGoogle scholar articles
  • Jose Manuel Fernández-Real Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University Hospital, Girona, SpainNutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IdibGi), Girona, SpainCIBER Pathophysiology of Obesity and Nutrition (CIBEROBN), Madrid, SpainDeparment of Medical Sciences, Faculty of Medicine, University of Girona, Girona, Spain PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Jordi Mayneris-Perxachs, Institute of Biomedical Research of Girona Dr Josep Trueta, Girona, Spain; jmayneris{at}idibgi.org; Dr Rafael Maldonado, Pompeu Fabra University, Barcelona, Spain; rafael.maldonado{at}upf.edu; Dr Jose Manuel Fernández-Real, Institute of Biomedical Research of Girona Dr Josep Trueta, Girona 17190, Spain; jmfreal{at}idibgi.org
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Citation

Arnoriaga-Rodríguez M, Mayneris-Perxachs J, Contreras-Rodríguez O, et al
Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways

Publication history

  • Received October 14, 2020
  • Revised December 16, 2020
  • Accepted January 8, 2021
  • First published January 29, 2021.

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