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We read with interest the recent article by Cash et al comparing colon capsule (CCE) and CT colonography (CTC) with optical colonoscopy (OC) for detecting colonic polyps and colorectal cancer (CRC) in a screening population.1 The study reports low CTC detection rates for ≥6 mm and ≥10 mm polyps of only 8.6% and 6.3%, respectively. These were much lower than the detection rates seen for CCE and OC. These results contradict larger trials, where the performance of CTC and OC tests are similar. The Dutch COCOS randomised controlled trial (RCT) in a screening population ultimately reported identical advanced neoplasia detection rates for CTC and OC.2 3 The UK SIGGAR RCT reported identical detection rates of 11% for large polyps or CRC.4 Earlier studies from the USA also support the use of CTC.5 6 The 8.6% …
Contributors NEB, AP, RS, BR and DJMT conceived and drafted the letter. All authors commented on drafts of the letter. All authors have approved the final draft of the manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting or dissemination plans of this research.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; externally peer reviewed.
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