Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment

Zhibo Xie; Ya Gao; Chiakang Ho; Lequn Li; Chen Jin; Xiaoyi Wang; Caifeng Zou; Yishen Mao; Xiaobo Wang; Qingfeng Li; Deliang Fu; Yi-Fan Zhang

doi:10.1136/gutjnl-2020-323014

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Pancreas

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Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment

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Zhibo Xie Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Children's Hospital, Shanghai, China Department of Pancreatic Surgery, Huashan Hospital Fudan University, Shanghai, Shanghai, China PubMed articles Google scholar articles
Ya Gao Department of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai, China PubMed articles Google scholar articles
Chiakang Ho Department of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai, China PubMed articles Google scholar articles
Lequn Li Department of Hepatobiliary and Pancreas Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Guangxi, China PubMed articles Google scholar articles
Chen Jin Department of Pancreatic Surgery, Huashan Hospital Fudan University, Shanghai, Shanghai, China PubMed articles Google scholar articles
Xiaoyi Wang Department of Pancreatic Surgery, Huashan Hospital Fudan University, Shanghai, Shanghai, China PubMed articles Google scholar articles
Caifeng Zou Department of Pancreatic Surgery, Huashan Hospital Fudan University, Shanghai, Shanghai, China PubMed articles Google scholar articles
Yishen Mao Department of Pancreatic Surgery, Huashan Hospital Fudan University, Shanghai, Shanghai, China PubMed articles Google scholar articles
Xiaobo Wang Department of Hepatobiliary and Pancreas Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Guangxi, China PubMed articles Google scholar articles
Qingfeng Li Department of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai, China PubMed articles Google scholar articles
Deliang Fu Department of Pancreatic Surgery, Huashan Hospital Fudan University, Shanghai, Shanghai, China PubMed articles Google scholar articles
Yi-Fan Zhang Department of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai, China PubMed articles Google scholar articles

Correspondence to Dr Yi-Fan Zhang, Department of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China; zhangyifan82{at}126.com; Professor Deliang Fu; lunwenfudan{at}163.com; Professor Qingfeng Li; dr.liqingfeng{at}shsmu.edu.cn

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Citation

Xie Z, Gao Y, Ho C, et al

Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment

Gut 2022;71:568-579.

Publication history

Received September 7, 2020
Revised March 23, 2021
Accepted March 24, 2021
First published April 7, 2021.

Online issue publication

May 11, 2022

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