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Original research
Ginseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy

Authors

  • Jumin Huang Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Di Liu Computational Virology Group, Center for Bacteria and Virus Resources and Application, Wuhan Institute of Virology Chinese Academy of Sciences, Wuhan, Hubei, China PubMed articlesGoogle scholar articles
  • Yuwei Wang Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Liang Liu Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Jian Li Precision Medicine Institute, Sun Yat-sen University First Affiliated Hospital, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Jing Yuan Department of Bacteriology, Capital Institute of Pediatrics, Chaoyang District, Beijing, China PubMed articlesGoogle scholar articles
  • Zhihong Jiang Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Zebo Jiang Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • WL Wendy Hsiao Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Haizhou Liu Computational Virology Group, Center for Bacteria and Virus Resources and Application, Wuhan Institute of Virology Chinese Academy of Sciences, Wuhan, Hubei, China PubMed articlesGoogle scholar articles
  • Imran Khan Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Ying Xie Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Jianlin Wu Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Yajia Xie Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Yizhong Zhang Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Yu Fu Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Junyi Liao Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Wenjun Wang Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Huanling Lai Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Axi Shi Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Jun Cai Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Lianxiang Luo The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, Guangdong, China PubMed articlesGoogle scholar articles
  • Runze Li Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Xiaojun Yao Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Xingxing Fan Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Qibiao Wu Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Zhongqiu Liu Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Peiyu Yan Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Jingguang Lu Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Mingrong Yang Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Lin Wang Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  • Yabing Cao Department of Oncology, Kiang Wu Hospital, Macau, Macau, China PubMed articlesGoogle scholar articles
  • Hong Wei Precision Medicine Institute, Sun Yat-sen University First Affiliated Hospital, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Elaine Lai-Han Leung Dr Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Elaine Lai-Han Leung, Macau University of Science and Technology State Key Laboratory of Quality Research in Chinese Medicines, Taipa, Macau 123, China; lhleung{at}must.edu.mo; Professor Hong Wei; weihong63528{at}163.com; Dr Yabing Cao; sumscaoyabing{at}hotmail.com
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Citation

Huang J, Liu D, Wang Y, et al
Ginseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy

Publication history

  • Received March 5, 2020
  • Revised April 5, 2021
  • Accepted May 4, 2021
  • First published May 18, 2021.

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