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Liver injury, hypoalbuminaemia and severe SARS-CoV-2 infection
  1. Clare Elizabeth Foley1,
  2. Christopher Mulvey2,
  3. Maria Boylan3,
  4. Niamh Reidy4,
  5. Paul Reidy4,
  6. David Moynan4,
  7. Amy Worrall4,
  8. Ger Curley2,3,
  9. Karen Boland2,5,
  10. Eoghan de Barra2,4,
  11. John D Ryan1,2
  1. 1Department of Hepatology, Beaumont Hospital, Dublin, Ireland
  2. 2Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland
  3. 3Department of Anaesthesia, Beaumont Hospital, Dublin, Ireland
  4. 4Department of Infectious Diseases, Beaumont Hospital, Dublin, Ireland
  5. 5Department of Gastroenterology, Beaumont Hospital, Dublin, Ireland
  1. Correspondence to Dr Clare Elizabeth Foley, Department of Hepatology, Beaumont Hospital, Dublin 9, Ireland; foleyclare123{at}gmail.com

https://doi.org/10.1136/gutjnl-2021-324570

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    We have read with interest the recent study published in Gut by Weber et al1 outlining liver abnormalities in 217 patients admitted with COVID-19 infection in Germany. Along with respiratory failure, deranged liver blood tests have been demonstrated in many cohort studies of patients admitted with SARS-CoV-2 infection, the clinical relevance of which has been unclear to date.2 3

    The authors of this study demonstrated that deranged liver blood tests on admission were associated with more severe morbidity and mortality. Notably, hypoalbuminaemia on admission in this cohort was associated with a severe COVID-19 disease course.

    A review of 310 patients admitted with COVID-19 to our institution in Dublin revealed abnormal liver blood tests …

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    Footnotes

    • Contributors CEF collected and analysed the data. CM and KB carried out the statistics on the data. MB, NR, PR and AW collected the data. GC, EdB and JR supervised the project.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

    • Provenance and peer review Not commissioned; externally peer reviewed.