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We read with interest the study of Bojarski et al conducted in non-coeliac disease patients suffering from all subtypes of irritable bowel syndrome (IBS) according to Rome 3 criteria. The investigators showed symptom improvement in 57% of patients with IBS following a gluten-free diet (GFD) over 2 months. Interestingly, improvement of symptoms as well as stool pattern was noted in all IBS subtypes.1 Further, the authors report poor specificity and sensitivity for endoscope-based confocal laser endomicroscopy (eCLE) for detecting wheat sensitivity, defined by the authors as symptomatic improvement on a GFD.1 Based on these observations, the authors advocate an 8-week trial of GFD in patients with IBS, irrespective of …
Contributors JT and LMB contributed equally to drafting and revision of the manuscript.
Funding Supported by a Methusalem grant from KU Leuven to JT.
Competing interests None declared.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.
Provenance and peer review Not commissioned; internally peer reviewed.
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