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Letter to the editor: prospective, double-blind diagnostic multicentre study of confocal laser endomicroscopy for wheat sensitivity in patients with irritable bowel syndrome
  1. Lukas Michaja Balsiger1,
  2. Jan Tack1,2
  1. 1Translational Research in Gastrointestinal Disorders, KU Leuven, Leuven, Belgium
  2. 2Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium
  1. Correspondence to Prof. Jan Tack, Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium; jan.tack{at}

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We read with interest the study of Bojarski et al conducted in non-coeliac disease patients suffering from all subtypes of irritable bowel syndrome (IBS) according to Rome 3 criteria. The investigators showed symptom improvement in 57% of patients with IBS following a gluten-free diet (GFD) over 2 months. Interestingly, improvement of symptoms as well as stool pattern was noted in all IBS subtypes.1 Further, the authors report poor specificity and sensitivity for endoscope-based confocal laser endomicroscopy (eCLE) for detecting wheat sensitivity, defined by the authors as symptomatic improvement on a GFD.1 Based on these observations, the authors advocate an 8-week trial of GFD in patients with IBS, irrespective of …

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  • Contributors JT and LMB contributed equally to drafting and revision of the manuscript.

  • Funding Supported by a Methusalem grant from KU Leuven to JT.

  • Competing interests None declared.

  • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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