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Genetically proxied ketohexokinase function and risk of colorectal cancer: a Mendelian randomisation study

https://doi.org/10.1136/gutjnl-2021-326299

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    Footnotes

    • Contributors AMB and MCGJB: conception or design of the work. CGS, JLJMS, CJHK, SJPME, PCD, MMJG, AW, CDAS, PL and RH: acquisition. GAMB, PL, PIHGS, RH and MW: analysis. AMB, MCGJB, CGS, JLJMS, CJHK, SJPME, PCD, MMJG, AW, CDAS, GAMB, PL, PIHGS, RH and MW: interpretation of data. AMB, MCGJB, CGS, JLJMS, CJHK, SJPME, PCD, MMJG, AW, CDAS, GAMB, PL, PIHGS, RH, MW: draft and/or revision of the manuscript.

    • Funding This study was supported by the Dutch Diabetes Research Foundation (personal grant #2017.82.004 to MCGJB). The Maastricht Study was supported by the European Regional Development Fund via OP-Zuid, the Province of Limburg, the Dutch Ministry of Economic Affairs (grant 31O.041), Stichting De Weijerhorst (Maastricht, the Netherlands), the Pearl String Initiative Diabetes (Amsterdam, the Netherlands), School for Cardiovascular Diseases (CARIM, Maastricht, the Netherlands), School for Public Health and Primary Care (CAPHRI, Maastricht, the Netherlands), School for Nutrition and Translational Research in Metabolism (NUTRIM, Maastricht, the Netherlands), Stichting Annadal (Maastricht, the Netherlands), Health Foundation Limburg (Maastricht, the Netherlands), and by unrestricted grants from Janssen-Cilag B.V. (Tilburg, the Netherlands), Novo Nordisk Farma B.V. (Alphen aan den Rijn, the Netherlands), Sanofi-Aventis Netherlands B.V. (Gouda, the Netherlands) and Medtronic (Tolochenaz, Switzerland).

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.