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Steps forward in understanding gastric cancer risk
  1. Massimo Rugge1,
  2. Robert M Genta2,
  3. Peter Malfertheiner3,
  4. David Y Graham4
  1. 1Department Medicne - DIMED, University of Padova, Padova, Italy
  2. 2Pathology, Veterans Affairs North Texas Health Care System, Dallas, USA, Irving, Texas, USA
  3. 3Radiology, Ludwig Maximilians University Munich, Munchen, Germany
  4. 4Medicine (111D), Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA
  1. Correspondence to Professor Massimo Rugge, Department Medicne - DIMED, University of Padova, Padova, Italy; massimo.rugge{at}

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We thank Lenti et al for their interest in our article and their stimulating comments, grounded in their well-recognised experience with gastric autoimmunity.1 2

The main aim of our study was to assess the neoplastic risk in a cohort of autoimmune gastritis (AIG) patients in whom we excluded previous or current Helicobacter pylori infection.3

In a recent retrospective clinico-pathological report, Miceli et al studied a cohort of 270 AIG.4 A 19-year follow-up in these patients did not document any incidental gastric cancer (GC). Even after accounting for the different median follow-up times and inclusion criteria, these findings are remarkably similar to those of our long-term follow-up study (median follow-up time: 7 years, equivalent to 10 541 person-years).3 Moreover, Miceli et al document an increased neuroendocrine …

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  • Contributors All the authors were involved in the conceptualisation and editing of the text.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.