Harnessing the Vnn1 pantetheinase pathway boosts short chain fatty acids production and mucosal protection in colitis

Virginie Millet; Thomas Gensollen; Michael Maltese; Melanie Serrero; Nathalie Lesavre; Christophe Bourges; Christophe Pitaval; Sophie Cadra; Lionel Chasson; Thien Phong Vu Man; Marion Masse; Juan Jose Martinez-Garcia; Fabrice Tranchida; Laetitia Shintu; Konrad Mostert; Erick Strauss; Patricia Lepage; Mathias Chamaillard; Achille Broggi; Laurent Peyrin-Biroulet; Jean-Charles Grimaud; Philippe Naquet; Franck Galland

doi:10.1136/gutjnl-2021-325792

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Inflammatory bowel disease

Original research

Harnessing the Vnn1 pantetheinase pathway boosts short chain fatty acids production and mucosal protection in colitis

Authors

Virginie Millet Centre d’Immunologie de Marseille Luminy, Aix Marseille Université, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Marseille, France PubMed articles Google scholar articles
Thomas Gensollen Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA PubMed articles Google scholar articles
Michael Maltese Centre d’Immunologie de Marseille Luminy, Aix Marseille Université, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Marseille, France PubMed articles Google scholar articles
Melanie Serrero Gastroenterology, AP-HM Hôpital Nord, Aix Marseille Université, Marseille, France PubMed articles Google scholar articles
Nathalie Lesavre Centre d’investigation Clinique (CIC), AP-HM Hôpital Nord, Aix-Marseille Université, Marseille, France PubMed articles Google scholar articles
Christophe Bourges Genetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London, UK PubMed articles Google scholar articles
Christophe Pitaval Centre d’Immunologie de Marseille Luminy, Aix Marseille Université, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Marseille, France PubMed articles Google scholar articles
Sophie Cadra Centre d’Immunologie de Marseille Luminy, Aix Marseille Université, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Marseille, France PubMed articles Google scholar articles
Lionel Chasson Centre d’Immunologie de Marseille Luminy, Aix Marseille Université, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Marseille, France PubMed articles Google scholar articles
Thien Phong Vu Man Centre d’Immunologie de Marseille Luminy, Aix Marseille Université, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Marseille, France PubMed articles Google scholar articles
Marion Masse Centre d’Immunologie de Marseille Luminy, Aix Marseille Université, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Marseille, France PubMed articles Google scholar articles
Juan Jose Martinez-Garcia Inserm U1019 Team 7, Inserm, Lille, France PubMed articles Google scholar articles
Fabrice Tranchida ISM2, Aix Marseille Université, Centre National de la Recherche Scientifique, Centrale Marseille, Marseille, France PubMed articles Google scholar articles
Laetitia Shintu ISM2, Aix Marseille Université, Centre National de la Recherche Scientifique, Centrale Marseille, Marseille, France PubMed articles Google scholar articles
Konrad Mostert Stellenbosch University, Stellenbosch, Western Cape, South Africa PubMed articles Google scholar articles
Erick Strauss Stellenbosch University, Stellenbosch, Western Cape, South Africa PubMed articles Google scholar articles
Patricia Lepage MICALIS—UMR1319, INRA, Jouy-en-Josas, France PubMed articles Google scholar articles
Mathias Chamaillard Inserm U1019 Team 7, Inserm, Lille, France PubMed articles Google scholar articles
Achille Broggi Centre d’Immunologie de Marseille Luminy, Aix Marseille Université, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Marseille, France PubMed articles Google scholar articles
Laurent Peyrin-Biroulet Department of Gastroenterology, Inserm NGERE U1256, University Hospital of Nancy, University of Lorraine, Vandoeuvre-lès-Nancy, France PubMed articles Google scholar articles
Jean-Charles Grimaud Gastroenterology, AP-HM Hôpital Nord, Aix Marseille Université, Marseille, France PubMed articles Google scholar articles
Philippe Naquet Centre d’Immunologie de Marseille Luminy, Aix Marseille Université, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Marseille, France PubMed articles Google scholar articles
Franck Galland Centre d’Immunologie de Marseille Luminy, Aix Marseille Université, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Marseille, France PubMed articles Google scholar articles

Correspondence to Professor Franck Galland, CIML, Marseille, France; galland{at}ciml.univ-mrs.fr

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Citation

Millet V, Gensollen T, Maltese M, et al

Harnessing the Vnn1 pantetheinase pathway boosts short chain fatty acids production and mucosal protection in colitis

Gut 2023;72:1115-1128.

Publication history

Received August 4, 2021
Accepted September 5, 2022
First published September 29, 2022.

Online issue publication

May 31, 2023

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