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COVID-19 and liver injury: hypoalbuminaemia and γGT should be observed at hospital admission
  1. Sabine Weber,
  2. Alexander L Gerbes
  1. Department of Medicine II, Liver Centre Munich, LMU Klinikum, Munich, Germany
  1. Correspondence to Dr Sabine Weber, Department of Medicine II, Liver Centre Munich, LMU Klinikum, 81377 Munich, Germany;{at}

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With great interest, we read the scholarly review by Dufour et al on COVID-19 and liver disease.1 While we commend the authors for the excellent overview, we offer a slightly different view of liver injury early during infection and would like to stress some clinically relevant features.

The authors state that liver injury occurs frequently in patients with COVID-19 without previous liver disease, with mainly aspartate aminotransferase (AST) being increased at the beginning of the infection, while gamma glutamyl transferase (γGT) and alkaline phosphatase were less frequently elevated and, if so, mostly in later stages of COVID-19. However, in a prospectively collected COVID-19 cohort without underlying liver disease published …

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  • Contributors SW: first draft and revision of the manuscript. ALG: supervision and revision of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.