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Response to: Correspondence on ‘On the ethics of digestive health research in historically marginalised communities’ by Velez and Targownick
  1. Emad Mansoor1,
  2. Scott A Martin2,
  3. Abe Perez3,
  4. Vu Quang Nguyen1,
  5. Jeffry Katz1,
  6. Shubham Gupta4,
  7. Fabio Cominelli1
  1. 1Division of Gastrointestinal and Liver Disease, Case Western Reserve University Hospital, Cleveland, Ohio, USA
  2. 2Clinical Research Center, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA
  3. 3Clinical Research Center, Case Western Reserve University Hospital, Cleveland, Ohio, USA
  4. 4Division of Reconstructive Urology, Case Western Reserve University, Cleveland, Ohio, USA
  1. Correspondence to Dr Fabio Cominelli, Division of Gastrointestinal and Liver Disease, Case Western Reserve University Hospital, Cleveland, Ohio 44106, USA; fabio.cominelli{at}

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We noted with interest the response by Velez and Targownik1 to our recent letter.2 They raise concerns regarding nomenclature but also discuss the oppression, discrimination and biases faced by the lesbian, gay, bisexual, transgender, queer (or questioning), intersex and asexual (or allies) (LGBTQIA+) community. They note the history of unethical research practices, as well as a lack of representation in research. We agree with them on many of these issues. This is, in part, the impetus as to why we are engaged in community-based participatory research in which LGBTQIA+ members, advocates and allies are involved in every step of the process, including experimental design, data accrual and dissemination, which is performed in consonance with various stakeholders. We agree that the LGBTQIA+ community has poor access and outcomes attributable to, among other factors, social determinants of health, systemic biases …

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  • Contributors Study conception and design: EM and FC. Acquisition of data: SAM and AP. Analysis and interpretation: EM, SAM, AP, SG and FC. Drafting of the manuscript: EM, SAM, AP and FC. Critical revision: EM, VQN, JK, SG and FC. Study supervision: EM, VQN, JK and FC.

  • Funding This work was supported by the Clinical Component of the Administrative Core of the NIH Cleveland Digestive Diseases Research Core Center (DK097948 and administrative supplement DK097948-08S1 from NIDDK and SGMRO).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.