Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn’s disease and leads to impaired CFB cleavage and phagocytosis

Marzieh Akhlaghpour; Talin Haritunians; Shyam K More; Lisa S Thomas; Dalton T Stamps; Shishir Dube; Dalin Li; Shaohong Yang; Carol J Landers; Emebet Mengesha; Hussein Hamade; Ramachandran Murali; Alka A Potdar; Andrea J Wolf; Gregory J Botwin; Michelle Khrom; International IBD Genetics Consortium; Ashwin N Ananthakrishnan; William A Faubion; Bana Jabri; Sergio A Lira; Rodney D Newberry; Robert S Sandler; R Balfour Sartor; Ramnik J Xavier; Steven R Brant; Judy H Cho; Richard H Duerr; Mark G Lazarev; John D Rioux; L Philip Schumm; Mark S Silverberg; Karen Zaghiyan; Phillip Fleshner; Gil Y Melmed; Eric A Vasiliauskas; Christina Ha; Shervin Rabizadeh; Gaurav Syal; Nirupama N Bonthala; David A Ziring; Stephan R Targan; Millie D Long; Dermot P B McGovern; Kathrin S Michelsen

doi:10.1136/gutjnl-2023-329689

Article info

Inflammatory bowel disease

Original research

Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn’s disease and leads to impaired CFB cleavage and phagocytosis

Authors

Marzieh Akhlaghpour F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USADepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Talin Haritunians F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Shyam K More F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Lisa S Thomas F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Dalton T Stamps F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Shishir Dube F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Dalin Li F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Shaohong Yang F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Carol J Landers F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Emebet Mengesha F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Hussein Hamade F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Ramachandran Murali Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Alka A Potdar F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Andrea J Wolf F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USADepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Gregory J Botwin F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Michelle Khrom F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
International IBD Genetics Consortium
Google scholar articles
Ashwin N Ananthakrishnan Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA PubMed articles Google scholar articles
William A Faubion Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA PubMed articles Google scholar articles
Bana Jabri Biological Sciences Division, University of Chicago, Pritzker School of Medicine, Chicago, Illinois, USA PubMed articles Google scholar articles
Sergio A Lira Immunology Institute, Mount Sinai Medical Center, New York, New York, USA PubMed articles Google scholar articles
Rodney D Newberry Division of Gastroenterology, Washington Univ. Sch. of Medicine, Saint Louis, Missouri, USA PubMed articles Google scholar articles
Robert S Sandler Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina, USA PubMed articles Google scholar articles
R Balfour Sartor Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina, USA PubMed articles Google scholar articles
Ramnik J Xavier Broad Institute Harvard, Cambridge, Massachusetts, USA PubMed articles Google scholar articles
Steven R Brant Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA PubMed articles Google scholar articles
Judy H Cho Genetics and Genomics Sciences, Mt Sinai School of Medicine, New York, New York, USA PubMed articles Google scholar articles
Richard H Duerr Departments of Medicine and Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA PubMed articles Google scholar articles
Mark G Lazarev Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
John D Rioux Faculty of Medicine, Universite de Montreal, Montreal, Québec, Canada PubMed articles Google scholar articles
L Philip Schumm Dept of Health Studies, University of Chicago, Chicago, Illinois, USA PubMed articles Google scholar articles
Mark S Silverberg Division of Gastroenterology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada PubMed articles Google scholar articles
Karen Zaghiyan Division of Colorectal Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Phillip Fleshner Division of Colorectal Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Gil Y Melmed F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Eric A Vasiliauskas F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Christina Ha F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Shervin Rabizadeh Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Gaurav Syal F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Nirupama N Bonthala F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
David A Ziring Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Stephan R Targan F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Millie D Long Medicine, University of North Carolina, Chapel Hill, North Carolina, USA PubMed articles Google scholar articles
Dermot P B McGovern F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USADepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Kathrin S Michelsen F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USADepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles

Correspondence to Dr Kathrin S Michelsen, F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA; kathrin.michelsen{at}cshs.org; Professor Dermot P B McGovern; Dermot.McGovern{at}cshs.org

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Citation

Akhlaghpour M, Haritunians T, More SK, et al

Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn’s disease and leads to impaired CFB cleavage and phagocytosis

Gut Published Online First: 20 April 2023. doi: 10.1136/gutjnl-2023-329689

Publication history

Received February 10, 2023
Accepted March 9, 2023
First published April 20, 2023.

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