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We read with great interest the recently published study by Beyer et al, which established and quantified age-dependent reference values for common bile duct (CBD) and pancreatic duct (PD) diameters in a population-based study.1 The study is valuable, yet some points require further clarifications.
First, medication usage as an important factor affecting CBD and PD diameters was not adequately analysed in this study. Several studies have pointed out that medications such as opioid, calcium antagonists and nitroglycerine can cause CBD or PD dilatation.2–4 A prospective study showed that CBD diameter was significantly higher in users of opium than controls (mean±SD: 5.54±1.95 vs 4.74±1.34 mm, p<0.001) and this difference was noted with all opium types.4 The Study of Health in Pomerania (SHIP) data have shown that 1.1% participants were opioid users.5 In addition, more than …
Contributors FW: conception, analysis of data and manuscript preparation. LP: analysis of data and manuscript preparation. YL: data curation, review of the draft and final approval. All the authors approved the final version of the letter.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; internally peer reviewed.