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Targeting metalloproteases is a promising strategy to enhance immunotherapy responses by overcoming immune exclusion in hepatocellular carcinoma

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  • Contributors Both authors contributed to the design and writing of the commentary.

  • Funding MB-V was supported by Cholangiocarcinoma Foundation (CCF) Research Fellowship, and by the Postdoctoral Fellowship Grant from Ramon Areces Foundation. PB was supported by Instituto de Salud Carlos III (PI22/00147) co-financed by Fondos Feder, Gobierno de Navarra Proyecto ARNMUNE Ref: 0011–1411-2023, and a 2022 Leonardo Grant for Researchers and Cultural Creators, BBVA Foundation.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer-reviewed.

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