Article Text

Download PDFPDF
Enhanced efficiency of the ‘family index-case method’: why and when?
  1. Yifan Qiu,
  2. Wenbo Zhu,
  3. Shihan Xu,
  4. Jiayue Wang,
  5. Chanjuan Wang,
  6. Geliang Yang,
  7. Zhaoshen Li,
  8. Huiyun Zhu,
  9. Xianzhu Zhou,
  10. Yiqi Du
  1. Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China
  1. Correspondence to Prof. Yiqi Du, Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, 200433, People's Republic of China; duyiqi{at}hotmail.com; Dr. Xianzhu Zhou, Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, 200433, People's Republic of China; zhouxianzhu1994{at}163.com; Dr. Huiyun Zhu, Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, 200433, People's Republic of China; zhuhuiyun0205{at}qq.com

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

With great interest, we carefully read the article by Lei et al.1 The authors introduced a novel ‘family index-case method’ to efficiently screen for and eradicate Helicobacter pylori (H. pylori) infections by reaching out to the family members of individuals who tested positive. However, the article predominantly focused on detailing the methodology of the ‘family index-case method’, rather than providing mathematical simulations to theoretically explain the underlying mechanisms of its efficacy. Therefore, based on data from a prior household-based H. pylori epidemiological survey, we aimed to validate the familial clustering pattern of H. pylori infections and offer theoretical justification for the observed phenomenon.

From September 2021 to December 2021, a household-based H. pylori epidemiological survey was conducted in 29 provinces across mainland China.2 Familial clustering refers to the phenomenon where multiple H. pylori carriers tend to be concentrated within the same household, rather than being evenly distributed across all households. In essence, the level of familial clustering increases as infected …

View Full Text

Footnotes

  • YQ, WZ, SX, JW and CW are joint first authors.

  • GY, HZ, XZ and YD are joint senior authors.

  • Contributors XZ, YD, HZ and GY conceived and designed the study. YQ, WZ, SX and JW wrote the draft. YQ, CW and GY conducted all the analysis work. All authors gave final approval of the letter.

  • Funding This investigation was supported by a grant from the 3-year action plan for the construction of Shanghai's public health system (2023–2025), key discipline construction project (GWVI-11.1-21), Naval Medical University 'Qianghai' Innovation Team Program 'Excellent Team', 2020 Hainan Provincial Major Science and Technology Program (no. ZDKJ202005), and Changhai Hospital Changfeng Talent Plan.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.