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We thank Xu et al for their interest in our recent paper1 and for highlighting potential methodological issues.2 Our study analysed the diagnostic yield from over 380 000 gastroscopies performed in the UK to investigate the cause of patient symptoms, emphasising the low diagnostic yield from common upper gastrointestinal symptoms—namely dyspepsia and reflux—and the inefficient utilisation of gastroscopy resources.
Xu et al raise two important methodological issues: the reliance on endoscopic findings without histological confirmation for the analysis and the hierarchical categorisation of symptoms.
We agree that the lack of histological confirmation is a limitation, likely resulting in a small number of …
Footnotes
Contributors DRB drafted the letter, with input from LS and MDR.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; internally peer reviewed.