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Letter to the editor: Autoimmune gastritis may be less susceptible to cancer development than Helicobacter pylori-related gastritis based on histological analysis
  1. Zijin Liu,
  2. Jiayi Hong,
  3. Fang He
  1. Department of Gastroenterology and Hepatology, Xuanwu Hospital, Capital Medical University, Beijing, China
  1. Correspondence to Dr Fang He, Xuanwu Hospital Capital Medical University, Beijing, China; hefang760331{at}163.com

https://doi.org/10.1136/gutjnl-2024-333604

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    We read with great interest the postscript by Arai et al in response to the article by Rugge et al.1 2 The authors did a great job in comparing immunohistochemical staining results of gastric cancer (GC) due to autoimmune gastritis (AIG) and H. pylori infection. They claimed that AIG may be less susceptible to cancer development than H. pylori-related gastritis; however, a few concerns need to be addressed.

    Firstly, the authors found that the dysplastic transition (TROP2) score of AIG non-cancerous lesions …

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    Footnotes

    • Contributors ZL and JH wrote the study. FH revised the manuscript. ZL is the guarantor.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.