Metabolic reprogramming by mutant GNAS creates an actionable dependency in intraductal papillary mucinous neoplasms of the pancreas

Yuki Makino; Kimal I Rajapakshe; Benson Chellakkan Selvanesan; Takashi Okumura; Kenjiro Date; Prasanta Dutta; Lotfi Abou-Elkacem; Akiko Sagara; Jimin Min; Marta Sans; Nathaniel Yee; Megan J Siemann; Jose Enriquez; Paytience Smith; Pratip Bhattacharya; Michael Kim; Merve Dede; Traver Hart; Anirban Maitra; Fredrik Ivar Thege

doi:10.1136/gutjnl-2024-332412

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Pancreas

Original research

Metabolic reprogramming by mutant GNAS creates an actionable dependency in intraductal papillary mucinous neoplasms of the pancreas

Authors

Yuki Makino Translational Molecular Pathology, UTMDACC, Houston, Texas, USASheikh Ahmed Center for Pancreatic Cancer Research, UTMDACC, Houston, Texas, USA PubMed articles Google scholar articles
Kimal I Rajapakshe Translational Molecular Pathology, UTMDACC, Houston, Texas, USASheikh Ahmed Center for Pancreatic Cancer Research, UTMDACC, Houston, Texas, USA PubMed articles Google scholar articles
Benson Chellakkan Selvanesan Translational Molecular Pathology, UTMDACC, Houston, Texas, USASheikh Ahmed Center for Pancreatic Cancer Research, UTMDACC, Houston, Texas, USA PubMed articles Google scholar articles
Takashi Okumura Translational Molecular Pathology, UTMDACC, Houston, Texas, USASheikh Ahmed Center for Pancreatic Cancer Research, UTMDACC, Houston, Texas, USA PubMed articles Google scholar articles
Kenjiro Date Translational Molecular Pathology, UTMDACC, Houston, Texas, USASheikh Ahmed Center for Pancreatic Cancer Research, UTMDACC, Houston, Texas, USA PubMed articles Google scholar articles
Prasanta Dutta Cancer Systems Imaging, UTMDACC, Houston, Texas, USA PubMed articles Google scholar articles
Lotfi Abou-Elkacem Translational Molecular Pathology, UTMDACC, Houston, Texas, USASheikh Ahmed Center for Pancreatic Cancer Research, UTMDACC, Houston, Texas, USA PubMed articles Google scholar articles
Akiko Sagara Translational Molecular Pathology, UTMDACC, Houston, Texas, USASheikh Ahmed Center for Pancreatic Cancer Research, UTMDACC, Houston, Texas, USA PubMed articles Google scholar articles
Jimin Min Translational Molecular Pathology, UTMDACC, Houston, Texas, USASheikh Ahmed Center for Pancreatic Cancer Research, UTMDACC, Houston, Texas, USA PubMed articles Google scholar articles
Marta Sans Translational Molecular Pathology, UTMDACC, Houston, Texas, USASheikh Ahmed Center for Pancreatic Cancer Research, UTMDACC, Houston, Texas, USA PubMed articles Google scholar articles
Nathaniel Yee Translational Molecular Pathology, UTMDACC, Houston, Texas, USASheikh Ahmed Center for Pancreatic Cancer Research, UTMDACC, Houston, Texas, USA PubMed articles Google scholar articles
Megan J Siemann Translational Molecular Pathology, UTMDACC, Houston, Texas, USASheikh Ahmed Center for Pancreatic Cancer Research, UTMDACC, Houston, Texas, USA PubMed articles Google scholar articles
Jose Enriquez Cancer Systems Imaging, UTMDACC, Houston, Texas, USA PubMed articles Google scholar articles
Paytience Smith Cancer Systems Imaging, UTMDACC, Houston, Texas, USA PubMed articles Google scholar articles
Pratip Bhattacharya Cancer Systems Imaging, UTMDACC, Houston, Texas, USA PubMed articles Google scholar articles
Michael Kim Surgical Oncology, UTMDACC, Houston, Texas, USA PubMed articles Google scholar articles
Merve Dede Bioinformatics & Computational Biology, UTMDACC, Houston, Texas, USA PubMed articles Google scholar articles
Traver Hart Bioinformatics & Computational Biology, UTMDACC, Houston, Texas, USADepartment of Cancer Biology, UTMDACC, Houston, Texas, USA PubMed articles Google scholar articles
Anirban Maitra Translational Molecular Pathology, UTMDACC, Houston, Texas, USASheikh Ahmed Center for Pancreatic Cancer Research, UTMDACC, Houston, Texas, USA PubMed articles Google scholar articles
Fredrik Ivar Thege Translational Molecular Pathology, UTMDACC, Houston, Texas, USASheikh Ahmed Center for Pancreatic Cancer Research, UTMDACC, Houston, Texas, USA PubMed articles Google scholar articles

Correspondence to Dr Fredrik Ivar Thege; fithege{at}mdanderson.org; Dr Yuki Makino; ymakino{at}mdanderson.org

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Citation

Makino Y, Rajapakshe KI, Chellakkan Selvanesan B, et al

Metabolic reprogramming by mutant GNAS creates an actionable dependency in intraductal papillary mucinous neoplasms of the pancreas

Gut Published Online First: 13 September 2024. doi: 10.1136/gutjnl-2024-332412

Publication history

Received March 13, 2024
Accepted September 4, 2024
First published September 13, 2024.

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