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Variceal band ligation and carvedilol: together forever, or not?
  1. Philip D J Dunne,
  2. Ewan H Forrest,
  3. Adrian J Stanley
  1. Department of Gastroenterology, Glasgow Royal Infirmary, Glasgow, UK
  1. Correspondence to Dr Philip D J Dunne; Philip.Dunne{at}ggc.scot.nhs.uk

https://doi.org/10.1136/gutjnl-2024-333643

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    We extend our congratulations to Tevethia et al for their recently published ‘CAVARLY trial’, which suggests the combination of variceal band ligation (VBL) and carvedilol is superior to VBL or carvedilol alone in the reduction of the first episode of oesophageal variceal bleeding (OVB) in patients with high-risk varices.1 This is the first primary prophylaxis randomised control trial to examine combination therapy and provides some interesting results which require further thought.

    Despite significantly lower rates of OVB and mortality in the combination therapy group, other indicators of disease severity such as; progression of ascites, …

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    Footnotes

    • X @DunnePDJ, @ewanforrest1, @adrianstanleyGI

    • Contributors PDJD: conceptualisation and initial draft. EHF: review and comments. AS: review and comments. PDJD is the guarantor.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; internally peer reviewed.