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Online First

June 27, 2022

GI cancer
Temporality of body mass index, blood tests, comorbidities and medication use as early markers for pancreatic ductal adenocarcinoma (PDAC): a nested case–control study

Pui San Tan, Cesar Garriga, Ashley Clift, Weiqi Liao, Martina Patone, Carol Coupland, Rachael Bashford-Rogers, Shivan Sivakumar, Julia Hippisley-Cox

doi: 10.1136/gutjnl-2021-326522
Neurogastroenterology
Double-blinded randomised placebo controlled trial of enterosgel (polymethylsiloxane polyhydrate) for the treatment of IBS with diarrhoea (IBS-D)

Carol Angela Howell, Anu Kemppinen, Victoria Allgar, Matthew Dodd, Charles H Knowles, John McLaughlin, Preeti Pandya, Peter Whorwell, Elena Markaryan, Yan Yiannakou

doi: 10.1136/gutjnl-2022-327293

June 24, 2022

Pancreas
Interferon regulatory factor 1 (IRF1) controls the metabolic programmes of low-grade pancreatic cancer cells

Gabriele Alfarano, Matteo Audano, Pierluigi Di Chiaro, Chiara Balestrieri, Marta Milan, Sara Polletti, Paola Spaggiari, Alessandro Zerbi, Giuseppe Riccardo Diaferia, Nico Mitro, Gioacchino Natoli

doi: 10.1136/gutjnl-2021-325811
Letter
Transcolonic natural orifice transluminal endoscopic surgery (NOTES) is a promising technique for but not limited to periappendiceal lesions

Tao Chen, Meidong Xu

doi: 10.1136/gutjnl-2022-327901
GI cancer
Activation of NOTCH signaling via DLL1 is mediated by APE1-redox-dependent NF-κB activation in oesophageal adenocarcinoma

Lei Chen, Heng Lu, Dunfa Peng, Long Long Cao, Farah Ballout, Kannappan Srirmajayam, Zheng Chen, Ajaz Bhat, Timothy C Wang, Anthony Capobianco, Jianwen Que, Oliver Gene McDonald, Alexander Zaika, Shutian Zhang, Wael El-Rifai

doi: 10.1136/gutjnl-2022-327076

June 23, 2022

GI cancer
Blockade of interleukin 10 potentiates antitumour immune function in human colorectal cancer liver metastases

Kevin M Sullivan, Xiuyun Jiang, Prajna Guha, Christopher Lausted, Jason A Carter, Cynthia Hsu, Kevin P Labadie, Karan Kohli, Heidi L Kenerson, Sara K Daniel, Xiaowei Yan, Changting Meng, Arezou Abbasi, Marina Chan, Y David Seo, James O Park, Ian Nicholas Crispe, Raymond S Yeung, Teresa S Kim, Taranjit S Gujral, Qiang Tian, Steven C Katz, Venu G Pillarisetty

doi: 10.1136/gutjnl-2021-325808

June 22, 2022

GI cancer
Escape from cell-cell and cell-matrix adhesion dependence underscores disease progression in gastric cancer organoid models

Yin Tong, Priscilla S W Cheng, Chung Sze Or, Sarah S K Yue, Hoi Cheong Siu, Siu Lun Ho, Simon Y K Law, Wai Yin Tsui, Dessy Chan, Stephanie Ma, Siu Po Lee, Annie S Y Chan, April S Chan, Shui Wa Yun, Ho Sang Hui, Siu Tsan Yuen, Suet Yi Leung, Helen H N Yan

doi: 10.1136/gutjnl-2022-327121
Letter
Further research needed to determine first-line therapy for IBS in primary care

Anupam Rej, David S Sanders, Imran Aziz

doi: 10.1136/gutjnl-2022-328047

June 20, 2022

Letter
Hepatic events associated with sodium-glucose cotransporter-2 inhibitors in patients with type 2 diabetes: a nationwide cohort study

Sungho Bea, Han Eol Jeong, Sohee Park, Oriana H Y Yu, Yoosoo Chang, Juhee Cho, Dong Hyun Sinn, Young Min Cho, Ju-Young Shin

doi: 10.1136/gutjnl-2022-327504
Guidelines
Kyoto international consensus report on anatomy, pathophysiology and clinical significance of the gastro-oesophageal junction

Kentaro Sugano, Stuart Jon Spechler, Emad M El-Omar, Kenneth E L McColl, Kaiyo Takubo, Takuji Gotoda, Mitsuhiro Fujishiro, Katsunori Iijima, Haruhiro Inoue, Takashi Kawai, Yoshikazu Kinoshita, Hiroto Miwa, Ken-ichi Mukaisho, Kazunari Murakami, Yasuyuki Seto, Hisao Tajiri, Shobna Bhatia, Myung-Gyu Choi, Rebecca C Fitzgerald, Kwong Ming Fock, Khean-Lee Goh, Khek Yu Ho, Varocha Mahachai, Maria O'Donovan, Robert Odze, Richard Peek, Massimo Rugge, Prateek Sharma, Jose D Sollano, Michael Vieth, Justin Wu, Ming-Shiang Wu, Duowu Zou, Michio Kaminishi, Peter Malfertheiner

doi: 10.1136/gutjnl-2022-327281

June 16, 2022

Recent advances in clinical practice
Current therapies and new developments in NASH

Jean-François Dufour, Quentin M Anstee, Elisabetta Bugianesi, Stephen Harrison, Rohit Loomba, Valerie Paradis, Herbert Tilg, Vincent Wai-Sun Wong, Shira Zelber-sagi

doi: 10.1136/gutjnl-2021-326874

June 15, 2022

Commentary
Transcription factor p63, a member of the p53 family of tumour suppressors, regulates hepatic glucose metabolism

Gilles Mithieux

doi: 10.1136/gutjnl-2022-327790
Gut microbiota
Protective and aggressive bacterial subsets and metabolites modify hepatobiliary inflammation and fibrosis in a murine model of PSC

Muyiwa Awoniyi, Jeremy Wang, Billy Ngo, Vik Meadows, Jason Tam, Amba Viswanathan, Yunjia Lai, Stephanie Montgomery, Morgan Farmer, Martin Kummen, Louise Thingholm, Christoph Schramm, Corinna Bang, Andre Franke, Kun Lu, Huiping Zhou, Jasmohan S Bajaj, Phillip B Hylemon, Jenny Ting, Yury V Popov, Johannes Roksund Hov, Heather L Francis, Ryan Balfour Sartor

doi: 10.1136/gutjnl-2021-326500

June 14, 2022

Pancreas
Comparison of lumen-apposing metal stents versus double-pigtail plastic stents for infected necrotising pancreatitis

Lotte Boxhoorn, Robert C Verdonk, Marc G Besselink, Marja Boermeester, Thomas L Bollen, Stefan AW Bouwense, Vincent C Cappendijk, Wouter L Curvers, Cornelis H Dejong, Sven M van Dijk, Hendrik M van Dullemen, Casper HJ van Eijck, Erwin JM van Geenen, Muhammed Hadithi, Wouter L Hazen, Pieter Honkoop, Jeanin E van Hooft, Maarten AJM Jacobs, June EC Kievits, Marnix PM Kop, Eva Kouw, Sjoerd D Kuiken, Michiel Ledeboer, Vincent B Nieuwenhuijs, Lars E Perk, Jan-Werner Poley, Rutger Quispel, Rogier JJ de Ridder, Hjalmar C van Santvoort, Christina J Sperna Weiland, Martijn WJ Stommel, Hester C Timmerhuis, Ben J Witteman, Devica S Umans, Niels G Venneman, Frank P Vleggaar, Roy LJ van Wanrooij, Marco J Bruno, Paul Fockens, Rogier P Voermans The Dutch Pancreatitis Study Group

doi: 10.1136/gutjnl-2021-325632
Recent advances in clinical practice
COVID-19 and liver disease
Free

Jean-François Dufour, Thomas Marjot, Chiara Becchetti, Herbert Tilg

doi: 10.1136/gutjnl-2021-326792
Leading article
The future of drug development for inflammatory bowel disease: the need to ACT (advanced combination treatment)

Silvio Danese, Virginia Solitano, Vipul Jairath, Laurent Peyrin-Biroulet

doi: 10.1136/gutjnl-2022-327025

June 13, 2022

Letter
Gastric emptying study before gastric peroral endoscopic myotomy (G-POEM): can intragastric meal distribution be a predictor of success?

Francesco Vito Mandarino, Sabrina Gloria Giulia Testoni, Alberto Barchi, Gino Pepe, Dario Esposito, Lorella Fanti, Edi Viale, Paolo Biamonte, Francesco Azzolini, Silvio Danese

doi: 10.1136/gutjnl-2022-327701
Gut microbiota
6α-hydroxylated bile acids mediate TGR5 signalling to improve glucose metabolism upon dietary fiber supplementation in mice

Kassem Makki, Harald Brolin, Natalia Petersen, Marcus Henricsson, Dan Ploug Christensen, Muhammad Tanweer Khan, Annika Wahlström, Per-Olof Bergh, Valentina Tremaroli, Kristina Schoonjans, Hanns-Ulrich Marschall, Fredrik Bäckhed

doi: 10.1136/gutjnl-2021-326541
GI cancer
Phase II trial of weekly erlotinib dosing to reduce duodenal polyp burden associated with familial adenomatous polyposis

N Jewel Samadder, Nathan Foster, Ryan P McMurray, Carol A Burke, Elena Stoffel, Priyanka Kanth, Rohit Das, Marcia Cruz-Correa, E Vilar, Gautam Mankaney, Navtej Buttar, Selvi Thirumurthi, Danielle K Turgeon, Michael Sossenheimer, Michelle Westover, Ellen Richmond, Asad Umar, Gary Della'Zanna, Luz M Rodriguez, Eva Szabo, David Zahrieh, Paul J Limburg

doi: 10.1136/gutjnl-2021-326532

June 10, 2022

Commentary
Climate change: a survey of global gastroenterology society leadership

Desmond Leddin, M Bishr Omary, Geoffrey Metz, Andrew M Veitch

doi: 10.1136/gutjnl-2022-327832
Recent advances in clinical practice
Artificial intelligence in gastroenterology and hepatology: how to advance clinical practice while ensuring health equity

Eugenia Uche-Anya, Adjoa Anyane-Yeboa, Tyler M Berzin, Marzyeh Ghassemi, Folasade P May

doi: 10.1136/gutjnl-2021-326271
Editor’s quiz: GI snapshot
Gastric variceal bleeding in a patient with alcohol abuse: business as usual?

Andreas Fischer, Burcin Özdirik, Dominik Geisel, Thomas Malinka, Stefan Pahl

doi: 10.1136/gutjnl-2020-321755
Pancreas
Single-cell RNA-seq analysis reveals BHLHE40-driven pro-tumour neutrophils with hyperactivated glycolysis in pancreatic tumour microenvironment

Liwen Wang, Yihao Liu, Yuting Dai, Xiaomei Tang, Tong Yin, Chaofu Wang, Ting Wang, Lei Dong, Minmin Shi, Jiejie Qin, Meilin Xue, Yizhi Cao, Jia Liu, Pengyi Liu, Jinyan Huang, Chenlei Wen, Jun Zhang, Zhiwei Xu, Fan Bai, Xiaxing Deng, Chenghong Peng, Hao Chen, Lingxi Jiang, Saijuan Chen, Baiyong Shen

doi: 10.1136/gutjnl-2021-326070

June 08, 2022

Commentary
Adherent invasive Escherichia coli in Crohn’s disease: guilt by association?

Charles O Elson

doi: 10.1136/gutjnl-2022-327342
Small bowel
Nomenclature and diagnosis of seronegative coeliac disease and chronic non-coeliac enteropathies in adults: the Paris consensus

Annalisa Schiepatti, David S Sanders, Paola Baiardi, Giacomo Caio, Carolina Ciacci, Katri Kaukinen, Benjamin Lebwohl, Daniel Leffler, Georgia Malamut, Joseph A Murray, Kamran Rostami, Alberto Rubio-Tapia, Umberto Volta, Federico Biagi

doi: 10.1136/gutjnl-2021-326645
Letter
Maternal antibiotic exposure during pregnancy and risk of IBD in offspring: a population-based cohort study

Manasi Agrawal, Gry Poulsen, Jean-Frederic Colombel, Kristine Højgaard Allin, Tine Jess

doi: 10.1136/gutjnl-2022-327724

June 07, 2022

Letter
Great escape: how infectious SARS-CoV-2 avoids inactivation by gastric acidity and intestinal bile
Free

Malak A Esseili

doi: 10.1136/gutjnl-2021-326624
Letter
Correspondence on “PICaSSO Histologic Remission Index (PHRI) in ulcerative colitis: development of a novel simplified histological score for monitoring mucosal healing and predicting clinical outcomes and its applicability in an artificial intelligence system” by Gui et al

Emily C L Wong, Parambir S Dulai, Neeraj Narula

doi: 10.1136/gutjnl-2022-327661

May 30, 2022

Recent advances in basic science
Organoids in gastrointestinal diseases: from experimental models to clinical translation

Claudia Günther, Beate Winner, Markus F Neurath, Thaddeus S Stappenbeck

doi: 10.1136/gutjnl-2021-326560
Commentary
Guarding the gate against hyperbilirubinaemia

Eryun Zhang, Wendong Huang

doi: 10.1136/gutjnl-2022-327532

May 27, 2022

Pancreas
Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer

Maria Chiara De Santis, Luca Gozzelino, Jean Piero Margaria, Andrea Costamagna, Edoardo Ratto, Federico Gulluni, Enza Di Gregorio, Erica Mina, Nicla Lorito, Marina Bacci, Rossano Lattanzio, Gianluca Sala, Paola Cappello, Francesco Novelli, Elisa Giovannetti, Caterina Vicentini, Silvia Andreani, Pietro Delfino, Vincenzo Corbo, Aldo Scarpa, Paolo Ettore Porporato, Andrea Morandi, Emilio Hirsch, Miriam Martini

doi: 10.1136/gutjnl-2021-325117

May 25, 2022

Oesophagus
IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis

Tanay Kaymak, Berna Kaya, Philipp Wuggenig, Sandro Nuciforo, Andreas Göldi, Swiss EoE Cohort Study Group (SEECS), Franz Oswald, Julien Roux, Mario Noti, Hassan Melhem, Petr Hruz, Jan Hendrik Niess

doi: 10.1136/gutjnl-2022-327166
Hepatology
Defining the key intrahepatic gene networks in HCV infection driven by sex

Emanuele Marchi, Narayan Ramamurthy, M Azim Ansari, Caroline E Harrer, STOP-HCV, Eleanor Barnes, Paul Klenerman

doi: 10.1136/gutjnl-2021-326314

May 23, 2022

Commentary
Choosing G-POEM or other treatments for gastroparesis

Michael Camilleri

doi: 10.1136/gutjnl-2022-327545
Guidelines
British Society of Gastroenterology (BSG) and British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN) joint consensus guidelines on the diagnosis and management of eosinophilic oesophagitis in children and adults

Anjan Dhar, Hasan N Haboubi, Stephen E Attwood, Marcus K H Auth, Jason M Dunn, Rami Sweis, Danielle Morris, Jenny Epstein, Marco R Novelli, Hannah Hunter, Amanda Cordell, Sharon Hall, Jamal O Hayat, Kapil Kapur, Andrew Robert Moore, Carol Read, Sarmed S Sami, Paul J Turner, Nigel J Trudgill

doi: 10.1136/gutjnl-2022-327326
Letter
Serological responses to three doses of SARS-CoV-2 vaccination in inflammatory bowel disease

Joshua Quan, Christopher Ma, Remo Panaccione, Lindsay Hracs, Nastaran Sharifi, Michelle Herauf, Ante Makovinović, Stephanie Coward, Joseph W Windsor, Léa Caplan, Richard J M Ingram, Jamil N Kanji, Graham Tipples, Jessalyn K Holodinsky, Charles N Bernstein, Douglas J Mahoney, Sasha Bernatsky, Eric I Benchimol, Gilaad G Kaplan the STOP COVID-19 in IBD Research Group

doi: 10.1136/gutjnl-2022-327440

May 20, 2022

GI cancer
Squalene epoxidase drives cancer cell proliferation and promotes gut dysbiosis to accelerate colorectal carcinogenesis

Chuangen Li, Yong Wang, Dabin Liu, Chi Chun Wong, Olabisi Oluwabukola Coker, Xiang Zhang, Changan Liu, Yunfei Zhou, Yali Liu, Wei Kang, Ka Fai To, Joseph JY Sung, Jun Yu

doi: 10.1136/gutjnl-2021-325851

May 18, 2022

Hepatology
Novel microenvironment-based classification of intrahepatic cholangiocarcinoma with therapeutic implications

Miguel A Martin-Serrano, Benjamin Kepecs, Miguel Torres-Martin, Emily R Bramel, Philipp K Haber, Elliot Merritt, Alexander Rialdi, Nesteene Joy Param, Miho Maeda, Katherine E Lindblad, James K Carter, Marina Barcena-Varela, Vincenzo Mazzaferro, Myron Schwartz, Silvia Affo, Robert F Schwabe, Augusto Villanueva, Ernesto Guccione, Scott L Friedman, Amaia Lujambio, Anna Tocheva, Josep M Llovet, Swan N Thung, Alexander M Tsankov, Daniela Sia

doi: 10.1136/gutjnl-2021-326514

May 17, 2022

Colon
Comparison of biochemical, microbial and mucosal mRNA expression in bile acid diarrhoea and irritable bowel syndrome with diarrhoea

Michael Camilleri, Paula Carlson, Joelle BouSaba, Sanna McKinzie, Priya Vijayvargiya, Yorick Magnus, Wassel Sannaa, Xiao Jing Wang, Victor Chedid, Ting Zheng, Daniel Maselli, Jessica Atieh, Ann Taylor, Asha A Nair, Nagaswaroop Kengunte Nagaraj, Stephen Johnson, Jun Chen, Duane Burton, Irene Busciglio

doi: 10.1136/gutjnl-2022-327471
Nutrition
Hepatic p63 regulates glucose metabolism by repressing SIRT1

Maria J Gonzalez-Rellan, Eva Novoa, Natalia da Silva Lima, Amaia Rodriguez, Christelle Veyrat-Durebex, Samuel Seoane, Begoña Porteiro, Marcos F Fondevila, Uxia Fernandez, Marta Varela-Rey, Ana Senra, Cristina Iglesias, Adriana Escudero, Miguel Fidalgo, Diana Guallar, Roman Perez-Fernandez, Vincent Prevot, Markus Schwaninger, Miguel López, Carlos Dieguez, Roberto Coppari, Gema Frühbeck, Ruben Nogueiras

doi: 10.1136/gutjnl-2021-326620
Recent advances in basic science
Clinical relevance of biomarkers in cholangiocarcinoma: critical revision and future directions

Rocio I R Macias, Vincenzo Cardinale, Timothy J Kendall, Matias A Avila, Maria Guido, Cedric Coulouarn, Chiara Braconi, Adam E Frampton, John Bridgewater, Diletta Overi, Stephen P Pereira, Marco Rengo, Jakob N Kather, Angela Lamarca, Federica Pedica, Alejandro Forner, Juan W Valle, Eugenio Gaudio, Domenico Alvaro, Jesus M Banales, Guido Carpino

doi: 10.1136/gutjnl-2022-327099

May 16, 2022

Letter
Transcolonic endoscopic appendicectomy: a spectacular but unconvincing proposition

Shail Shah, Marius Taniel Paraoan

doi: 10.1136/gutjnl-2022-327708
Letter
Modelling chronic pancreatitis as a complex genetic disease in mice

Zsanett Jancsó, Alexandra Demcsák, Miklós Sahin-Tóth

doi: 10.1136/gutjnl-2022-327601

May 10, 2022

Inflammatory bowel disease
Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn’s disease

Li Zuo, Wei-Ting Kuo, Feng Cao, Sandra D Chanez-Paredes, Daniel Zeve, Prabhath Mannam, Léa Jean-François, Anne Day, W Vallen Graham, Yan Y Sweat, Nitesh Shashikanth, David T Breault, Jerrold R Turner

doi: 10.1136/gutjnl-2021-326534
GI cancer
Faecal occult blood loss accurately predicts future detection of colorectal cancer. A prognostic model

Reinier G S Meester, Hilliene J van de Schootbrugge-Vandermeer, Emilie C H Breekveldt, Lucie de Jonge, Esther Toes-Zoutendijk, Arthur Kooyker, Daan Nieboer, Christian R Ramakers, Manon C W Spaander, Anneke J van Vuuren, Ernst J Kuipers, Folkert J van Kemenade, Iris D Nagtegaal, Evelien Dekker, Monique E van Leerdam, Iris Lansdorp-Vogelaar the Dutch colorectal cancer screening working group

doi: 10.1136/gutjnl-2022-327188
Letter
Genetically proxied ketohexokinase function and risk of colorectal cancer: a Mendelian randomisation study

Amée M Buziau, Philip J Law, Gabriella Blokland, Casper Schalkwijk, Jean Scheijen, Pomme Simons, Carla van der Kallen, Simone Eussen, Pieter C Dagnelie, Marleen van Greevenbroek, Richard S Houlston, Anke Wesselius, Molly Went, Coen Stehouwer, Martijn CGJ Brouwers

doi: 10.1136/gutjnl-2021-326299

May 09, 2022

Letter
Over-the-scope clips versus standard treatment

Alan N Barkun, Loren Laine, Grigorios I Leontiadis, John R Saltzman

doi: 10.1136/gutjnl-2022-327712

May 06, 2022

Commentary
Immature neutrophils bring anti-PD-1 therapy in NASH-HCC to maturity

Michael Dudek, Frank Tacke

doi: 10.1136/gutjnl-2022-327396

May 05, 2022

GI cancer
CXCR2 inhibition enables NASH-HCC immunotherapy

Jack Leslie, John B G Mackey, Thomas Jamieson, Erik Ramon-Gil, Thomas M Drake, Frédéric Fercoq, William Clark, Kathryn Gilroy, Ann Hedley, Colin Nixon, Saimir Luli, Maja Laszczewska, Roser Pinyol, Roger Esteban-Fabró, Catherine E Willoughby, Philipp K Haber, Carmen Andreu-Oller, Mohammad Rahbari, Chaofan Fan, Dominik Pfister, Shreya Raman, Niall Wilson, Miryam Müller, Amy Collins, Daniel Geh, Andrew Fuller, David McDonald, Gillian Hulme, Andrew Filby, Xabier Cortes-Lavaud, Noha-Ehssan Mohamed, Catriona A Ford, Ximena L Raffo Iraolagoitia, Amanda J McFarlane, Misti V McCain, Rachel A Ridgway, Edward W Roberts, Simon T Barry, Gerard J Graham, Mathias Heikenwälder, Helen L Reeves, Josep M Llovet, Leo M Carlin, Thomas G Bird, Owen J Sansom, Derek A Mann

doi: 10.1136/gutjnl-2021-326259
Letter
Withdrawal of the British Society of Gastroenterology IBD risk grid for COVID-19 severity
Free

Charlie W Lees, Tariq Ahmad, Christopher Andrew Lamb, Nick Powell, Shahida Din, Rachel Cooney, Nicholas A Kennedy, Rachel Ainley, Ruth Wakeman, Christian Philipp Selinger

doi: 10.1136/gutjnl-2022-327409

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