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BMJ Journals More

Online First

December 13, 2019

PostScript
Colorectal cancer incidence in younger adults in India

Aju Mathew, Basil Baby, Kevin Wang, Bhawna Sirohi, Feintong Lei, Quan Chen, Bin Huang

doi: 10.1136/gutjnl-2019-320271

December 10, 2019

Inflammatory bowel disease
Long-term prognosis of ulcerative colitis and its temporal changes between 1986 and 2015 in a population-based cohort in the Songpa-Kangdong district of Seoul, Korea

Jae Myung Cha, Sang Hyoung Park, Kyoung Hoon Rhee, Sung Noh Hong, Young-Ho Kim, Seung In Seo, Kyung Ho Kim, Seung Kyu Jeong, Ji Hyun Lee, Sun Yong Park, Hyunju Park, Joo Sung Kim, Jong Pil Im, Hyuk Yoon, Sung Hoon Kim, Jisun Jang, Jeong Hwan Kim, Seong O Suh, Young Kyun Kim, Byong Duk Ye, Suk-Kyun Yang

doi: 10.1136/gutjnl-2019-319699
Endoscopy News
Suboptimal endoscopic cancer recognition in colorectal lesions in a national bowel screening programme

Jasper L A Vleugels, Lianne Koens, Marcel G W Dijkgraaf, Britt Houwen, Yark Hazewinkel, Paul Fockens, Evelien Dekker on behalf of the DISCOUNT study group

doi: 10.1136/gutjnl-2018-316882
Helicobacter pylori
USF1 defect drives p53 degradation during Helicobacter pylori infection and accelerates gastric carcinogenesis

Lionel Costa, Sébastien Corre, Valérie Michel, Krysten Le Luel, Julien Fernandes, Jason Ziveri, Gregory Jouvion, Anne Danckaert, Nicolas Mouchet, David Da Silva Barreira, Javier Torres, Margarita Camorlinga, Mario Milco D'Elios, Laurence Fiette, Hilde De Reuse, Marie-Dominique Galibert, Eliette Touati

doi: 10.1136/gutjnl-2019-318640

December 09, 2019

GI cancer
Systematic meta-analyses, field synopsis and global assessment of the evidence of genetic association studies in colorectal cancer

Zahra Montazeri, Xue Li, Christine Nyiraneza, Xiangyu Ma, Maria Timofeeva, Victoria Svinti, Xiangrui Meng, Yazhou He, Yacong Bo, Samuel Morgan, Sergi Castellví-Bel, Clara Ruiz-Ponte, Ceres Fernández-Rozadilla, Ángel Carracedo, Antoni Castells, Timothy Bishop, Daniel Buchanan, Mark A Jenkins, Temitope O Keku, Annika Lindblom, Fränzel J B van Duijnhoven, Anna Wu, Susan M Farrington, Malcolm G Dunlop, Harry Campbell, Evropi Theodoratou, Wei Zheng, Julian Little

doi: 10.1136/gutjnl-2019-319313

December 04, 2019

Commentary
Diagnosing pancreatic ductal adenocarcinoma using plasma extracellular vesicle RNA profiles

Adam Enver Frampton, Elisa Giovannetti

doi: 10.1136/gutjnl-2019-319896
Pancreas
Localisation of PGK1 determines metabolic phenotype to balance metastasis and proliferation in patients with SMAD4-negative pancreatic cancer

Chen Liang, Si Shi, Yi Qin, Qingcai Meng, Jie Hua, Qiangshen Hu, Shunrong Ji, Bo Zhang, Jin Xu, Xian-Jun Yu

doi: 10.1136/gutjnl-2018-317163
Hepatology
Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular carcinoma: TACTICS trial

Masatoshi Kudo, Kazuomi Ueshima, Masafumi Ikeda, Takuji Torimura, Nobukazu Tanabe, Hiroshi Aikata, Namiki Izumi, Takahiro Yamasaki, Shunsuke Nojiri, Keisuke Hino, Hidetaka Tsumura, Teiji Kuzuya, Norio Isoda, Kohichiroh Yasui, Hajime Aino, Akio Ido, Naoto Kawabe, Kazuhiko Nakao, Yoshiyuki Wada, Osamu Yokosuka, Kenichi Yoshimura, Takuji Okusaka, Junji Furuse, Norihiro Kokudo, Kiwamu Okita, Philip James Johnson, Yasuaki Arai on behalf of the TACTICS study group

doi: 10.1136/gutjnl-2019-318934

December 02, 2019

Recent advances in basic science
Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells

Nick Powell, Eirini Pantazi, Polychronis Pavlidis, Anastasia Tsakmaki, Katherine Li, Feifei Yang, Aimee Parker, Carmen Pin, Domenico Cozzetto, Danielle Minns, Emilie Stolarczyk, Svetlana Saveljeva, Rami Mohamed, Paul Lavender, Behdad Afzali, Jonathan Digby-Bell, Tsui Tjir-Li, Arthur Kaser, Joshua Friedman, Thomas T MacDonald, Gavin A Bewick, Graham M Lord

doi: 10.1136/gutjnl-2019-318483

November 29, 2019

Hepatology
Growth differentiation factor 11 attenuates liver fibrosis via expansion of liver progenitor cells

Zhen Dai, Guangqi Song, Asha Balakrishnan, Taihua Yang, Qinggong Yuan, Selina Möbus, Anna-Carina Weiss, Martin Bentler, Jimin Zhu, Xuemei Jiang, Xizhong Shen, Heike Bantel, Elmar Jaeckel, Andreas Kispert, Arndt Vogel, Anna Saborowski, Hildegard Büning, Michael Manns, Tobias Cantz, Michael Ott, Amar Deep Sharma

doi: 10.1136/gutjnl-2019-318812
Recent advances in clinical practice
Novel concepts in the pathophysiology and treatment of functional dyspepsia

Lucas Wauters, Nicholas J Talley, Marjorie M Walker, Jan Tack, Tim Vanuytsel

doi: 10.1136/gutjnl-2019-318536
PostScript
Benefit of stopping finite nucleos(t)ide analogues therapy in chronic hepatitis B patients

Yun-Fan Liaw, Wen-Juei Jeng

doi: 10.1136/gutjnl-2019-320341

November 28, 2019

Editor’s quiz: GI snapshot
Colonic strictures mimicking Crohn’s disease

Kento Takenaka, Maiko Kimura, Kazuo Ohtsuka

doi: 10.1136/gutjnl-2019-320172
Guidelines
Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG)

Kevin J Monahan, Nicola Bradshaw, Sunil Dolwani, Bianca Desouza, Malcolm G Dunlop, James E East, Mohammad Ilyas, Asha Kaur, Fiona Lalloo, Andrew Latchford, Matthew D Rutter, Ian Tomlinson, Huw J W Thomas, James Hill Hereditary CRC guidelines eDelphi consensus group

doi: 10.1136/gutjnl-2019-319915
Colon
Artificial intelligence-guided tissue analysis combined with immune infiltrate assessment predicts stage III colon cancer outcomes in PETACC08 study

Cynthia Reichling, Julien Taieb, Valentin Derangere, Quentin Klopfenstein, Karine Le Malicot, Jean-Marc Gornet, Hakim Becheur, Francis Fein, Oana Cojocarasu, Marie Christine Kaminsky, Jean Paul Lagasse, Dominique Luet, Suzanne Nguyen, Pierre-Luc Etienne, Mohamed Gasmi, Andre Vanoli, Hervé Perrier, Pierre-Laurent Puig, Jean-François Emile, Come Lepage, François Ghiringhelli

doi: 10.1136/gutjnl-2019-319292

November 27, 2019

Hepatology
USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1α/USP22 positive feedback loop upon TP53 inactivation

Sunbin Ling, Qiaonan Shan, Qifan Zhan, Qianwei Ye, Peng Liu, Shengjun Xu, Xin He, Jian Ma, Jiajia Xiang, Guangjiang Jiang, Xue Wen, Zijie Feng, Yuan Wu, Tingting Feng, Li Xu, Kangchen Chen, Xuanyu Zhang, Rongli Wei, Chenzhi Zhang, Beini Cen, Haiyang Xie, Penghong Song, Jimin Liu, Shusen Zheng, Xiao Xu

doi: 10.1136/gutjnl-2019-319616
Gut microbiota
A novel faecal Lachnoclostridium marker for the non-invasive diagnosis of colorectal adenoma and cancer

Jessie Qiaoyi Liang, Tong Li, Geicho Nakatsu, Ying-Xuan Chen, Tung On Yau, Eagle Chu, Sunny Wong, Chun Ho Szeto, Siew C Ng, Francis K L Chan, Jing-Yuan Fang, Joseph J Y Sung, Jun Yu

doi: 10.1136/gutjnl-2019-318532
Guidelines
British Society of Gastroenterology/Association of Coloproctology of Great Britain and Ireland/Public Health England post-polypectomy and post-colorectal cancer resection surveillance guidelines

Matthew D Rutter, James East, Colin J Rees, Neil Cripps, James Docherty, Sunil Dolwani, Philip V Kaye, Kevin J Monahan, Marco R Novelli, Andrew Plumb, Brian P Saunders, Siwan Thomas-Gibson, Damian J M Tolan, Sophie Whyte, Stewart Bonnington, Alison Scope, Ruth Wong, Barbara Hibbert, John Marsh, Billie Moores, Amanda Cross, Linda Sharp

doi: 10.1136/gutjnl-2019-319858
Gut microbiota
Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation

Lin-Hu Quan, Chuanhai Zhang, Meng Dong, Jun Jiang, Hongde Xu, Chunlong Yan, Xiaomeng Liu, Huiqiao Zhou, Hanlin Zhang, Li Chen, Fei-Liang Zhong, Zhao-Bo Luo, Sin-Man Lam, Guanghou Shui, Donghao Li, Wanzhu Jin

doi: 10.1136/gutjnl-2019-319114
Gut microbiota
Gut microbiota of obese subjects with Prader-Willi syndrome is linked to metabolic health

Lisa M Olsson, Christine Poitou, Valentina Tremaroli, Muriel Coupaye, Judith Aron-Wisnewsky, Fredrik Bäckhed, Karine Clément, Robert Caesar

doi: 10.1136/gutjnl-2019-319322
PostScript
Prophylactic angiographic embolisation after endoscopic treatment of bleeding for high-risk peptic ulcers: what are the more appropriate indications?

Huan Tong, Tian Lan, Cheng-Wei Tang

doi: 10.1136/gutjnl-2019-319818

November 22, 2019

Neurogastroenterology
microRNA overexpression in slow transit constipation leads to reduced Na_V1.5 current and altered smooth muscle contractility

Amelia Mazzone, Peter R Strege, Simon J Gibbons, Constanza Alcaino, Vikram Joshi, Andrew J Haak, Daniel J Tschumperlin, Cheryl E Bernard, Robert R Cima, David W Larson, Heidi K Chua, Rondell P Graham, Mona El Refaey, Peter J Mohler, Yujiro Hayashi, Tamas Ordog, Stefan Calder, Peng Du, Gianrico Farrugia, Arthur Beyder

doi: 10.1136/gutjnl-2019-318747

November 21, 2019

Small bowel
Suppression of enteroendocrine cell glucagon-like peptide (GLP)-1 release by fat-induced small intestinal ketogenesis: a mechanism targeted by Roux-en-Y gastric bypass surgery but not by preoperative very-low-calorie diet

Ville Wallenius, Erik Elias, Erik Elebring, Bauke Haisma, Anna Casselbrant, Pierre Larraufie, Emma Spak, Frank Reimann, Carel W le Roux, Neil G Docherty, Fiona M Gribble, Lars Fändriks

doi: 10.1136/gutjnl-2019-319372

November 20, 2019

PostScript
Individualised tailored assessment of therapeutic alternatives for HCC patients within the Milan criteria

Ningning Zhang, Wentao Jiang, Yamin Zhang, Tian-Qiang Song, Jiayu Lv, Jie Gu, Ying Wu, Jing Qian, Dazhi Tian, Qingjun Guo, Li Zhang, Jisan Sun, Yan Xie, Zhenglu Wang, Xin Sun, Zhongfang Yan, Yonghe Zhou, Jianyong Liu, Yibo Qiu, Bing Yang, Zhongyang Shen, Wei Lu

doi: 10.1136/gutjnl-2019-320073

November 19, 2019

Coeliac disease
Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study

Katri Lindfors, Jake Lin, Hye-Seung Lee, Heikki Hyöty, Matti Nykter, Kalle Kurppa, Edwin Liu, Sibylle Koletzko, Marian Rewers, William Hagopian, Jorma Toppari, Annette-Gabriele Ziegler, Beena Akolkar, Jeffrey P Krischer, Joseph F Petrosino, Richard E Lloyd, Daniel Agardh the TEDDY Study Group

doi: 10.1136/gutjnl-2019-319809
GI cancer
Genomic and transcriptomic profiling of carcinogenesis in patients with familial adenomatous polyposis

Jingyun Li, Rui Wang, Xin Zhou, Wendong Wang, Shuai Gao, Yunuo Mao, Xinglong Wu, Limei Guo, Haijing Liu, Lu Wen, Wei Fu, Fuchou Tang

doi: 10.1136/gutjnl-2019-319438
Editor’s quiz: GI snapshot
Obscure GI bleeding in a young man

Fady Daniel, Roni Aoun, Rayan Rammal

doi: 10.1136/gutjnl-2019-319870

November 14, 2019

Hepatology
miR-541 potentiates the response of human hepatocellular carcinoma to sorafenib treatment by inhibiting autophagy

Wen-Ping Xu, Jin-Pei Liu, Ji-Feng Feng, Chang-Peng Zhu, Yuan Yang, Wei-Ping Zhou, Jin Ding, Chen-Kai Huang, Ya-Lu Cui, Chen-Hong Ding, Xin Zhang, Bin Lu, Wei-Fen Xie

doi: 10.1136/gutjnl-2019-318830
Hepatology
Hepatitis E virus replication in human intestinal cells

Olivier Marion, Sebastien Lhomme, Manon Nayrac, Martine Dubois, Mélanie Pucelle, Mary Requena, Marion Migueres, Florence Abravanel, Jean Marie Peron, Nicolas Carrere, Bertrand Suc, Pierre Delobel, Nassim Kamar, Jacques Izopet

doi: 10.1136/gutjnl-2019-319004

November 13, 2019

Hepatology
Rilpivirine attenuates liver fibrosis through selective STAT1-mediated apoptosis in hepatic stellate cells

Alberto Martí-Rodrigo, Fernando Alegre, Ángela B Moragrega, Francisco García-García, Pablo Martí-Rodrigo, Anabel Fernández-Iglesias, Jordi Gracia-Sancho, Nadezda Apostolova, Juan V Esplugues, Ana Blas-García

doi: 10.1136/gutjnl-2019-318372
PostScript
Elevated interferon-gamma levels during pregnancy are associated with adverse maternofetal outcomes in IBD

Humberto Jijon, Aito Ueno, Nastaran Sharifi, Yvette Leung, Subrata Ghosh, Cynthia Seow

doi: 10.1136/gutjnl-2019-319656
Colon
STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis

Christina Heichler, Kristina Scheibe, Anabel Schmied, Carol I Geppert, Benjamin Schmid, Stefan Wirtz, Oana-Maria Thoma, Viktoria Kramer, Maximilian J Waldner, Christian Büttner, Henner F Farin, Marina Pešić, Ferdinand Knieling, Susanne Merkel, Anika Grüneboom, Matthias Gunzer, Robert Grützmann, Stefan Rose-John, Sergei B Koralov, George Kollias, Michael Vieth, Arndt Hartmann, Florian R Greten, Markus F Neurath, Clemens Neufert

doi: 10.1136/gutjnl-2019-319200

November 12, 2019

Endoscopy
Endoscopic mucosal resection is effective for laterally spreading lesions at the anorectal junction

Neal Shahidi, Mayenaaz Sidhu, Sergei Vosko, W Arnout van Hattem, Iddo Bar-Yishay, Scott Schoeman, David J Tate, Bronte Holt, Luke F Hourigan, Eric YT Lee, Nicholas G Burgess, Michael J Bourke

doi: 10.1136/gutjnl-2019-319785
PostScript
Differences in delta virus hepatitis diagnosis methods and its effect on the hepatitis D prevalence

Dan-Ting Shen, Hemant Goyal, Hua-Guo Xu

doi: 10.1136/gutjnl-2019-320159

November 08, 2019

Editor’s quiz: GI snapshot
Curious case of gut dysmotility

Phey Shen Lee, Laura Jopson, Stephanie J Needham, Christopher G Mountford, Nick P Thompson

doi: 10.1136/gutjnl-2019-319840

October 31, 2019

Hepatology
Comparison of tenofovir and entecavir on the risk of hepatocellular carcinoma and mortality in treatment-naïve patients with chronic hepatitis B in Korea: a large-scale, propensity score analysis

Sung Won Lee, Jung Hyun Kwon, Hae Lim Lee, Sun Hong Yoo, Hee Chul Nam, Pil Soo Sung, Soon Woo Nam, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Nam Ik Han, Jeong Won Jang

doi: 10.1136/gutjnl-2019-318947

October 30, 2019

PostScript
Putative function of goblet cells as epithelial sealing in ischaemia/reperfusion-induced intestinal barrier dysfunction

Yuk Lung Wong, Lars Hummitzsch, Ingmar Lautenschläger, Karina Zitta, Thilo Wedel, François Cossais, Clemens Schafmayer, Thomas Becker, Rouven Berndt, Matthias Gruenewald, Norbert Weiler, Markus Steinfath, Martin Albrecht

doi: 10.1136/gutjnl-2019-319770

October 25, 2019

PostScript
Are the 5-hydroxymethylcytosine-based wd-scores really superior over α-fetoprotein for the early diagnosis of hepatocellular carcinoma?

Yongpeng Chen, Xiao-Yu Lin

doi: 10.1136/gutjnl-2019-319853
Gastroduodenal
Endoscopic duodenal mucosal resurfacing for the treatment of type 2 diabetes mellitus: one year results from the first international, open-label, prospective, multicentre study

Annieke C G van Baar, Frits Holleman, Laurent Crenier, Rehan Haidry, Cormac Magee, David Hopkins, Leonardo Rodriguez Grunert, Manoel Galvao Neto, Paulina Vignolo, Bu’Hussain Hayee, Ann Mertens, Raf Bisschops, Jan Tijssen, Max Nieuwdorp, Caterina Guidone, Guido Costamagna, Jacques Devière, Jacques J G H M Bergman

doi: 10.1136/gutjnl-2019-318349
PostScript
Gut mycobiome of primary sclerosing cholangitis patients is characterised by an increase of Trichocladium griseum and Candida species

Malte Christoph Rühlemann, Miriam Emmy Leni Solovjeva, Roman Zenouzi, Timur Liwinski, Martin Kummen, Wolfgang Lieb, Johannes Roksund Hov, Christoph Schramm, Andre Franke, Corinna Bang

doi: 10.1136/gutjnl-2019-320008

October 18, 2019

Editor’s quiz: GI snapshot
Unexplained liver dysfunction in a young Chinese man with eosinophilia

Zhuwan Lyu, Qi Miao, Pan Jiang, Xiao Xiao, Xiaoyu Chen, Qixia Wang, Xiong Ma

doi: 10.1136/gutjnl-2019-319815
Pancreas
Loss of Setd2 promotes Kras-induced acinar-to-ductal metaplasia and epithelia–mesenchymal transition during pancreatic carcinogenesis

Ningning Niu, Ping Lu, Yanlin Yang, Ruizhe He, Li Zhang, Juanjuan Shi, Jinghua Wu, Minwei Yang, Zhi-Gang Zhang, Li-Wei Wang, Wei-Qiang Gao, Aida Habtezion, Gary Guishan Xiao, Yongwei Sun, Li Li, Jing Xue

doi: 10.1136/gutjnl-2019-318362

October 15, 2019

Endoscopy news
New artificial intelligence system: first validation study versus experienced endoscopists for colorectal polyp detection

Cesare Hassan, Michael B Wallace, Prateek Sharma, Roberta Maselli, Vincenzo Craviotto, Marco Spadaccini, Alessandro Repici

doi: 10.1136/gutjnl-2019-319914
Commentary
Of FACT complex and oxidative stress response: a KEAP1/NRF2-dependent novel mechanism sustaining hepatocellular carcinoma progression

Beatrice Foglia, Maurizio Parola

doi: 10.1136/gutjnl-2019-319609
Commentary
Personalised screening for colorectal cancer, ready for take-off

Ernst J Kuipers, Esmée J Grobbee

doi: 10.1136/gutjnl-2019-319677

October 14, 2019

PostScript
Immune checkpoint inhibitors: use them early, combined and instead of TACE?

Enrico N De Toni

doi: 10.1136/gutjnl-2019-319658
PostScript
Early detection and risk stratification of gastric cancer are likely to be refined with biopsies targeted through high-resolution-enhanced imaging

Marnix Jansen, Matthew Banks

doi: 10.1136/gutjnl-2019-319921

October 10, 2019

Gut microbiota
No distinct microbiome signature of irritable bowel syndrome found in a Swedish random population

Luisa W Hugerth, Anna Andreasson, Nicholas J Talley, Anna M Forsberg, Lars Kjellström, Peter Thelin Schmidt, Lars Agreus, Lars Engstrand

doi: 10.1136/gutjnl-2019-318717

October 05, 2019

Gut microbiota
Gut microbiota shape ‘inflamm-ageing’ cytokines and account for age-dependent decline in DNA damage repair

Avital Guedj, Yael Volman, Anat Geiger-Maor, Julia Bolik, Neele Schumacher, Sven Künzel, John F Baines, Yuval Nevo, Sharona Elgavish, Eithan Galun, Hagai Amsalem, Dirk Schmidt-Arras, Jacob Rachmilewitz

doi: 10.1136/gutjnl-2019-318491
PostScript
EMR achieves similar oncological outcomes as ESD for gastric neoplasia of <1cm, requiring less expertise, training and time

Matthew Banks, Noriya Uedo, Pradeep Bhandari, Takuji Gotoda

doi: 10.1136/gutjnl-2019-319925

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