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Online First

February 01, 2023

Letter
In silico method to maximise the biological potential of understudied metabolomic biomarkers: a study in pre-eclampsia

Huimin Zheng, Feihong Mai, Siyou Zhang, Zixin Lan, Zhang Wang, Shanwei Lan, Renfang Zhang, Dong Liang, Guoqiang Chen, Xia Chen, Yinglin Feng

doi: 10.1136/gutjnl-2022-329312

January 31, 2023

Pancreas
Activated regulatory T-cells promote duodenal bacterial translocation into necrotic areas in severe acute pancreatitis

Juliane Glaubitz, Anika Wilden, Fabian Frost, Sabine Ameling, Georg Homuth, Hala Mazloum, Malte Christoph Rühlemann, Corinna Bang, Ali A Aghdassi, Christoph Budde, Tilmann Pickartz, Andre Franke, Barbara M Bröker, Uwe Voelker, Julia Mayerle, Markus M Lerch, Frank-Ulrich Weiss, Matthias Sendler

doi: 10.1136/gutjnl-2022-327448
Recent advances in basic science
Microbial transmission, colonisation and succession: from pregnancy to infancy

Liwen Xiao, Fangqing Zhao

doi: 10.1136/gutjnl-2022-328970

January 30, 2023

GI cancer
Targeting m⁶A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer

Yi Bao, Jianning Zhai, Huarong Chen, Chi Chun Wong, Cong Liang, Yanqiang Ding, Dan Huang, Hongyan Gou, Danyu Chen, Yasi Pan, Wei Kang, Ka Fai To, Jun Yu

doi: 10.1136/gutjnl-2022-328845
Inflammatory bowel disease
Proton pump inhibitors and the risk of inflammatory bowel disease: population-based cohort study

Devin Abrahami, Richeek Pradhan, Hui Yin, Russell Yanofsky, Emily Gibson McDonald, Alain Bitton, Laurent Azoulay

doi: 10.1136/gutjnl-2022-328866
Hepatology
Phenotypic CD8 T cell profiling in chronic hepatitis B to predict HBV-specific CD8 T cell susceptibility to functional restoration in vitro

Marzia Rossi, Andrea Vecchi, Camilla Tiezzi, Valeria Barili, Paola Fisicaro, Amalia Penna, Ilaria Montali, Stephane Daffis, Simon P Fletcher, Anuj Gaggar, Jonathan Medley, Michael Graupe, Latesh Lad, Alessandro Loglio, Roberta Soffredini, Marta Borghi, Teresa Pollicino, Cristina Musolino, Arianna Alfieri, Federica Brillo, Diletta Laccabue, Marco Massari, Chiara Boarini, Gianluca Abbati, Giuseppe Pedrazzi, Gabriele Missale, Pietro Lampertico, Carlo Ferrari, Carolina Boni

doi: 10.1136/gutjnl-2022-327202
Letter
Inflammation-associated gut microbiome in postacute sequelae of SARS-CoV-2 points towards new therapeutic targets

Valdirene Leao Carneiro, Katherine M Littlefield, Renee Watson, Brent E Palmer, Catherine Lozupone

doi: 10.1136/gutjnl-2022-328757

January 27, 2023

Commentary
Cracking the host functional network involved in hepatitis B virus cccDNA biology

Barbara Testoni, Alexander Ploss

doi: 10.1136/gutjnl-2022-329185
Hepatology
Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice

Tim Hendrikx, Sonja Lang, Dragana Rajcic, Yanhan Wang, Sara McArdle, Kenneth Kim, Zbigniew Mikulski, Bernd Schnabl

doi: 10.1136/gutjnl-2022-328265
Hepatology
Quantification of the hepatitis B virus cccDNA: evidence-based guidelines for monitoring the key obstacle of HBV cure

Lena Allweiss, Barbara Testoni, Mei Yu, Julie Lucifora, Chunkyu Ko, Bingqian Qu, Marc Lütgehetmann, Haitao Guo, Stephan Urban, Simon P Fletcher, Ulrike Protzer, Massimo Levrero, Fabien Zoulim, Maura Dandri

doi: 10.1136/gutjnl-2022-328380
Recent advances in clinical practice
Understanding neuroimmune interactions in disorders of gut–brain interaction: from functional to immune-mediated disorders

Tim Vanuytsel, Premysl Bercik, Guy Boeckxstaens

doi: 10.1136/gutjnl-2020-320633
Letter
Over-the-scope clips versus standard therapy in upper gastrointestinal bleeding

Benjamin Meier, Arthur Schmidt, Karel Caca

doi: 10.1136/gutjnl-2022-329296
Hepatology
Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade

Claire Conche, Fabian Finkelmeier, Marina Pešić, Adele M Nicolas, Tim W Böttger, Kilian B Kennel, Dominic Denk, Fatih Ceteci, Kathleen Mohs, Esther Engel, Özge Canli, Yasamin Dabiri, Kai-Henrik Peiffer, Stefan Zeuzem, Gabriela Salinas, Thomas Longerich, Huan Yang, Florian R Greten

doi: 10.1136/gutjnl-2022-327909

January 25, 2023

Hepatology
Randomised phase 2 study (JADE) of the HBV capsid assembly modulator JNJ-56136379 with or without a nucleos(t)ide analogue in patients with chronic hepatitis B infection

Harry L A Janssen, Jinlin Hou, Tarik Asselah, Henry L Y Chan, Fabien Zoulim, Yasuhito Tanaka, Ewa Janczewska, Ronald G Nahass, Stefan Bourgeois, Maria Buti, Pietro Lampertico, Oliver Lenz, Thierry Verbinnen, Joris Vandenbossche, Willem Talloen, Ronald Kalmeijer, Maria Beumont, Michael Biermer, Umesh Shukla

doi: 10.1136/gutjnl-2022-328041
Letter
Is the significant risk of perioperative complications associated with radical surgery following non-curative endoscopic submucosal dissection for early colorectal cancer still acceptable?

Matteo Rottoli, Alice Gori, Gianluca Pellino, Maria Elena Flacco, Antonino Spinelli, Gilberto Poggioli COVID-CRC Study Group

doi: 10.1136/gutjnl-2022-328076

January 24, 2023

Letter
Haemorrhoidal disease reduces the risk of diverticular disease and irritable bowel syndrome: a Mendelian randomisation study

Zijun Zhu, Xinyu Chen, Chao Wang, Sainan Zhang, Liang Cheng

doi: 10.1136/gutjnl-2022-329307
Letter
Conclusion that autoimmune gastritis does not predispose to gastric cancer is unproven

Helge Lyder Waldum

doi: 10.1136/gutjnl-2022-329323

January 23, 2023

Helicobacter pylori
Large-scale, national, family-based epidemiological study on Helicobacter pylori infection in China: the time to change practice for related disease prevention

Xian-Zhu Zhou, Nong-Hua Lyu, Hui-Yun Zhu, Quan-Cai Cai, Xiang-Yu Kong, Pei Xie, Li-Ya Zhou, Song-Ze Ding, Zhao-Shen Li, Yi-Qi Du On behalf of the National Clinical Research Center for Digestive Diseases (Shanghai), Gastrointestinal Early Cancer Prevention & Treatment Alliance of China (GECA), Helicobacter pylori Study Group of Chinese Society of Gastroenterology and Chinese Alliance for Helicobacter pylori Study.

doi: 10.1136/gutjnl-2022-328965

January 19, 2023

Letter
Effect of rapid colonic transit on stool microbiome and short-chain fatty acids in diarrhoea-predominant irritable bowel syndrome

Joelle BouSaba, Ting Zheng, Saam Dilmaghani, Stephen Johnson, Jun Chen, Michael Camilleri

doi: 10.1136/gutjnl-2022-329359

January 17, 2023

Gut microbiota
Gut commensal Parabacteroides distasonis alleviates inflammatory arthritis

Haijian Sun, Yunke Guo, Haidan Wang, Ailing Yin, Jing Hu, Tianjie Yuan, Shuxin Zhou, Weichen Xu, Peng Wei, Shusheng Yin, Panru Liu, Xi Guo, Yizhao Tang, Yujiao Yan, Zichen Luo, Majie Wang, Qingqing Liang, Peng Wu, Aifeng Zhang, Zhuxiu Zhou, Yueyue Chen, Yongming Li, Jing Li, Jinjun Shan, Wei Zhou

doi: 10.1136/gutjnl-2022-327756

January 16, 2023

Gut microbiota
Akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism

Noëmie Daniel, Andrew T Gewirtz, Benoit Chassaing

doi: 10.1136/gutjnl-2021-326835

January 11, 2023

Hepatology
S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos

Xia Wang, Hongyang Huang, Karen Man-Fong Sze, Jin Wang, Lu Tian, Jingyi Lu, Yu-Man Tsui, Hoi Tang Ma, Eva Lee, Ao Chen, Joyce Lee, Ying Wang, Judy Wai Ping Yam, Tan-To Cheung, Xinyuan Guan, Irene Oi-Lin Ng

doi: 10.1136/gutjnl-2022-327998
Pancreas
Preclinical mouse model of a misfolded PNLIP variant develops chronic pancreatitis

Guoying Zhu, Steven J Wilhelm, Leah G George, Brett M Cassidy, Sammy Zino, Cliff J Luke, Mina Hanna, Stephen Stone, Nhung Phan, Neel Matiwala, Samuel J Ballentine, Mark E Lowe, Xunjun Xiao

doi: 10.1136/gutjnl-2022-327960

January 10, 2023

Gut microbiota
Gestational diabetes is driven by microbiota-induced inflammation months before diagnosis

Yishay Pinto, Sigal Frishman, Sondra Turjeman, Adi Eshel, Meital Nuriel-Ohayon, Oshrit Shrossel, Oren Ziv, William Walters, Julie Parsonnet, Catherine Ley, Elizabeth L Johnson, Krithika Kumar, Ron Schweitzer, Soliman Khatib, Faiga Magzal, Efrat Muller, Snait Tamir, Kinneret Tenenbaum-Gavish, Samuli Rautava, Seppo Salminen, Erika Isolauri, Or Yariv, Yoav Peled, Eran Poran, Joseph Pardo, Rony Chen, Moshe Hod, Elhanan Borenstein, Ruth E Ley, Betty Schwartz, Yoram Louzoun, Eran Hadar, Omry Koren

doi: 10.1136/gutjnl-2022-328406
Commentary
‘Invisible’ immune checkpoint molecule causing resistance to anti-PD1 therapy in HCC

Tim F Greten

doi: 10.1136/gutjnl-2022-329099

January 09, 2023

Inflammatory bowel disease
Antibiotic use as a risk factor for inflammatory bowel disease across the ages: a population-based cohort study

Adam S Faye, Kristine Højgaard Allin, Aske T Iversen, Manasi Agrawal, Jeremiah Faith, Jean-Frederic Colombel, Tine Jess

doi: 10.1136/gutjnl-2022-327845

January 06, 2023

Editor’s quiz: GI snapshot
GI snapshot: weight loss and altered bowel habit in a 72-year-old woman

Lyman Lin, Robert Gilmore, Chamara Basnayake

doi: 10.1136/gutjnl-2022-329084

January 05, 2023

Endoscopy
Production and possible reduction of greenhouse gases produced during GI endoscopy activity: a systematic review of available literature

Abhilash Perisetti, Madhav Desai, Michael J Bourke, Ian Penman, Alessandro Repici, Duvvur Nageshwar Reddy, Hisao Tajiri, Douglas K Rex, Cesare Hassan, Prateek Sharma

doi: 10.1136/gutjnl-2022-328369
Letter
Gut microbiome and dietary fibre intake strongly associate with IgG function and maturation following SARS-CoV-2 mRNA vaccination

Genelle Rose Healey, Liam Golding, Alana Schick, Abdelilah Majdoubi, Pascal M Lavoie, Bruce Andrew Vallance

doi: 10.1136/gutjnl-2022-328556

January 04, 2023

Hepatology
Diagnostic accuracy of FibroScan-AST (FAST) score for the non-invasive identification of patients with fibrotic non-alcoholic steatohepatitis: a systematic review and meta-analysis

Federico Ravaioli, Elton Dajti, Alessandro Mantovani, Philip Noel Newsome, Giovanni Targher, Antonio Colecchia

doi: 10.1136/gutjnl-2022-328689

January 03, 2023

Hepatology
Distinct single-cell immune ecosystems distinguish true and de novo HBV-related hepatocellular carcinoma recurrences

Shuling Chen, Cheng Huang, Guanrui Liao, Huichuan Sun, Yubin Xie, Changyi Liao, Jianping Wang, Minghui He, Huanjing Hu, Zihao Dai, Xiaoxue Ren, Xuezhen Zeng, Zhilong Lin, Guo-Pei Zhang, Wenxuan Xie, Shunli Shen, Shaoqiang Li, Sui Peng, Dong-Ming Kuang, Qiang Zhao, Dan G Duda, Ming Kuang

doi: 10.1136/gutjnl-2022-328428
Commentary
Disentangling tryptophan metabolism in inflammatory bowel diseases

Christoph Becker, Timon Erik Adolph

doi: 10.1136/gutjnl-2022-328853

January 02, 2023

Hepatology
MicroRNA-223 attenuates hepatocarcinogenesis by blocking hypoxia-driven angiogenesis and immunosuppression

Yaojie Fu, Bryan Mackowiak, Dechun Feng, Hongkun Lu, Yukun Guan, Taylor Lehner, Hongna Pan, Xin Wei Wang, Yong He, Bin Gao

doi: 10.1136/gutjnl-2022-327924

December 30, 2022

Gut microbiota
Gut microbiota influence anastomotic healing in colorectal cancer surgery through modulation of mucosal proinflammatory cytokines

Roy Hajjar, Emmanuel Gonzalez, Gabriela Fragoso, Manon Oliero, Ahmed Amine Alaoui, Annie Calvé, Hervé Vennin Rendos, Souad Djediai, Thibault Cuisiniere, Patrick Laplante, Claire Gerkins, Ayodeji Samuel Ajayi, Khoudia Diop, Nassima Taleb, Sophie Thérien, Frédéricke Schampaert, Hefzi Alratrout, François Dagbert, Rasmy Loungnarath, Herawaty Sebajang, Frank Schwenter, Ramses Wassef, Richard Ratelle, Eric Debroux, Jean-François Cailhier, Bertrand Routy, Borhane Annabi, Nicholas J B Brereton, Carole Richard, Manuela M Santos

doi: 10.1136/gutjnl-2022-328389
Letter
Cut-off value of clarithromycin resistance in the treatment of Helicobacter pylori infection: how low is low?

Ping-I Hsu, Seng-Kee Chuah, Yoshio Yamaoka, Deng-Chyang Wu

doi: 10.1136/gutjnl-2022-329253

December 22, 2022

Colon
Irritable bowel syndrome: treatment based on pathophysiology and biomarkers

Michael Camilleri, Guy Boeckxstaens

doi: 10.1136/gutjnl-2022-328515

December 15, 2022

Hepatology
Cardiovascular disease risk in paediatric and young adult non-alcoholic fatty liver disease

Tracey G Simon, Bjorn Roelstraete, Naim Alkhouri, Hannes Hagström, Johan Sundström, Jonas F Ludvigsson

doi: 10.1136/gutjnl-2022-328105

December 14, 2022

Editor’s quiz: GI snapshot
Bad gut feeling: a case of recurrent abdominal pain in a young man

Stela Celaj, Harkirat Singh

doi: 10.1136/gutjnl-2022-329030

December 13, 2022

Neurogastroenterology
Changes in signalling from faecal neuroactive metabolites following dietary modulation of IBS pain

Caroline J Tuck, Amal Abu Omar, Giada De Palma, Samira Osman, Nestor N Jiménez-Vargas, Yang Yu, Sean MP Bennet, Cintya Lopez-Lopez, Josue O Jaramillo-Polanco, Corey C Baker, Aidan SW Bennett, Mabel Guzman-Rodriguez, Quentin Tsang, Taylor Alward, Sebastien Rolland, Celine Morissette, Elena F Verdu, Premysl Bercik, Stephen J Vanner, Alan E Lomax, David E Reed

doi: 10.1136/gutjnl-2022-327260
Commentary
Meltdown of the cold tumour microenvironment: a new ‘translational’ approach to augment immunotherapy efficacy

Alfred Sze-Lok Cheng

doi: 10.1136/gutjnl-2022-328861
Commentary
Engineered IFN-α and anti-PDL1 containing compounds to target the liver and restore antiviral protection for HBV cure

Paola Fisicaro

doi: 10.1136/gutjnl-2022-328902

December 09, 2022

Letter
AGR2 protein expression in colorectal tumour epithelialcompartment

Eric Chevet, F Bassal, Stéphanie Beq, Benjamin Bonhomme, Emeric Boisteau, Julien Calloch, Dominique Cazals-Hatem, Frederic Delom, Delphine Fessart, Serge Evrard, Roman Hrstka, ted hupp, Astrid Lièvre, Edouard Louis, Jeremie Mariau, Marie-Alice Meuwis, Eric Ogier-Denis, Valerie Paradis, Simon Pernot, R Pineau, Xavier Treton, Valerie Velasco, Sophie Vieujean

doi: 10.1136/gutjnl-2022-328739
Neurogastroenterology
Post COVID-19 irritable bowel syndrome
Free

Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yağcı, Husnu Pullukcu, Berrin Yalınbas Kaya, Ali Tureyen, İbrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Calıskan, Goksel Bengi, Esra Ergun Alıs, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjölund, Navkiran Tornkvist, Uday C Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara the GI-COVID19 study group

doi: 10.1136/gutjnl-2022-328483
Hepatology
Cell-based cccDNA reporter assay combined with functional genomics identifies YBX1 as HBV cccDNA host factor and antiviral candidate target

Eloi R Verrier, Gaëtan Ligat, Laura Heydmann, Katharina Doernbrack, Julija Miller, Anne Maglott-Roth, Frank Jühling, Houssein El Saghire, Margaux J Heuschkel, Naoto Fujiwara, Sen-Yung Hsieh, Yujin Hoshida, David E Root, Emanuele Felli, Patrick Pessaux, Atish Mukherji, Laurent Mailly, Catherine Schuster, Laurent Brino, Michael Nassal, Thomas F. Baumert

doi: 10.1136/gutjnl-2020-323665
Endoscopy
EUS-guided drainage of large walled-off pancreatic necroses using plastic versus lumen-apposing metal stents: a single-centre randomised controlled trial

John Gásdal Karstensen, Srdan Novovic, Erik Feldager Hansen, Annette Bojer Jensen, Henrik Lovendahl Jorgensen, Morten Laksafoss Lauritsen, Mikkel Parsberg Werge, Palle Nordblad Schmidt

doi: 10.1136/gutjnl-2022-328225

December 08, 2022

Editor’s quiz: GI snapshot
Innumerable nodules in all parts of the small intestine

Jara van Veghel, Peter van Zwam, Ramon-Michel Schreuder

doi: 10.1136/gutjnl-2022-328269

December 06, 2022

Inflammatory bowel disease
Lifestyle factors for the prevention of inflammatory bowel disease

Emily W Lopes, Simon S M Chan, Mingyang Song, Jonas F Ludvigsson, Niclas Håkansson, Paul Lochhead, Allan Clark, Kristin E Burke, Ashwin N Ananthakrishnan, Amanda J Cross, Domenico Palli, Manuela M Bergmann, James M Richter, Andrew T Chan, Ola Olén, Alicja Wolk, Hamed Khalili EPIC-IBD investigators

doi: 10.1136/gutjnl-2022-328174

December 05, 2022

Helicobacter pylori
Empirical rescue treatment of Helicobacter pylori infection in third and subsequent lines: 8-year experience in 2144 patients from the European Registry on H. pylori management (Hp-EuReg)

Diego Burgos-Santamaría, Olga P Nyssen, Antonio Gasbarrini, Dino Vaira, Ángeles Pérez-Aisa, Luís Rodrigo, Rinaldo Pellicano, Alma Keco-Huerga, Manuel Pabón-Carrasco, Manuel Castro-Fernandez, Doron Boltin, Jesus Barrio, Perminder Phull, Juozas Kupcinskas, Laimas Jonaitis, Inmaculada Ortiz-Polo, Bojan Tepes, Alfredo J Lucendo, José María Huguet, Miguel Areia, Natasa Brglez Jurecic, Maja Denkovski, Luís Bujanda, June Ramos-San Román, Antonio Cuadrado-Lavín, Judith Gomez-Camarero, Manuel Alfonso Jiménez Moreno, Angel Lanas, Samuel Jesús Martinez-Dominguez, Enrique Alfaro, Ricardo Marcos-Pinto, Vladimir Milivojevic, Theodore Rokkas, Marcis Leja, Sinead Smith, Ante Tonkić, György Miklós Buzás, Michael Doulberis, Marino Venerito, Frode Lerang, Dmitry S Bordin, Vincent Lamy, Lisette G Capelle, Wojciech Marlicz, Daniela Dobru, Oleksiy Gridnyev, Ignasi Puig, Francis Mégraud, Colm O'Morain, Javier P Gisbert On behalf of the Hp-EuReg Investigators

doi: 10.1136/gutjnl-2022-328232

November 30, 2022

Hepatology
Isoformic PD-1-mediated immunosuppression underlies resistance to PD-1 blockade in hepatocellular carcinoma patients

Zhiwu Tan, Mei Sum Chiu, Xinxiang Yang, Ming Yue, Tan To Cheung, Dongyan Zhou, Yuewen Wang, Anthony Wing-Hung Chan, Chi Wing Yan, Ka Yi Kwan, Yik Chun Wong, Xin Li, Jingying Zhou, Ka Fai To, Jiye Zhu, Chung Mau Lo, Alfred Sze-Lok Cheng, Stephen Lam Chan, Li Liu, You-Qiang Song, Kwan Man, Zhiwei Chen

doi: 10.1136/gutjnl-2022-327133

November 28, 2022

Colon
Transcriptomic and immunophenotypic profiling reveals molecular and immunological hallmarks of colorectal cancer tumourigenesis

Jessica Roelands, Manon van der Ploeg, Marieke E Ijsselsteijn, Hao Dang, Jurjen J Boonstra, James C H Hardwick, Lukas J A C Hawinkels, Hans Morreau, Noel F C C de Miranda

doi: 10.1136/gutjnl-2022-327608

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