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BMJ Journals More

Online First

August 17, 2019

Inflammatory bowel disease
Imbalance of the renin–angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?

Mayur Garg, Simon G Royce, Chris Tikellis, Claire Shallue, Duygu Batu, Elena Velkoska, Louise M Burrell, Sheila K Patel, Lauren Beswick, Anvesh Jackson, Kaushali Britto, Matthew Lukies, Pavel Sluka, Hady Wardan, Yumiko Hirokawa, Chin Wee Tan, Maree Faux, Antony W Burgess, Patrick Hosking, Shaun Monagle, Merlin Thomas, Peter R Gibson, John Lubel

doi: 10.1136/gutjnl-2019-318512
Stomach
Meta-analysis of genome-wide association studies and functional assays decipher susceptibility genes for gastric cancer in Chinese populations

Caiwang Yan, Meng Zhu, Yanbing Ding, Ming Yang, Mengyun Wang, Gang Li, Chuanli Ren, Tongtong Huang, Wenjun Yang, Bangshun He, Meilin Wang, Fei Yu, Jinchen Wang, Ruoxin Zhang, Tianpei Wang, Jing Ni, Jiaping Chen, Yue Jiang, Juncheng Dai, Erbao Zhang, Hongxia Ma, Yanong Wang, Dazhi Xu, Shukui Wang, Yun Chen, Zekuan Xu, Jianwei Zhou, Guozhong Ji, Zhaoming Wang, Zhengdong Zhang, Zhibin Hu, Qingyi Wei, Hongbing Shen, Guangfu Jin

doi: 10.1136/gutjnl-2019-318760

August 14, 2019

Endoscopy News
The hidden cost of colonoscopy including cost of reprocessing and infection rate: the implications for disposable colonoscopes

Sara Larsen, Anthony Kalloo, Susan Hutfless

doi: 10.1136/gutjnl-2019-319108
PostScript
Intestinal resection rates in Crohn’s disease decline across two different epidemiological areas: a consistent observation not merely due to introduction of anti-TNFα

Evelien M J Beelen, C Janneke van der Woude, Annemarie C de Vries

doi: 10.1136/gutjnl-2019-319321
Inflammatory bowel disease
IBD prevalence in Lothian, Scotland, derived by capture–recapture methodology

Gareth-Rhys Jones, Mathew Lyons, Nikolas Plevris, Philip W Jenkinson, Cathy Bisset, Christopher Burgess, Shahida Din, James Fulforth, Paul Henderson, Gwo-Tzer Ho, Kathryn Kirkwood, Colin Noble, Alan G Shand, David C Wilson, Ian DR Arnott, Charlie W Lees

doi: 10.1136/gutjnl-2019-318936

August 13, 2019

Hepatology
Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury

Yuan Zhuang, Haifeng C Xu, Prashant V Shinde, Jens Warfsmann, Jelena Vasilevska, Balamurugan Sundaram, Kristina Behnke, Jun Huang, Jessica I Hoell, Arndt Borkhardt, Klaus Pfeffer, Mohamed S Taha, Diran Herebian, Ertan Mayatepek, Dirk Brenner, Mohammad Reza Ahmadian, Verena Keitel, Dagmar Wieczorek, Dieter Häussinger, Aleksandra A Pandyra, Karl S Lang, Philipp A Lang

doi: 10.1136/gutjnl-2019-318215
GI cancer
Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in oesophageal adenocarcinoma

Li Chen, Moli Huang, Jasmine Plummer, Jian Pan, Yan Yi Jiang, Qian Yang, Tiago Chedraoui Silva, Nicole Gull, Stephanie Chen, Ling Wen Ding, Omer An, Henry Yang, Yulan Cheng, Jonathan W Said, Ngan Doan, Winand NM Dinjens, Kevin M Waters, Richard Tuli, Simon A Gayther, Samuel J Klempner, Benjamin P Berman, Stephen J Meltzer, De-Chen Lin, H Phillip Koeffler

doi: 10.1136/gutjnl-2019-318325
Oesophagus
Phase III, randomised, double-blind, multicentre study to evaluate the efficacy and safety of vonoprazan compared with lansoprazole in Asian patients with erosive oesophagitis

Yinglian Xiao, Shutian Zhang, Ning Dai, Guijun Fei, Khean-Lee Goh, Hoon Jai Chun, Bor-Shyang Sheu, Chui Fung Chong, Nobuo Funao, Wen Zhou, Minhu Chen

doi: 10.1136/gutjnl-2019-318365

August 10, 2019

Hepatology
Novel strategy for oral peptide delivery in incretin-based diabetes treatment

Yining Xu, Matthias Van Hul, Francesco Suriano, Véronique Préat, Patrice D Cani, Ana Beloqui

doi: 10.1136/gutjnl-2019-319146

August 09, 2019

Oesophagus
Immune activation by DNA damage predicts response to chemotherapy and survival in oesophageal adenocarcinoma

Richard C Turkington, Laura A Knight, Jaine K Blayney, Maria Secrier, Rosalie Douglas, Eileen E Parkes, Eilis K Sutton, Leanne Stevenson, Damian McManus, Sophia Halliday, Andrena M McCavigan, Gemma E Logan, Steven M Walker, Christopher J Steele, Juliane Perner, Jan Bornschein, Shona MacRae, Ahmad Miremadi, Eamon McCarron, Stephen McQuaid, Kenneth Arthur, Jacqueline A James, Martin M Eatock, Robert O’Neill, Fergus Noble, Timothy J Underwood, D Paul Harkin, Manuel Salto-Tellez, Rebecca C Fitzgerald, Richard D Kennedy on behalf of the Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group

doi: 10.1136/gutjnl-2018-317624
Endoscopy News
Case of early Barrett cancer following peroral endoscopic myotomy

Yervant Ichkhanian, Petros Benias, Mouen A Khashab

doi: 10.1136/gutjnl-2019-318950

August 08, 2019

PostScript
Management of acute lower gastrointestinal bleeding: evidence based medicine? Authors’ reply

Kathryn Oakland, Jonathan Hoare

doi: 10.1136/gutjnl-2019-319525

August 07, 2019

Commentary
New warning signs on the road: 5-hydroxymethylcytosine-based liquid biopsy for the early detection of hepatocellular carcinoma

Maria Arechederra

doi: 10.1136/gutjnl-2019-319339

August 05, 2019

PostScript
Response to the recently published guidelines on lower gastrointestinal bleeding

Samuel Snelling, Rania Ghaffar, Stephen Thomas Ward

doi: 10.1136/gutjnl-2019-319515
PostScript
Mortality rate after pneumatic dilatation for achalasia

Froukje B van Hoeij, Albert J Bredenoord

doi: 10.1136/gutjnl-2019-319513

August 02, 2019

Commentary
Getting insights into hepatocellular carcinoma tumour heterogeneity by multiomics dissection

Pablo Sarobe, Fernando Corrales

doi: 10.1136/gutjnl-2019-319410
PostScript
First known case of paediatric inflammatory bowel disease in a western lowland gorilla may be linked to a familial mutation in the MEFV gene

Britt-Sabina Petersen, Bernd Bokemeyer, Christian Wenker, Stefan Hoby, Katrin Baumgartner, Hermann Will, Marc P Hoeppner, Stefan Schreiber, Ingo Mecklenburg, Andre Franke

doi: 10.1136/gutjnl-2019-319051
Oesophagus
How to select patients for antireflux surgery? The ICARUS guidelines (international consensus regarding preoperative examinations and clinical characteristics assessment to select adult patients for antireflux surgery)

Ans Pauwels, Veerle Boecxstaens, Christopher N Andrews, Stephen E Attwood, Richard Berrisford, Raf Bisschops, Guy E Boeckxstaens, Serhat Bor, Albert J Bredenoord, Michele Cicala, Maura Corsetti, Fernando Fornari, Chandra Prakash Gyawali, Jan Hatlebakk, Scott B Johnson, Toni Lerut, Lars Lundell, Sandro Mattioli, Hiroto Miwa, Philippe Nafteux, Taher Omari, John Pandolfino, Roberto Penagini, Thomas W Rice, Philip Roelandt, Nathalie Rommel, Vincenzo Savarino, Daniel Sifrim, Hidekazu Suzuki, Radu Tutuian, Tim Vanuytsel, Marcelo F Vela, David I Watson, Frank Zerbib, Jan Tack

doi: 10.1136/gutjnl-2019-318260
Hepatology
Adeno-associated virus in the liver: natural history and consequences in tumour development

Tiziana La Bella, Sandrine Imbeaud, Camille Peneau, Iadh Mami, Shalini Datta, Quentin Bayard, Stefano Caruso, Theo Z Hirsch, Julien Calderaro, Guillaume Morcrette, Catherine Guettier, Valerie Paradis, Giuliana Amaddeo, Alexis Laurent, Laurent Possenti, Laurence Chiche, Paulette Bioulac-Sage, Jean-Frederic Blanc, Eric Letouze, Jean-Charles Nault, Jessica Zucman-Rossi

doi: 10.1136/gutjnl-2019-318281
Endoscopy news
Deep-learning based detection of gastric precancerous conditions

Pedro Guimarães, Andreas Keller, Tobias Fehlmann, Frank Lammert, Markus Casper

doi: 10.1136/gutjnl-2019-319347
Editor’s quiz: GI snapshot
Jejunal perforation and central retinal vein occlusion in a 55-year-old European man

Amanda Louise Thomas, Luke Summers, James R Goodhand, Sarah Saunders

doi: 10.1136/gutjnl-2019-318342

July 31, 2019

Guidelines
British Society of Gastroenterology guidelines for oesophageal manometry and oesophageal reflux monitoring

Nigel J Trudgill, Daniel Sifrim, Rami Sweis, Mark Fullard, Kumar Basu, Mimi McCord, Michael Booth, John Hayman, Guy Boeckxstaens, Brian T Johnston, Nicola Ager, John De Caestecker

doi: 10.1136/gutjnl-2018-318115
Inflammatory bowel disease
ZEB1 promotes inflammation and progression towards inflammation-driven carcinoma through repression of the DNA repair glycosylase MPG in epithelial cells

Oriol de Barrios, Lidia Sanchez-Moral, Marlies Cortés, Chiara Ninfali, Nuria Profitós-Pelejà, MC Martínez-Campanario, Laura Siles, Rosa del Campo, María Jesús Fernández-Aceñero, Douglas S Darling, Antoni Castells, Joan Maurel, Azucena Salas, Douglas C Dean, Antonio Postigo

doi: 10.1136/gutjnl-2018-317294
PostScript
Comparison of the incidence of colorectal cancer in young adults between the USA and Europe

Ting Wei, Peng Luo, Xiaoli Zhang, Weiliang Zhu, Jian Zhang

doi: 10.1136/gutjnl-2019-319391
Hepatology
Epidemiology of chronic liver diseases in the USA in the past three decades

Zobair M Younossi, Maria Stepanova, Youssef Younossi, Pegah Golabi, Alita Mishra, Nila Rafiq, Linda Henry

doi: 10.1136/gutjnl-2019-318813

July 30, 2019

Editor's quiz: GI snapshot
Seeing red after a prostate procedure

Maximillian Hugo Brodermann, Mark A Samaan, Shameer Mehta, Sara McCartney

doi: 10.1136/gutjnl-2019-319071

July 29, 2019

Editor's quiz: GI snapshot
Unusual cystic lesion adjacent to the stomach

John J McGoran, Joseph H Mullineux, Christopher D Sutton, Sudarshan R Kadri

doi: 10.1136/gutjnl-2019-318823
Hepatology
Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma

Jiabin Cai, Lei Chen, Zhou Zhang, Xinyu Zhang, Xingyu Lu, Weiwei Liu, Guoming Shi, Yang Ge, Pingting Gao, Yuan Yang, Aiwu Ke, Linlin Xiao, Ruizhao Dong, Yanjing Zhu, Xuan Yang, Jiefei Wang, Tongyu Zhu, Deping Yang, Xiaowu Huang, Chengjun Sui, Shuangjian Qiu, Feng Shen, Huichuan Sun, Weiping Zhou, Jian Zhou, Ji Nie, Chang Zeng, Emily Kunce Stroup, Xu Zhang, Brian C-H Chiu, Wan Yee Lau, Chuan He, Hongyang Wang, Wei Zhang, Jia Fan

doi: 10.1136/gutjnl-2019-318882
PostScript
Cautious view on the link between yoghurt consumption and risk of colorectal cancer

Jiaoyan Ren, Maojin Yao

doi: 10.1136/gutjnl-2019-319430

July 24, 2019

PostScript
Impaired cell surface expression and digestive function of sucrase-isomaltase gene variants are associated with reduced efficacy of low FODMAPs diet in patients with IBS-D

Diab M Husein, Hassan Y Naim

doi: 10.1136/gutjnl-2019-319411

July 22, 2019

Gastroduodenal
Endoscopic duodenal mucosal resurfacing for the treatment of type 2 diabetes mellitus: one year results from the first international, open-label, prospective, multicentre study

Annieke C G van Baar, Frits Holleman, Laurent Crenier, Rehan Haidry, Cormac Magee, David Hopkins, Leonardo Rodriguez Grunert, Manoel Galvao Neto, Paulina Vignolo, Bu’Hussain Hayee, Ann Mertens, Raf Bisschops, Jan Tijssen, Max Nieuwdorp, Caterina Guidone, Guido Costamagna, Jacques Devière, Jacques J G H M Bergman

doi: 10.1136/gutjnl-2019-318349

July 17, 2019

PostScript
Management of acute lower GI bleeding: evidence-based medicine?

John S Leeds, Anthoor Jayaprakash, David S Sanders

doi: 10.1136/gutjnl-2019-319428

July 16, 2019

PostScript
RE: Early application of haemostatic powder added to standard management for oesophagogastric variceal bleeding: a randomised trial

Michael Johnston, Charlotte Cook, Ryan Malcolm Buchanan

doi: 10.1136/gutjnl-2019-319272

July 15, 2019

Inflammatory bowel disease
Introduction of anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases: a population-based interrupted time series study

Sanjay K Murthy, Jahanara Begum, Eric I Benchimol, Charles N Bernstein, Gilaad G Kaplan, Jeffrey D McCurdy, Harminder Singh, Laura Targownik, Monica Taljaard

doi: 10.1136/gutjnl-2019-318440

July 13, 2019

PostScript
Role of portal venous platelet activation in patients with decompensated cirrhosis and TIPS

Alexander Queck, Roberto Carnevale, Frank Erhard Uschner, Robert Schierwagen, Sabine Klein, Christian Jansen, Carsten Meyer, Michael Praktiknjo, Daniel Thomas, Christian Strassburg, Stefan Zeuzem, Francesco Violi, Jonel Trebicka

doi: 10.1136/gutjnl-2019-319044

July 12, 2019

Recent advances in basic science
Liver organoids: from basic research to therapeutic applications

Nicole Prior, Patricia Inacio, Meritxell Huch

doi: 10.1136/gutjnl-2019-319256
Recent advances in basic science
miRNAs and NAFLD: from pathophysiology to therapy

Monika Gjorgjieva, Cyril Sobolewski, Dobrochna Dolicka, Marta Correia de Sousa, Michelangelo Foti

doi: 10.1136/gutjnl-2018-318146

July 11, 2019

Pancreas
Loss of Setd2 promotes Kras-induced acinar-to-ductal metaplasia and epithelia–mesenchymal transition during pancreatic carcinogenesis

Ningning Niu, Ping Lu, Yanlin Yang, Ruizhe He, Li Zhang, Juanjuan Shi, Jinghua Wu, Minwei Yang, Zhi-Gang Zhang, Lei-Wei Wang, Wei-Qiang Gao, Aida Habtezion, Gary Guishan Xiao, Yongwei Sun, Li Li, Jing Xue

doi: 10.1136/gutjnl-2019-318362
PostScript
Authors response: giant oversights in the human gut virome

Tao Zuo, Siew C Ng

doi: 10.1136/gutjnl-2019-319357

July 08, 2019

Inflammatory bowel disease
Tight control for Crohn’s disease with adalimumab-based treatment is cost-effective: an economic assessment of the CALM trial

Remo Panaccione, Jean-Frederic Colombel, Simon P L Travis, Peter Bossuyt, Filip Baert, Tomáš Vaňásek, Ahmet Danalıoğlu, Gottfried Novacek, Alessandro Armuzzi, Walter Reinisch, Scott Johnson, Marric Buessing, Ezequiel Neimark, Joel Petersson, Wan-Ju Lee, Geert R D’Haens

doi: 10.1136/gutjnl-2019-318256

July 05, 2019

Recent advances in basic science
JAK selectivity for inflammatory bowel disease treatment: does it clinically matter?

Silvio Danese, Marjorie Argollo, Catherine Le Berre, Laurent Peyrin-Biroulet

doi: 10.1136/gutjnl-2019-318448

July 03, 2019

GI cancer
High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity

Natasja L de Vries, Vincent van Unen, Marieke E Ijsselsteijn, Tamim Abdelaal, Ruud van der Breggen, Arantza Farina Sarasqueta, Ahmed Mahfouz, Koen C M J Peeters, Thomas Höllt, Boudewijn P F Lelieveldt, Frits Koning, Noel F C C de Miranda

doi: 10.1136/gutjnl-2019-318672
Commentary
Hepatocellular carcinomas: evolution to sorafenib resistance through hepatic leukaemia factor

Orlando Musso, Naiara Beraza

doi: 10.1136/gutjnl-2019-318999

June 27, 2019

Editor’s quiz: GI snapshot
Seventy-five-year-old man with unexplained weight loss and alopecia

Elmer Hoekstra, Jaap van der Laan, Michael van der Voorn

doi: 10.1136/gutjnl-2019-319013

June 26, 2019

Commentary
Epigenetic modulation of immunity: towards new therapeutic avenues in hepatocellular carcinoma?

Angelique Gougelet

doi: 10.1136/gutjnl-2019-319084
Gut microbiota
Alterations of the bile microbiome in primary sclerosing cholangitis

Timur Liwinski, Roman Zenouzi, Clara John, Hanno Ehlken, Malte C Rühlemann, Corinna Bang, Stefan Groth, Wolfgang Lieb, Marcus Kantowski, Nils Andersen, Guido Schachschal, Tom H Karlsen, Johannes R Hov, Thomas Rösch, Ansgar W Lohse, Joerg Heeren, Andre Franke, Christoph Schramm

doi: 10.1136/gutjnl-2019-318416

June 22, 2019

GI bleeding
Prevention of recurrent idiopathic gastroduodenal ulcer bleeding: a double-blind, randomised trial

Grace L H Wong, Louis H S Lau, Jessica Y L Ching, Yee-Kit Tse, Rachel H Y Ling, Vincent W S Wong, Philip W Y Chiu, James Y W Lau, Francis K L Chan

doi: 10.1136/gutjnl-2019-318715
Gut microbiota
Alterations of gut microbiome in autoimmune hepatitis

Yiran Wei, Yanmei Li, Li Yan, Chunyan Sun, Qi Miao, Qixia Wang, Xiao Xiao, Min Lian, Bo Li, Yong Chen, Jun Zhang, You Li, Bingyuan Huang, Yikang Li, Qin Cao, Zhuping Fan, Xiaoyu Chen, Jing-Yuan Fang, Merrill Eric Gershwin, Ruqi Tang, Xiong Ma

doi: 10.1136/gutjnl-2018-317836

June 21, 2019

GI cancer
Early evaluation using a radiomic signature of unresectable hepatic metastases to predict outcome in patients with colorectal cancer treated with FOLFIRI and bevacizumab

Anthony Dohan, Benoit Gallix, Boris Guiu, Karine Le Malicot, Caroline Reinhold, Philippe Soyer, Jaafar Bennouna, Francois Ghiringhelli, Emilie Barbier, Valérie Boige, Julien Taieb, Olivier Bouché, Eric François, Jean-Marc Phelip, Christian Borel, Roger Faroux, Jean-Francois Seitz, Stéphane Jacquot, Meher Ben Abdelghani, Faiza Khemissa-Akouz, Dominique Genet, Jean Louis Jouve, Yves Rinaldi, Françoise Desseigne, Patrick Texereau, Etienne Suc, Come Lepage, Thomas Aparicio, Christine Hoeffel for the PRODIGE 9 Investigators and PRODIGE 20 Investigators

doi: 10.1136/gutjnl-2018-316407
Hepatology
Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomas

Qi Zhang, Yu Lou, Jiaqi Yang, Junli Wang, Jie Feng, Yali Zhao, Lin Wang, Xing Huang, Qihan Fu, Mao Ye, Xiaozhen Zhang, Yiwen Chen, Ce Ma, Hongbin Ge, Jianing Wang, Jiangchao Wu, Tao Wei, Qi Chen, Junqing Wu, Chengxuan Yu, Yanyu Xiao, Xinhua Feng, Guoji Guo, Tingbo Liang, Xueli Bai

doi: 10.1136/gutjnl-2019-318912

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