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BMJ Journals More

Online First

July 17, 2019

PostScript
Management of acute lower GI bleeding: evidence-based medicine?

John S Leeds, Anthoor Jayaprakash, David S Sanders

doi: 10.1136/gutjnl-2019-319428
Hepatology
Expression of the type 3 InsP₃ receptor is a final common event in the development of hepatocellular carcinoma

Mateus T Guerra, Rodrigo M Florentino, Andressa Franca, Antonio C Lima Filho, Marcone L dos Santos, Roberta C Fonseca, Fernanda O Lemos, Matheus C Fonseca, Emma Kruglov, Albert Mennone, Basile Njei, Joanna Gibson, Fulan Guan, Yung-Chi Cheng, Meenakshisundaram Ananthanarayanam, Jianlei Gu, Jianping Jiang, Hongyu Zhao, Cristiano X Lima, Paula T Vidigal, Andre G Oliveira, Michael H Nathanson, Maria Fatima Leite

doi: 10.1136/gutjnl-2018-317811

July 16, 2019

PostScript
RE: Early application of haemostatic powder added to standard management for oesophagogastric variceal bleeding: a randomised trial

Michael Johnston, Charlotte Cook, Ryan Malcolm Buchanan

doi: 10.1136/gutjnl-2019-319272

July 15, 2019

Inflammatory bowel disease
Introduction of anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases: a population-based interrupted time series study

Sanjay K Murthy, Jahanara Begum, Eric I Benchimol, Charles N Bernstein, Gilaad G Kaplan, Jeffrey D McCurdy, Harminder Singh, Laura Targownik, Monica Taljaard

doi: 10.1136/gutjnl-2019-318440

July 13, 2019

PostScript
Role of portal venous platelet activation in patients with decompensated cirrhosis and TIPS

Alexander Queck, Roberto Carnevale, Frank Erhard Uschner, Robert Schierwagen, Sabine Klein, Christian Jansen, Carsten Meyer, Michael Praktiknjo, Daniel Thomas, Christian Strassburg, Stefan Zeuzem, Francesco Violi, Jonel Trebicka

doi: 10.1136/gutjnl-2019-319044

July 12, 2019

PostScript
Meta-analysis of the accuracy of Liver Imaging Reporting and Data System category 4 or 5 for diagnosing hepatocellular carcinoma

Dong Hwan Kim, Sang Hyun Choi, Seong Ho Park, Kyung Won Kim, Jae Ho Byun, So Yeon Kim, Seung Soo Lee, Yong Moon Shin, Hyung Jin Won, Pyo-Nyun Kim

doi: 10.1136/gutjnl-2019-318555
Recent advances in basic science
miRNAs and NAFLD: from pathophysiology to therapy

Monika Gjorgjieva, Cyril Sobolewski, Dobrochna Dolicka, Marta Correia de Sousa, Michelangelo Foti

doi: 10.1136/gutjnl-2018-318146
Recent advances in basic science
Liver organoids: from basic research to therapeutic applications

Nicole Prior, Patricia Inacio, Meritxell Huch

doi: 10.1136/gutjnl-2019-319256

July 11, 2019

Pancreas
Loss of Setd2 promotes Kras-induced acinar-to-ductal metaplasia and epithelia–mesenchymal transition during pancreatic carcinogenesis

Ningning Niu, Ping Lu, Yanlin Yang, Ruizhe He, Li Zhang, Juanjuan Shi, Jinghua Wu, Minwei Yang, Zhi-Gang Zhang, Lei-Wei Wang, Wei-Qiang Gao, Aida Habtezion, Gary Guishan Xiao, Yongwei Sun, Li Li, Jing Xue

doi: 10.1136/gutjnl-2019-318362
PostScript
Authors response: giant oversights in the human gut virome

Tao Zuo, Siew C Ng

doi: 10.1136/gutjnl-2019-319357
Inflammatory bowel disease
IBD prevalence in Lothian, Scotland, derived by capture–recapture methodology

Gareth-Rhys Jones, Mathew Lyons, Nikolas Plevris, Philip W Jenkinson, Cathy Bisset, Christopher Burgess, Shahida Din, James Fulforth, Paul Henderson, Gwo-Tzer Ho, Kathryn Kirkwood, Colin Noble, Alan G Shand, David C Wilson, Ian DR Arnott, Charlie W Lees

doi: 10.1136/gutjnl-2019-318936

July 08, 2019

Inflammatory bowel disease
Tight control for Crohn’s disease with adalimumab-based treatment is cost-effective: an economic assessment of the CALM trial

Remo Panaccione, Jean-Frederic Colombel, Simon P L Travis, Peter Bossuyt, Filip Baert, Tomáš Vaňásek, Ahmet Danalıoğlu, Gottfried Novacek, Alessandro Armuzzi, Walter Reinisch, Scott Johnson, Marric Buessing, Ezequiel Neimark, Joel Petersson, Wan-Ju Lee, Geert R D’Haens

doi: 10.1136/gutjnl-2019-318256

July 05, 2019

Guidelines
British Society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma

Matthew Banks, David Graham, Marnix Jansen, Takuji Gotoda, Sergio Coda, Massimiliano di Pietro, Noriya Uedo, Pradeep Bhandari, D Mark Pritchard, Ernst J Kuipers, Manuel Rodriguez-Justo, Marco R Novelli, Krish Ragunath, Neil Shepherd, Mario Dinis-Ribeiro

doi: 10.1136/gutjnl-2018-318126
Recent advances in basic science
JAK selectivity for inflammatory bowel disease treatment: does it clinically matter?

Silvio Danese, Marjorie Argollo, Catherine Le Berre, Laurent Peyrin-Biroulet

doi: 10.1136/gutjnl-2019-318448

July 03, 2019

Leading article
IBD BioResource: an open-access platform of 25 000 patients to accelerate research in Crohn’s and Colitis

Miles Parkes On behalf of the IBD BioResource Investigators

doi: 10.1136/gutjnl-2019-318835
GI cancer
High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity

Natasja L de Vries, Vincent van Unen, Marieke E Ijsselsteijn, Tamim Abdelaal, Ruud van der Breggen, Arantza Farina Sarasqueta, Ahmed Mahfouz, Koen C M J Peeters, Thomas Höllt, Boudewijn P F Lelieveldt, Frits Koning, Noel F C C de Miranda

doi: 10.1136/gutjnl-2019-318672
Commentary
Hepatocellular carcinomas: evolution to sorafenib resistance through hepatic leukaemia factor

Orlando Musso, Naiara Beraza

doi: 10.1136/gutjnl-2019-318999

June 27, 2019

Editor’s quiz: GI snapshot
Seventy-five-year-old man with unexplained weight loss and alopecia

Elmer Hoekstra, Jaap van der Laan, Michael van der Voorn

doi: 10.1136/gutjnl-2019-319013

June 26, 2019

Commentary
Epigenetic modulation of immunity: towards new therapeutic avenues in hepatocellular carcinoma?

Angelique Gougelet

doi: 10.1136/gutjnl-2019-319084
Gut microbiota
Alterations of the bile microbiome in primary sclerosing cholangitis

Timur Liwinski, Roman Zenouzi, Clara John, Hanno Ehlken, Malte C Rühlemann, Corinna Bang, Stefan Groth, Wolfgang Lieb, Marcus Kantowski, Nils Andersen, Guido Schachschal, Tom H Karlsen, Johannes R Hov, Thomas Rösch, Ansgar W Lohse, Joerg Heeren, Andre Franke, Christoph Schramm

doi: 10.1136/gutjnl-2019-318416

June 25, 2019

Recent advances in clinical practice
Role of brain imaging in disorders of brain–gut interaction: a Rome Working Team Report

Emeran A Mayer, Jennifer Labus, Qasim Aziz, Irene Tracey, Lisa Kilpatrick, Sigrid Elsenbruch, Petra Schweinhardt, Lukas Van Oudenhove, David Borsook

doi: 10.1136/gutjnl-2019-318308

June 22, 2019

GI bleeding
Prevention of recurrent idiopathic gastroduodenal ulcer bleeding: a double-blind, randomised trial

Grace L H Wong, Louis H S Lau, Jessica Y L Ching, Yee-Kit Tse, Rachel H Y Ling, Vincent W S Wong, Philip W Y Chiu, James Y W Lau, Francis K L Chan

doi: 10.1136/gutjnl-2019-318715
Gut microbiota
Alterations of gut microbiome in autoimmune hepatitis

Yiran Wei, Yanmei Li, Li Yan, Chunyan Sun, Qi Miao, Qixia Wang, Xiao Xiao, Min Lian, Bo Li, Yong Chen, Jun Zhang, You Li, Bingyuan Huang, Yikang Li, Qin Cao, Zhuping Fan, Xiaoyu Chen, Jing-Yuan Fang, Merrill Eric Gershwin, Ruqi Tang, Xiong Ma

doi: 10.1136/gutjnl-2018-317836

June 21, 2019

GI cancer
Early evaluation using a radiomic signature of unresectable hepatic metastases to predict outcome in patients with colorectal cancer treated with FOLFIRI and bevacizumab

Anthony Dohan, Benoit Gallix, Boris Guiu, Karine Le Malicot, Caroline Reinhold, Philippe Soyer, Jaafar Bennouna, Francois Ghiringhelli, Emilie Barbier, Valérie Boige, Julien Taieb, Olivier Bouché, Eric François, Jean-Marc Phelip, Christian Borel, Roger Faroux, Jean-Francois Seitz, Stéphane Jacquot, Meher Ben Abdelghani, Faiza Khemissa-Akouz, Dominique Genet, Jean Louis Jouve, Yves Rinaldi, Françoise Desseigne, Patrick Texereau, Etienne Suc, Come Lepage, Thomas Aparicio, Christine Hoeffel for the PRODIGE 9 Investigators and PRODIGE 20 Investigators

doi: 10.1136/gutjnl-2018-316407
PostScript
First known case of paediatric inflammatory bowel disease in a western lowland gorilla may be linked to a familial mutation in the MEFV gene

Britt-Sabina Petersen, Bernd Bokemeyer, Christian Wenker, Stefan Hoby, Katrin Baumgartner, Hermann Will, Marc P Hoeppner, Stefan Schreiber, Ingo Mecklenburg, Andre Franke

doi: 10.1136/gutjnl-2019-319051
Hepatology
Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomas

Qi Zhang, Yu Lou, Jiaqi Yang, Junli Wang, Jie Feng, Yali Zhao, Lin Wang, Xing Huang, Qihan Fu, Mao Ye, Xiaozhen Zhang, Yiwen Chen, Ce Ma, Hongbin Ge, Jianing Wang, Jiangchao Wu, Tao Wei, Qi Chen, Junqing Wu, Chengxuan Yu, Yanyu Xiao, Xinhua Feng, Guoji Guo, Tingbo Liang, Xueli Bai

doi: 10.1136/gutjnl-2019-318912

June 20, 2019

PostScript
Tracing the accumulation of in vivo human oral microbiota elucidates microbial community dynamics at the gateway to the GI tract

Jinfeng Wang, Zhen Jia, Bing Zhang, Lei Peng, Fangqing Zhao

doi: 10.1136/gutjnl-2019-318977

June 19, 2019

PostScript
Absence of hepatitis E virus RNA in semen samples of infertile male in China

Lin Wang, Zhe Zhang, Jingyi Shu, Haitao Zhang, Yuzhuo Yang, Zhaochao Liang, Qiyu He, Weijin Huang, Youchun Wang, Hui Zhuang, Hui Jiang, Ling Wang

doi: 10.1136/gutjnl-2019-319234

June 17, 2019

PostScript
Yogurt consumption and risk of conventional and serrated precursors of colorectal cancer

Xiaobin Zheng, Kana Wu, Mingyang Song, Shuji Ogino, Charles S Fuchs, Andrew T Chan, Edward L Giovannucci, Yin Cao, Xuehong Zhang

doi: 10.1136/gutjnl-2019-318374

June 15, 2019

PostScript
Trust is good, control is better: technical considerations in blood microbiome analysis

Robert Schierwagen, Camila Alvarez-Silva, Florence Servant, Jonel Trebicka, Benjamin Lelouvier, Manimozhiyan Arumugam

doi: 10.1136/gutjnl-2019-319123
PostScript
Towards standardisation of naming novel prokaryotic taxa in the age of high-throughput microbiology

Falk Hildebrand, Mark J Pallen, Peer Bork

doi: 10.1136/gutjnl-2019-319045

June 14, 2019

Pancreas
Morphological classification of pancreatic ductal adenocarcinoma that predicts molecular subtypes and correlates with clinical outcome

Sangeetha N Kalimuthu, Gavin W Wilson, Robert C Grant, Matthew Seto, Grainne O’Kane, Rajkumar Vajpeyi, Faiyaz Notta, Steven Gallinger, Runjan Chetty

doi: 10.1136/gutjnl-2019-318217
PostScript
β6 integrinosis: a new lethal autosomal recessive ITGB6 disorder leading to impaired conformational transitions of the α_Vβ6 integrin receptor

Patrick Weil, Rhea van den Bruck, Thomas Ziegenhals, Stefan Juranek, Daniel Goedde, Valerie Orth, Stefan Wirth, Andreas C Jenke, Jan Postberg

doi: 10.1136/gutjnl-2019-319015
PostScript
GI infections are associated with an increased risk of Parkinson’s disease

Michael Nerius, Gabriele Doblhammer, Gültekin Tamgüney

doi: 10.1136/gutjnl-2019-318822

June 12, 2019

Nutrition
Milk polar lipids reduce lipid cardiovascular risk factors in overweight postmenopausal women: towards a gut sphingomyelin-cholesterol interplay

Cécile Vors, Laurie Joumard-Cubizolles, Manon Lecomte, Emmanuel Combe, Lemlih Ouchchane, Jocelyne Drai, Ketsia Raynal, Florent Joffre, Laure Meiller, Mélanie Le Barz, Patrice Gaborit, Aurélie Caille, Monique Sothier, Carla Domingues-Faria, Adeline Blot, Aurélie Wauquier, Emilie Blond, Valérie Sauvinet, Geneviève Gésan-Guiziou, Jean-Pierre Bodin, Philippe Moulin, David Cheillan, Hubert Vidal, Béatrice Morio, Eddy Cotte, Françoise Morel-Laporte, Martine Laville, Annick Bernalier-Donadille, Stéphanie Lambert-Porcheron, Corinne Malpuech-Brugère, Marie-Caroline Michalski

doi: 10.1136/gutjnl-2018-318155

June 11, 2019

PostScript
Giant oversights in the human gut virome

Thomas D S Sutton, Adam G Clooney, Colin Hill

doi: 10.1136/gutjnl-2019-319067
Hepatology
APOBEC3B interaction with PRC2 modulates microenvironment to promote HCC progression

Duowei Wang, Xianjing Li, Jiani Li, Yuan Lu, Sen Zhao, Xinying Tang, Xin Chen, Jiaying Li, Yan Zheng, Shuran Li, Rui Sun, Ming Yan, Decai Yu, Guangwen Cao, Yong Yang

doi: 10.1136/gutjnl-2018-317601
PostScript
Secondary prevention of gastric cancer: merging the endoscopic atrophic border with OLGA staging

Massimo Rugge, Diana Sacchi, David Y Graham, Robert M Genta

doi: 10.1136/gutjnl-2019-319107
GI cancer
Personalised surveillance for serrated polyposis syndrome: results from a prospective 5-year international cohort study

Arne GC Bleijenberg, Joep EG IJspeert, Yasmijn J van Herwaarden, Sabela Carballal, María Pellisé, Gerhard Jung, Tanya M Bisseling, Iris D Nagetaal, Monique E van Leerdam, Niels van Lelyveld, Xavier Bessa, Francisco Rodríguez-Moranta, Barbara Bastiaansen, Willemijn de Klaver, Liseth Rivero, Manon CW Spaander, Jan Jacob Koornstra, Luis Bujanda, Francesc Balaguer, Evelien Dekker

doi: 10.1136/gutjnl-2018-318134
GI cancer
Increasing incidence of colorectal cancer in young adults in Europe over the last 25 years

Fanny ER Vuik, Stella AV Nieuwenburg, Marc Bardou, Iris Lansdorp-Vogelaar, Mário Dinis-Ribeiro, Maria J Bento, Vesna Zadnik, María Pellisé, Laura Esteban, Michal F Kaminski, Stepan Suchanek, Ondřej Ngo, Ondřej Májek, Marcis Leja, Ernst J Kuipers, Manon CW Spaander

doi: 10.1136/gutjnl-2018-317592

June 06, 2019

Upper GI cancer
Multiplex profiling of peritoneal metastases from gastric adenocarcinoma identified novel targets and molecular subtypes that predict treatment response

Ruiping Wang, Shumei Song, Kazuto Harada, Fatemeh Ghazanfari Amlashi, Brian Badgwell, Melissa Pool Pizzi, Yan Xu, Wei Zhao, Xiaochuan Dong, Jiangkang Jin, Ying Wang, Ailing Scott, Lang Ma, Longfei Huo, Diego Vicente, Mariela Blum Murphy, Namita Shanbhag, Ghia Tatlonghari, Irene Thomas, Jane Rogers, Makoto Kobayashi, Jody Vykoukal, Jeannelyn Santiano Estrella, Sinchita Roy-Chowdhuri, Guangchun Han, Shaojun Zhang, Xizeng Mao, Xingzhi Song, Jianhua Zhang, Jian Gu, Randy L Johnson, George Adrian Calin, Guang Peng, Ju-Seog Lee, Samir M Hanash, Andrew Futreal, Zhenning Wang, Linghua Wang, Jaffer A Ajani

doi: 10.1136/gutjnl-2018-318070
Hepatology
Glial cell line-derived neurotrophic factor (GDNF) mediates hepatic stellate cell activation via ALK5/Smad signalling

Le Tao, Wenting Ma, Liu Wu, Mingyi Xu, Yanqin Yang, Wei Zhang, Wenjun Sha, Hongshan Li, Jianrong Xu, Rilu Feng, Dongying Xue, Jie Zhang, Steven Dooley, Ekihiro Seki, Ping Liu, Cheng Liu

doi: 10.1136/gutjnl-2018-317872

June 05, 2019

Inflammatory bowel disease
Modulation of cytokine patterns and microbiome during pregnancy in IBD

Janine van der Giessen, Dana Binyamin, Anna Belogolovski, Sigal Frishman, Kinneret Tenenbaum-Gavish, Eran Hadar, Yoram Louzoun, Maikel Petrus Peppelenbosch, Christien Janneke van der Woude, Omry Koren, Gwenny Manel Fuhler

doi: 10.1136/gutjnl-2019-318263

June 01, 2019

PostScript
RSPO2 abnormal transcripts result from read-through in liver tumours with high ß-catenin activation and CTNNB1 mutations

Quentin Bayard, Jean-Charles Nault, Jessica Zucman-Rossi

doi: 10.1136/gutjnl-2019-319089
Pancreas
Kras and Lkb1 mutations synergistically induce intraductal papillary mucinous neoplasm derived from pancreatic duct cells

Louis Collet, Elsa Ghurburrun, Nora Meyers, Mohamad Assi, Boris Pirlot, Isabelle A Leclercq, Anne Couvelard, Mina Komuta, Jérôme Cros, Pieter Demetter, Frédéric P Lemaigre, Ivan Borbath, Patrick Jacquemin

doi: 10.1136/gutjnl-2018-318059
Editor’s quiz: GI snapshot
Recurrent bacteraemia following variceal haemorrhage

Rooshi Nathwani, Benjamin H Mullish, David Kockerling, Nikil Rajani, Ameet Dhar

doi: 10.1136/gutjnl-2019-318917

May 30, 2019

Gut microbiota
Donor metabolic characteristics drive effects of faecal microbiota transplantation on recipient insulin sensitivity, energy expenditure and intestinal transit time

Pieter de Groot, Torsten Scheithauer, Guido J Bakker, Andrei Prodan, Evgeni Levin, Muhammad Tanweer Khan, Hilde Herrema, Mariette Ackermans, Mireille J M Serlie, Maurits de Brauw, Johannes H M Levels, Amber Sales, Victor E Gerdes, Marcus Ståhlman, Alinda W M Schimmel, Geesje Dallinga-Thie, Jacques JGHM Bergman, Frits Holleman, Joost B L Hoekstra, Albert Groen, Fredrik Bäckhed, Max Nieuwdorp

doi: 10.1136/gutjnl-2019-318320

May 29, 2019

PostScript
Heterozygous Spink1 c.194+2T>C mutant mice spontaneously develop chronic pancreatitis

Chang Sun, Muyun Liu, Wei An, Xiaotong Mao, Hui Jiang, WenBin Zou, Hao Wu, Zhuan Liao, Zhaoshen Li

doi: 10.1136/gutjnl-2019-318790
Inflammatory bowel disease
Prominence of ileal mucosa-associated microbiota to predict postoperative endoscopic recurrence in Crohn’s disease

Harry Sokol, Loic Brot, Carmen Stefanescu, Claire Auzolle, Nicolas Barnich, Anthony Buisson, Mathurin Fumery, Benjamin Pariente, Lionel Le Bourhis, Xavier Treton, Stéphane Nancey, Matthieu Allez, Philippe Seksik REMIND Study Group Investigators

doi: 10.1136/gutjnl-2019-318719

May 24, 2019

Recent advances in basic science
Immune cell trafficking and retention in inflammatory bowel disease: mechanistic insights and therapeutic advances

Sebastian Zundler, Emily Becker, Lisa Lou Schulze, Markus F Neurath

doi: 10.1136/gutjnl-2018-317977

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