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BMJ Journals More

Online First

January 28, 2020

Hepatology
TGF-β2 silencing to target biliary-derived liver diseases

Anne Dropmann, Steven Dooley, Bedair Dewidar, Seddik Hammad, Tatjana Dediulia, Julia Werle, Vanessa Hartwig, Shahrouz Ghafoory, Stefan Woelfl, Hanna Korhonen, Michel Janicot, Katja Wosikowski, Timo Itzel, Andreas Teufel, Detlef Schuppan, Ana Stojanovic, Adelheid Cerwenka, Stefanie Nittka, Albrecht Piiper, Timo Gaiser, Naiara Beraza, Malgorzata Milkiewicz, Piotr Milkiewicz, John G Brain, David E J Jones, Thomas S Weiss, Ulrich M Zanger, Matthias Ebert, Nadja M Meindl-Beinker

doi: 10.1136/gutjnl-2019-319091

January 27, 2020

GI cancer
Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer

Martin Pichler, Cristian Rodriguez-Aguayo, Su Youn Nam, Mihnea Paul Dragomir, Recep Bayraktar, Simone Anfossi, Erik Knutsen, Cristina Ivan, Enrique Fuentes-Mattei, Sang Kil Lee, Hui Ling, Tina Catela Ivkovic, Guoliang Huang, Li Huang, Yoshinaga Okugawa, Hiroyuki Katayama, Ayumu Taguchi, Emine Bayraktar, Rajat Bhattacharya, Paola Amero, William Ruixian He, Anh M Tran, Petra Vychytilova-Faltejskova, Christiane Klec, Diana L Bonilla, Xinna Zhang, Sanja Kapitanovic, Bozo Loncar, Roberta Gafà, Zhihui Wang, Vittorio Cristini, Samir M Hanash, Menashe Bar-Eli, Giovanni Lanza, Ondrej Slaby, Ajay Goel, Isidore Rigoutsos, Gabriel Lopez-Berestein, George Adrian Calin

doi: 10.1136/gutjnl-2019-318903

January 24, 2020

Inflammatory bowel disease
Addition of azathioprine to the switch of anti-TNF in patients with IBD in clinical relapse with undetectable anti-TNF trough levels and antidrug antibodies: a prospective randomised trial

Xavier Roblin, Nicolas Williet, Gilles Boschetti, Jean-Marc Phelip, Emilie Del Tedesco, Anne-Emmanuelle Berger, Philippe Vedrines, Gerard Duru, Laurent Peyrin-Biroulet, Stéphane Nancey, Bernard Flourie, Stephane Paul

doi: 10.1136/gutjnl-2019-319758
GI cancer
MiR130b from Schlafen4⁺ MDSCs stimulates epithelial proliferation and correlates with preneoplastic changes prior to gastric cancer

Lin Ding, Qian Li, Jayati Chakrabarti, Andres Munoz, Emmanuelle Faure-Kumar, Ramon Ocadiz-Ruiz, Nataliya Razumilava, Guiying Zhang, Michael H Hayes, Ricky A Sontz, Zoe Elena Mendoza, Swapna Mahurkar, Joel K Greenson, Guillermo Perez-Perez, Nguyen Thi Hong Hanh, Yana Zavros, Linda C Samuelson, Dimitrios Iliopoulos, Juanita L Merchant

doi: 10.1136/gutjnl-2019-318817
Recent advances in basic science
Regulatory T-cell therapy in Crohn’s disease: challenges and advances

Jennie N Clough, Omer S Omer, Scott Tasker, Graham M Lord, Peter M Irving

doi: 10.1136/gutjnl-2019-319850

January 23, 2020

Helicobacter pylori
Gastric microbes associated with gastric inflammation, atrophy and intestinal metaplasia 1 year after Helicobacter pylori eradication

Joseph J Y Sung, Olabisi Oluwabukola Coker, Eagle Chu, Chun Ho Szeto, Simson Tsz Yat Luk, Harry Cheuk Hay Lau, Jun Yu

doi: 10.1136/gutjnl-2019-319826
PostScript
Transgenic expression of human PRSS2 exacerbates pancreatitis in mice

Jianhua Wan, Ashley Haddock, Brandy Edenfield, Baoan Ji, Yan Bi

doi: 10.1136/gutjnl-2019-320399
PostScript
The complicated dialogue between Helicobacter pylori and p53

Zhi-Hang Tao, Jing-Yuan Fang

doi: 10.1136/gutjnl-2020-320630

January 21, 2020

Gut microbiota
Longitudinal metabolic and gut bacterial profiling of pregnant women with previous bariatric surgery

Kiana Ashley West, Chidimma Kanu, Tanya Maric, Julie Anne Kathryn McDonald, Jeremy K Nicholson, Jia V Li, Mark R Johnson, Elaine Holmes, Makrina D Savvidou

doi: 10.1136/gutjnl-2019-319620
Nutrition
Intravenous supplementation type and volume are associated with 1-year outcome and major complications in patients with chronic intestinal failure

Loris Pironi, Ezra Steiger, Francisca Joly, Geert J A Wanten, Cecile Chambrier, Umberto Aimasso, Anna Simona Sasdelli, Kinga Szczepanek, Amelia Jukes, Miriam Theilla, Marek Kunecki, Joanne Daniels, Mireille J Serlie, Sheldon C Cooper, Florian Poullenot, Henrik Højgaard Rasmussen, Charlene W Compher, Adriana Crivelli, Sarah-Jane Hughes, Lidia Santarpia, Francesco William Guglielmi, Nada Rotovnik Kozjek, Lars Ellegard, Stéphane M Schneider, Przemysław Matras, Alastair Forbes, Nicola Wyer, Anna Zmarzly, Marina Taus, Margie O'Callaghan, Emma Osland, Ronan Thibault, Cristina Cuerda, Lynn Jones, Brooke Chapman, Peter Sahin, Núria M Virgili, Andre Dong Won Lee, Paolo Orlandoni, Konrad Matysiak, Simona Di Caro, Maryana Doitchinova-Simeonova, Luisa Masconale, Corrado Spaggiari, Carmen Garde, Aurora E Serralde-Zúñiga, Gabriel Olveira, Zeljko Krznaric, Estrella Petrina Jáuregui, Ana Zugasti Murillo, José P Suárez-Llanos, Elena Nardi, André Van Gossum, Simon Lal

doi: 10.1136/gutjnl-2018-318172

January 20, 2020

Commentary
Harnessing liver progenitors in the treatment of liver fibrosis: a step in the right direction?

Katja Breitkopf-Heinlein, Wing-Kin Syn

doi: 10.1136/gutjnl-2019-320203
Stomach
DNA damage signalling as an anti-cancer barrier in gastric intestinal metaplasia

Vaidehi Krishnan, Debbie Xiu En Lim, Phuong Mai Hoang, Supriya Srivastava, Junichi Matsuo, Kie Kyon Huang, Feng Zhu, Khek Yu Ho, Jimmy Bok Yan So, Christopher Khor, Stephen Tsao, Ming Teh, Kwong Ming Fock, Tiing Leong Ang, Anand D Jeyasekharan, Patrick Tan, Khay-Guan Yeoh, Yoshiaki Ito

doi: 10.1136/gutjnl-2019-319002

January 17, 2020

GI cancer
Long-term colorectal cancer incidence after adenoma removal and the effects of surveillance on incidence: a multicentre, retrospective, cohort study

Amanda J Cross, Emma C Robbins, Kevin Pack, Iain Stenson, Paula L Kirby, Bhavita Patel, Matthew D Rutter, Andrew M Veitch, Brian P Saunders, Stephen W Duffy, Kate Wooldrage

doi: 10.1136/gutjnl-2019-320036

January 16, 2020

Gut microbiota
Influence of gastrectomy for gastric cancer treatment on faecal microbiome and metabolome profiles

Pande Putu Erawijantari, Sayaka Mizutani, Hirotsugu Shiroma, Satoshi Shiba, Takeshi Nakajima, Taku Sakamoto, Yutaka Saito, Shinji Fukuda, Shinichi Yachida, Takuji Yamada

doi: 10.1136/gutjnl-2019-319188

January 14, 2020

PostScript
Optical diagnosis of T1 CRCs and treatment consequences in the Dutch CRC screening programme

Lonne W T Meulen, Alouisa J P van de Wetering, Marie-Eline P H Debeuf, Zlatan Mujagic, Ad A M Masclee

doi: 10.1136/gutjnl-2019-320403
Guidelines
Non-steroidal anti-inflammatory drug (NSAID) therapy in patients with hypertension, cardiovascular, renal or gastrointestinal comorbidities: joint APAGE/APLAR/APSDE/APSH/APSN/PoA recommendations

Cheuk-Chun Szeto, Kentaro Sugano, Ji-Guang Wang, Kazuma Fujimoto, Samuel Whittle, Gopesh K Modi, Chen-Huen Chen, Jeong-Bae Park, Lai-Shan Tam, Kriengsak Vareesangthip, Kelvin K F Tsoi, Francis K L Chan

doi: 10.1136/gutjnl-2019-319300

January 10, 2020

PostScript
The study of Lynch syndrome in a special population reveals a strong founder effect and an unusual mutational mechanism in familial adenomatous polyposis

Abdul K Siraj, Tariq Masoodi, Rong Bu, Sandeep Kumar Parvathareddy, Sarah Siraj, Ali Alassiri, Fouad Al-Dayel, Fowzan S Alkuraya, Khawla S Al-Kuraya

doi: 10.1136/gutjnl-2019-320511

January 09, 2020

Hepatology
S100A11/ANXA2 belongs to a tumour suppressor/oncogene network deregulated early with steatosis and involved in inflammation and hepatocellular carcinoma development

Cyril Sobolewski, Daniel Abegg, Flavien Berthou, Dobrochna Dolicka, Nicolas Calo, Christine Sempoux, Margot Fournier, Christine Maeder, Anne-Sophie Ay, Pierre-Alain Clavien, Bostjan Humar, Jean-François Dufour, Alexander Adibekian, Michelangelo Foti

doi: 10.1136/gutjnl-2019-319019
Oesophagus
Histopathologist features predictive of diagnostic concordance at expert level among a large international sample of pathologists diagnosing Barrett’s dysplasia using digital pathology

Myrtle J van der Wel, Helen G Coleman, Jacques J G H M Bergman, Marnix Jansen, Sybren L Meijer on behalf of the BOLERO working group

doi: 10.1136/gutjnl-2019-318985

January 08, 2020

Commentary
Hepatitis E virus finds its path through the gut

Noémie Oechslin, Darius Moradpour, Jérôme Gouttenoire

doi: 10.1136/gutjnl-2019-320206
Inflammatory bowel disease
Automatic, computer-aided determination of endoscopic and histological inflammation in patients with mild to moderate ulcerative colitis based on red density

Peter Bossuyt, Hiroshi Nakase, Séverine Vermeire, Gert de Hertogh, Tom Eelbode, Marc Ferrante, Tadashi Hasegawa, Hilde Willekens, Yousuke Ikemoto, Takao Makino, Raf Bisschops

doi: 10.1136/gutjnl-2019-320056
Commentary
Are we ready for targeted therapy combinations in HCC?

Einat Cinnamon, Eli Pikarsky

doi: 10.1136/gutjnl-2019-319780
Helicobacter pylori
Seven-day vonoprazan and low-dose amoxicillin dual therapy as first-line Helicobacter pylori treatment: a multicentre randomised trial in Japan

Sho Suzuki, Takuji Gotoda, Chika Kusano, Hisatomo Ikehara, Ryoji Ichijima, Motoki Ohyauchi, Hirotaka Ito, Masashi Kawamura, Yohei Ogata, Masahiko Ohtaka, Moriyasu Nakahara, Koichi Kawabe

doi: 10.1136/gutjnl-2019-319954

January 06, 2020

Hepatology
The epidemiology of hepatitis delta virus infection in Cameroon

Camille Besombes, Richard Njouom, Juliette Paireau, Guillaume Lachenal, Gaëtan Texier, Mathurin Tejiokem, Simon Cauchemez, Jacques Pépin, Arnaud Fontanet

doi: 10.1136/gutjnl-2019-320027
Hepatology
Recurrent chromosomal rearrangements of ROS1, FRK and IL6 activating JAK/STAT pathway in inflammatory hepatocellular adenomas

Quentin Bayard, Stefano Caruso, Gabrielle Couchy, Sandra Rebouissou, Paulette Bioulac Sage, Charles Balabaud, Valerie Paradis, Nathalie Sturm, Anne de Muret, Catherine Guettier, Benjamin Bonsang, Christiane Copie, Eric Letouzé, Julien Calderaro, Sandrine Imbeaud, Jean-Charles Nault, Jessica Zucman-Rossi

doi: 10.1136/gutjnl-2019-319790

January 03, 2020

Inflammatory bowel disease
Adherence to a Mediterranean diet is associated with a lower risk of later-onset Crohn’s disease: results from two large prospective cohort studies

Hamed Khalili, Niclas Håkansson, Simon S Chan, Ye Chen, Paul Lochhead, Jonas F Ludvigsson, Andrew T Chan, Andrew R Hart, Ola Olén, Alicja Wolk

doi: 10.1136/gutjnl-2019-319505
Gut microbiota
Gut dysbiosis induces the development of pre-eclampsia through bacterial translocation

Xia Chen, Pan Li, Mian Liu, Huimin Zheng, Yan He, Mu-Xuan Chen, Wenli Tang, Xiaojing Yue, Yongxin Huang, Lingling Zhuang, Zhijian Wang, Mei Zhong, Guibao Ke, Haoyue Hu, Yinglin Feng, Yun Chen, Yanhong Yu, Hongwei Zhou, Liping Huang

doi: 10.1136/gutjnl-2019-319101

January 02, 2020

Gut microbiota
Impairment of spermatogenesis and sperm motility by the high-fat diet-induced dysbiosis of gut microbes

Ning Ding, Xin Zhang, Xue Di Zhang, Jun Jing, Shan Shan Liu, Yun Ping Mu, Li Li Peng, Yun Jing Yan, Geng Miao Xiao, Xin Yun Bi, Hao Chen, Fang Hong Li, Bing Yao, Allan Z Zhao

doi: 10.1136/gutjnl-2019-319127
Hepatology
Intrahepatic bacterial metataxonomic signature in non-alcoholic fatty liver disease

Silvia Sookoian, Adrian Salatino, Gustavo Osvaldo Castaño, Maria Silvia Landa, Cinthia Fijalkowky, Martin Garaycoechea, Carlos Jose Pirola

doi: 10.1136/gutjnl-2019-318811

December 26, 2019

Recent advances in clinical practice
Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting

Matias A Avila, Jean-François Dufour, Alexander L Gerbes, Fabien Zoulim, Ramon Bataller, Patrizia Burra, Helena Cortez-Pinto, Bin Gao, Ian Gilmore, Philippe Mathurin, Christophe Moreno, Vladimir Poznyak, Bernd Schnabl, Gyongyi Szabo, Maja Thiele, Mark R Thursz

doi: 10.1136/gutjnl-2019-319720

December 24, 2019

Commentary
Antibiotic use and colorectal cancer: a causal association?

Wenjie Ma, Andrew T Chan

doi: 10.1136/gutjnl-2019-319792
Editor’s quiz: GI snapshot
Dysphagia in a young female patient: it’s not always that simple

Joana Carvão, Armando Peixoto, Elisabete Rios, Guilherme Macedo

doi: 10.1136/gutjnl-2019-320307

December 23, 2019

PostScript
Reply to ‘Are the 5-hydroxymethylcytosine-based wd-scores really superior over α-fetoprotein for the early diagnosis of hepatocellular carcinoma?’

Jiabin Cai, Zhou Zhang, Chuan He, Wei Zhang, Jia Fan

doi: 10.1136/gutjnl-2019-320298

December 20, 2019

Inflammatory bowel disease
Intestinal ultrasound for monitoring therapeutic response in patients with ulcerative colitis: results from the TRUST&UC study

Christian Maaser, Frauke Petersen, Ulf Helwig, Imma Fischer, Alexander Roessler, Stefan Rath, Dorothee Lang, Torsten Kucharzik On behalf of the German IBD Study Group and the TRUST&UC study group

doi: 10.1136/gutjnl-2019-319451

December 19, 2019

GI cancer
Faecal haemoglobin concentration among subjects with negative FIT results is associated with the detection rate of neoplasia at subsequent rounds: a prospective study in the context of population based screening programmes in Italy

Carlo Senore, Marco Zappa, Cinzia Campari, Sergio Crotta, Paola Armaroli, Arrigo Arrigoni, Paola Cassoni, Rossana Colla, Mario Fracchia, Fabrizio Gili, Grazia Grazzini, Roberto Lolli, Patrizia Menozzi, Lorenzo Orione, Salvatore Polizzi, Stefano Rapi, Emilia Riggi, Tiziana Rubeca, Romano Sassatelli, Carmen Visioli, Nereo Segnan

doi: 10.1136/gutjnl-2018-318198
Helicobacter pylori
Effect of Helicobacter pylori on gastrointestinal microbiota: a population-based study in Linqu, a high-risk area of gastric cancer

Yang Guo, Yang Zhang, Markus Gerhard, Juan-Juan Gao, Raquel Mejias-Luque, Lian Zhang, Michael Vieth, Jun-Ling Ma, Monther Bajbouj, Stepan Suchanek, Wei-Dong Liu, Kurt Ulm, Michael Quante, Zhe-Xuan Li, Tong Zhou, Roland Schmid, Meinhard Classen, Wen-Qing Li, Wei-Cheng You, Kai-Feng Pan

doi: 10.1136/gutjnl-2019-319696

December 18, 2019

Gut microbiota
Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study

Magdy El-Salhy, Jan Gunnar Hatlebakk, Odd Helge Gilja, Anja Bråthen Kristoffersen, Trygve Hausken

doi: 10.1136/gutjnl-2019-319630
PostScript
Meta-analysis of the efficacy and safety of PD-1/PD-L1 inhibitors administered alone or in combination with anti-VEGF agents in advanced hepatocellular carcinoma

Zhichao Feng, Pengfei Rong, Wei Wang

doi: 10.1136/gutjnl-2019-320116

December 17, 2019

Editor’s quiz: GI snapshot
‘Blast from the past’ colonoscopy complication treated with a novel approach

Mohamed Shiha, Stuart Laidlaw, Lesley Hunt, Andrew D Hopper

doi: 10.1136/gutjnl-2019-320270
Gut microbiota
Gut microbiota of obese subjects with Prader-Willi syndrome is linked to metabolic health

Lisa M Olsson, Christine Poitou, Valentina Tremaroli, Muriel Coupaye, Judith Aron-Wisnewsky, Fredrik Bäckhed, Karine Clément, Robert Caesar

doi: 10.1136/gutjnl-2019-319322

December 16, 2019

PostScript
Decline in the incidence of colorectal cancer and the associated mortality in young Italian adults

Manuel Zorzi, Giulia Martina Cavestro, Stefano Guzzinati, Luigino Dal Maso, Massimo Rugge AIRTUM Working Group

doi: 10.1136/gutjnl-2019-320406
PostScript
Tenofovir may be superior to entecavir for preventing hepatocellular carcinoma and mortality in individuals chronically infected with HBV: a meta-analysis

Yu-Xian Teng, Min-Jun Li, Bang-De Xiang, Jian-Hong Zhong

doi: 10.1136/gutjnl-2019-320326
Guidelines
Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG)

Kevin J Monahan, Nicola Bradshaw, Sunil Dolwani, Bianca Desouza, Malcolm G Dunlop, James E East, Mohammad Ilyas, Asha Kaur, Fiona Lalloo, Andrew Latchford, Matthew D Rutter, Ian Tomlinson, Huw J W Thomas, James Hill Hereditary CRC guidelines eDelphi consensus group

doi: 10.1136/gutjnl-2019-319915
Hepatology
Number needed to treat with ursodeoxycholic acid therapy to prevent liver transplantation or death in primary biliary cholangitis

Maren H Harms, Rozanne C de Veer, Willem J Lammers, Christophe Corpechot, Douglas Thorburn, Harry L A Janssen, Keith D Lindor, Palak J Trivedi, Gideon M Hirschfield, Albert Pares, Annarosa Floreani, Marlyn J Mayo, Pietro Invernizzi, Pier Maria Battezzati, Frederik Nevens, Cyriel Y Ponsioen, Andrew L Mason, Kris V Kowdley, Bettina E Hansen, Henk R van Buuren, Adriaan J van der Meer

doi: 10.1136/gutjnl-2019-319057

December 13, 2019

PostScript
Colorectal cancer incidence in younger adults in India

Aju Mathew, Basil Baby, Kevin Wang, Bhawna Sirohi, Feintong Lei, Quan Chen, Bin Huang

doi: 10.1136/gutjnl-2019-320271

December 10, 2019

Inflammatory bowel disease
Long-term prognosis of ulcerative colitis and its temporal changes between 1986 and 2015 in a population-based cohort in the Songpa-Kangdong district of Seoul, Korea

Jae Myung Cha, Sang Hyoung Park, Kyoung Hoon Rhee, Sung Noh Hong, Young-Ho Kim, Seung In Seo, Kyung Ho Kim, Seung Kyu Jeong, Ji Hyun Lee, Sun Yong Park, Hyunju Park, Joo Sung Kim, Jong Pil Im, Hyuk Yoon, Sung Hoon Kim, Jisun Jang, Jeong Hwan Kim, Seong O Suh, Young Kyun Kim, Byong Duk Ye, Suk-Kyun Yang

doi: 10.1136/gutjnl-2019-319699
Endoscopy News
Suboptimal endoscopic cancer recognition in colorectal lesions in a national bowel screening programme

Jasper L A Vleugels, Lianne Koens, Marcel G W Dijkgraaf, Britt Houwen, Yark Hazewinkel, Paul Fockens, Evelien Dekker on behalf of the DISCOUNT study group

doi: 10.1136/gutjnl-2018-316882
Helicobacter pylori
USF1 defect drives p53 degradation during Helicobacter pylori infection and accelerates gastric carcinogenesis

Lionel Costa, Sébastien Corre, Valérie Michel, Krysten Le Luel, Julien Fernandes, Jason Ziveri, Gregory Jouvion, Anne Danckaert, Nicolas Mouchet, David Da Silva Barreira, Javier Torres, Margarita Camorlinga, Mario Milco D'Elios, Laurence Fiette, Hilde De Reuse, Marie-Dominique Galibert, Eliette Touati

doi: 10.1136/gutjnl-2019-318640

December 09, 2019

GI cancer
Systematic meta-analyses, field synopsis and global assessment of the evidence of genetic association studies in colorectal cancer

Zahra Montazeri, Xue Li, Christine Nyiraneza, Xiangyu Ma, Maria Timofeeva, Victoria Svinti, Xiangrui Meng, Yazhou He, Yacong Bo, Samuel Morgan, Sergi Castellví-Bel, Clara Ruiz-Ponte, Ceres Fernández-Rozadilla, Ángel Carracedo, Antoni Castells, Timothy Bishop, Daniel Buchanan, Mark A Jenkins, Temitope O Keku, Annika Lindblom, Fränzel J B van Duijnhoven, Anna Wu, Susan M Farrington, Malcolm G Dunlop, Harry Campbell, Evropi Theodoratou, Wei Zheng, Julian Little

doi: 10.1136/gutjnl-2019-319313

December 04, 2019

Commentary
Diagnosing pancreatic ductal adenocarcinoma using plasma extracellular vesicle RNA profiles

Adam Enver Frampton, Elisa Giovannetti

doi: 10.1136/gutjnl-2019-319896

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