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BMJ Journals More

Online First

May 17, 2019

GI bleeding
Incidences, temporal trends and risks of hospitalisation for gastrointestinal bleeding in new or chronic low-dose aspirin users after treatment for Helicobacter pylori: a territory-wide cohort study

Chuan-Guo Guo, Ka Shing Cheung, Feifei Zhang, Esther W Chan, Lijia Chen, Ian CK Wong, Wai K Leung

doi: 10.1136/gutjnl-2019-318352
GI cancer
Early evaluation using a radiomic signature of unresectable hepatic metastases to predict outcome in patients with colorectal cancer treated with FOLFIRI and bevacizumab

Anthony Dohan, Benoit Gallix, Boris Guiu, Karine Le Malicot, Caroline Reinhold, Philippe Soyer, Jaafar Bennouna, Francois Ghiringhelli, Emilie Barbier, Valérie Boige, Julien Taieb, Olivier Bouché, Eric François, Jean-Marc Phelip, Christian Borel, Roger Faroux, Jean-Francois Seitz, Stéphane Jacquot, Meher Ben Abdelghani, Faiza Khemissa-Akouz, Dominique Genet, Jean Louis Jouve, Yves Rinaldi, Françoise Desseigne, Patrick Texereau, Etienne Suc, Come Lepage, Thomas Aparico, Christine Hoeffel for the PRODIGE 9 Investigators and PRODIGE 20 Investigators

doi: 10.1136/gutjnl-2018-316407

May 16, 2019

GI cancer
Increasing incidence of colorectal cancer in young adults in Europe over the last 25 years

Fanny ER Vuik, Stella AV Nieuwenburg, Marc Bardou, Iris Lansdorp-Vogelaar, Mário Dinis-Ribeiro, Maria J Bento, Vesna Zadnik, María Pellisé, Laura Esteban, Michal F Kaminski, Stepan Suchanek, Ondřej Ngo, Ondřej Májek, Marcis Leja, Ernst J Kuipers, Manon CW Spaander

doi: 10.1136/gutjnl-2018-317592
Inflammatory bowel disease
IL23 induces IL23R recycling and amplifies innate receptor-induced signalling and cytokines in human macrophages, and the IBD-protective IL23R R381Q variant modulates these outcomes

Rui Sun, Matija Hedl, Clara Abraham

doi: 10.1136/gutjnl-2018-316830
GI cancer
Performance of colorectal cancer screening in the European Union Member States: data from the second European screening report

Carlo Senore, Partha Basu, Ahti Anttila, Antonio Ponti, Mariano Tomatis, Diama Bhadra Vale, Gugliemo Ronco, Isabelle Soerjomataram, Maja Primic-Žakelj, Emilia Riggi, Joakim Dillner, Miriam Klara Elfström, Stefan Lönnberg, Rengaswamy Sankaranarayanan, Nereo Segnan

doi: 10.1136/gutjnl-2018-317293

May 15, 2019

Inflammatory bowel disease
Mortality in adult-onset and elderly-onset IBD: a nationwide register-based cohort study 1964–2014

Ola Olén, Johan Askling, Michael C Sachs, Martin Neovius, Karin E Smedby, Anders Ekbom, Jonas F Ludvigsson

doi: 10.1136/gutjnl-2018-317572
Gut microbiota
International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis

Alasdair J Scott, James L Alexander, Claire A Merrifield, David Cunningham, Christian Jobin, Robert Brown, John Alverdy, Stephen J O’Keefe, Rex Gaskins, Julian Teare, Jun Yu, David J Hughes, Hans Verstraelen, Jeremy Burton, Paul W O’Toole, Daniel W Rosenberg, Julian R Marchesi, James M Kinross

doi: 10.1136/gutjnl-2019-318556
Inflammatory bowel disease
Non-classical monocyte homing to the gut via α4β7 integrin mediates macrophage-dependent intestinal wound healing

Lena Schleier, Maximilian Wiendl, Karin Heidbreder, Marie-Theres Binder, Raja Atreya, Timo Rath, Emily Becker, Anja Schulz-Kuhnt, Annette Stahl, Lisa Lou Schulze, Karen Ullrich, Simon F Merz, Lea Bornemann, Matthias Gunzer, Alastair J M Watson, Clemens Neufert, Imke Atreya, Markus F Neurath, Sebastian Zundler

doi: 10.1136/gutjnl-2018-316772

May 13, 2019

Upper GI cancer
Cancer cell niche factors secreted from cancer-associated fibroblast by loss of H3K27me3

Masahiro Maeda, Hideyuki Takeshima, Naoko Iida, Naoko Hattori, Satoshi Yamashita, Hiroshi Moro, Yoshimi Yasukawa, Kazuhiro Nishiyama, Taiki Hashimoto, Shigeki Sekine, Genichiro Ishii, Atsushi Ochiai, Takeo Fukagawa, Hitoshi Katai, Yoshiharu Sakai, Toshikazu Ushijima

doi: 10.1136/gutjnl-2018-317645

May 10, 2019

Commentary
Hepatocellular carcinoma: killing one bird with two stones

Marina Ruiz de Galarreta, Amaia Lujambio

doi: 10.1136/gutjnl-2019-318649
Pancreas
Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion

Hong Jiang, Xiuting Liu, Brett L Knolhoff, Samarth Hegde, Kyung Bae Lee, Hongmei Jiang, Ryan C Fields, Jonathan A Pachter, Kian-Huat Lim, David G DeNardo

doi: 10.1136/gutjnl-2018-317424
Hepatology
Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma

Man Liu, Jingying Zhou, Xiaoyu Liu, Yu Feng, Weiqin Yang, Feng Wu, Otto Ka-Wing Cheung, Hanyong Sun, Xuezhen Zeng, Wenshu Tang, Myth T S Mok, John Wong, Philip Chun Yeung, Paul Bo San Lai, Zhiwei Chen, Hongchuan Jin, Jie Chen, Stephen Lam Chan, Anthony W H Chan, Ka Fai To, Joseph J Y Sung, Minhu Chen, Alfred Sze-Lok Cheng

doi: 10.1136/gutjnl-2018-317257
Hepatology
Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis

Oliver Krenkel, Jana Hundertmark, Ali T Abdallah, Marlene Kohlhepp, Tobias Puengel, Tilmann Roth, Diogo Philippini Pontual Branco, Jana C Mossanen, Tom Luedde, Christian Trautwein, Ivan G Costa, Frank Tacke

doi: 10.1136/gutjnl-2019-318382
Hepatology
Functional microRNA screen uncovers O-linked N-acetylglucosamine transferase as a host factor modulating hepatitis C virus morphogenesis and infectivity

Katharina Herzog, Simonetta Bandiera, Sophie Pernot, Catherine Fauvelle, Frank Jühling, Amélie Weiss, Anne Bull, Sarah C Durand, Béatrice Chane-Woon-Ming, Sébastien Pfeffer, Marion Mercey, Hervé Lerat, Jean-Christophe Meunier, Wolfgang Raffelsberger, Laurent Brino, Thomas F Baumert, Mirjam B Zeisel

doi: 10.1136/gutjnl-2018-317423
PostScript
Inflammatory bowel disease and Parkinson’s disease

Elsebeth Lynge, Maria Skaalum Petersen, Søren Nymand Lophaven

doi: 10.1136/gutjnl-2019-318958
Recent advances in basic science
Leaky gut: mechanisms, measurement and clinical implications in humans

Michael Camilleri

doi: 10.1136/gutjnl-2019-318427

May 08, 2019

Stomach
HNF4α pathway mapping identifies wild-type IDH1 as a targetable metabolic node in gastric cancer

Chang Xu, Wen Fong Ooi, Aditi Qamra, Jing Tan, Benjamin Yan-Jiang Chua, Shamaine Wei Ting Ho, Kakoli Das, Zul Fazreen Adam Isa, Zhimei Li, Xiaosai Yao, Tingdong Yan, Manjie Xing, Kie Kyon Huang, Joyce Suling Lin, Tannistha Nandi, Su Ting Tay, Ming Hui Lee, Angie Lay Keng Tan, Xuewen Ong, Hassan Ashktorab, Duane Smoot, Shang Li, Shyh-Chang Ng, Bin Tean Teh, Patrick Tan

doi: 10.1136/gutjnl-2018-318025

May 04, 2019

GI cancer
Low plasma vitamin D is associated with adverse colorectal cancer survival after surgical resection, independent of systemic inflammatory response

P G Vaughan-Shaw, L Zgaga, L Y Ooi, E Theodoratou, M Timofeeva, V Svinti, M Walker, F O’Sullivan, A Ewing, S Johnston, F V N Din, H Campbell, S M Farrington, M G Dunlop

doi: 10.1136/gutjnl-2018-317922

May 03, 2019

Neurogastroenterology
Assessing telephone-delivered cognitive–behavioural therapy (CBT) and web-delivered CBT versus treatment as usual in irritable bowel syndrome (ACTIB): a multicentre randomised trial

Hazel Anne Everitt, Sabine Landau, Gilly O’Reilly, Alice Sibelli, Stephanie Hughes, Sula Windgassen, Rachel Holland, Paul Little, Paul McCrone, Felicity Bishop, Kimberley Goldsmith, Nicholas Coleman, Robert Logan, Trudie Chalder, Rona Moss-Morris on behalf of ACTIB trial group

doi: 10.1136/gutjnl-2018-317805
PostScript
Naming novel prokaryotic taxa discovered in the human gut

Aharon Oren

doi: 10.1136/gutjnl-2019-318716

April 30, 2019

PostScript
Dual histamine blockade for the treatment of adult functional dyspepsia: a single centre experience

Michael D E Potter, Thomas M Goodsall, Marjorie M Walker, Nicholas J Talley

doi: 10.1136/gutjnl-2019-318412
GI cancer
Synthetic indicator of the impact of colorectal cancer screening programmes on incidence rates

Manuel Zorzi, Marco Zappa AIRTUM Working Group

doi: 10.1136/gutjnl-2019-318589

April 29, 2019

Inflammatory bowel disease
Infants born to mothers with IBD present with altered gut microbiome that transfers abnormalities of the adaptive immune system to germ-free mice

Joana Torres, Jianzhong Hu, Akihiro Seki, Caroline Eisele, Nilendra Nair, Ruiqi Huang, Leonid Tarassishin, Bindia Jharap, Justin Cote-Daigneault, Qixing Mao, Ilaria Mogno, Graham J Britton, Mathieu Uzzan, Ching-Lynn Chen, Asher Kornbluth, James George, Peter Legnani, Elana Maser, Holly Loudon, Joanne Stone, Marla Dubinsky, Jeremiah J Faith, Jose C Clemente, Saurabh Mehandru, Jean-Frederic Colombel, Inga Peter

doi: 10.1136/gutjnl-2018-317855

April 27, 2019

PostScript
Do subjects with mild or moderate atrophic gastritis or intestinal metaplasia confined to the antrum benefit from gastric cancer surveillance?

Duc Trong Quach, Toru Hiyama, Takuji Gotoda

doi: 10.1136/gutjnl-2019-318720
GI cancer
Development and validation of a prediction rule for estimating gastric cancer risk in the Chinese high-risk population: a nationwide multicentre study

Quancai Cai, Chunping Zhu, Yuan Yuan, Qi Feng, Yichao Feng, Yingxia Hao, Jichang Li, Kaiguang Zhang, Guoliang Ye, Liping Ye, Nonghua Lv, Shengsheng Zhang, Chengxia Liu, Mingquan Li, Qi Liu, Rongzhou Li, Jie Pan, Xiaocui Yang, Xuqing Zhu, Yumei Li, Bo Lao, Ansheng Ling, Honghui Chen, Xiuling Li, Ping Xu, Jianfeng Zhou, Baozhen Liu, Zhiqiang Du, Yiqi Du, Zhaoshen Li Gastrointestinal Early Cancer Prevention & Treatment Alliance of China (GECA)

doi: 10.1136/gutjnl-2018-317556
Inflammatory bowel disease
A blood-based prognostic biomarker in IBD

Daniele Biasci, James C Lee, Nurulamin M Noor, Diana R Pombal, Monica Hou, Nina Lewis, Tariq Ahmad, Ailsa Hart, Miles Parkes, Eoin F McKinney, Paul A Lyons, Kenneth G C Smith

doi: 10.1136/gutjnl-2019-318343
Editor’s quiz: GI snapshot
Unusual gastric lesion in an iron-deficient patient

Kathleen Bryce, Mark Hawthorne, Iain Ewing

doi: 10.1136/gutjnl-2019-318646

April 26, 2019

Editor’s quiz: GI snapshot
Jejunal perforation and central retinal vein occlusion in a 55-year-old European man

Amanda Louise Thomas, Lukes Summers, James R Goodhand, Sarah Saunders

doi: 10.1136/gutjnl-2019-318342
Commentary
Is colonic propionate delivery a novel solution to improve metabolism and inflammation in overweight or obese subjects?

Patrice D Cani

doi: 10.1136/gutjnl-2019-318776
Neurogastroenterology
Efficacy of pharmacological therapies in patients with IBS with diarrhoea or mixed stool pattern: systematic review and network meta-analysis

Christopher J Black, Nicholas E Burr, Michael Camilleri, David L Earnest, Eamonn MM Quigley, Paul Moayyedi, Lesley A Houghton, Alexander C Ford

doi: 10.1136/gutjnl-2018-318160
Colon
Prospective colonoscopic study to investigate risk of colorectal neoplasms in first-degree relatives of patients with non-advanced adenomas

Siew C Ng, Moe Htet Kyaw, Bing Yee Suen, Yee Kit Tse, Martin C S Wong, Aric J Hui, Hui Yee Tak, James Y W Lau, Joseph J Y Sung, Francis K L Chan

doi: 10.1136/gutjnl-2018-318117
Commentary
Microbiota as a cornerstone in the development of primary sclerosing cholangitis: paving the path for translational diagnostic and therapeutic approaches

Catherine Mooser, Stephanie Christine Ganal-Vonarburg

doi: 10.1136/gutjnl-2019-318487

April 25, 2019

Editor’s quiz: GI snapshot
IIc or not IIc: a question for meticulous optical evaluation

Neal Shahidi, Mayenaaz Sidhu, Iddo Bar-Yishay, Michael J Bourke

doi: 10.1136/gutjnl-2019-318616

April 20, 2019

PostScript
Novel p.K374E variant of CPA1 causes misfolding-induced hereditary pancreatitis with autosomal dominant inheritance

Balázs Csaba Németh, Anna Orekhova, Wenying Zhang, Shannon A Nortman, Tyler Thompson, Péter Hegyi, Maisam Abu-El-Haija

doi: 10.1136/gutjnl-2019-318751

April 19, 2019

Gut microbiota
Fungi participate in the dysbiosis of gut microbiota in patients with primary sclerosing cholangitis

Sara Lemoinne, Astrid Kemgang, Karima Ben Belkacem, Marjolène Straube, Sarah Jegou, Christophe Corpechot, Saint-Antoine IBD Network, Olivier Chazouillères, Chantal Housset, Harry Sokol

doi: 10.1136/gutjnl-2018-317791

April 17, 2019

PostScript
Concerns regarding the recommendations of the British Society of Gastroenterology’s lower GI bleeding guidelines

Ajay M Verma, Neeraj Bhala, Andrew Chilton, Benjamin R Disney

doi: 10.1136/gutjnl-2019-318582
Editor’s quiz: GI snapshot
Biliary dilatation in a 67-year-old woman: seeing is believing

Peng Pan, Sheng-bing Zhao, Shuling Wang, Zhaoshen Li, Yu Bai

doi: 10.1136/gutjnl-2018-318200
PostScript
Degree of STING activation is associated with disease outcomes

Qiongyuan Hu, Jie Wu, Yanhan Ren, Xiuwen Wu, Lin Gao, Gefei Wang, Guosheng Gu, Huajian Ren, Zhiwu Hong, Dominic A Slade, Jianan Ren

doi: 10.1136/gutjnl-2019-318597

April 13, 2019

GI cancer
Personalised surveillance for serrated polyposis syndrome: results from a prospective 5-year international cohort study

Arne GC Bleijenberg, Joep EG IJspeert, Yasmijn J van Herwaarden, Sabela Carballal, María Pellisé, Gerhard Jung, Tanya M Bisseling, Iris D Nagetaal, Monique E van Leerdam, Niels van Lelyveld, Xavier Bessa, Francisco Rodríguez-Moranta, Barbara Bastiaansen, Willemijn de Klaver, Liseth Rivero, Manon CW Spaander, Jan Jacob Koornstra, Luis Bujanda, Francesc Balaguer, Evelien Dekker

doi: 10.1136/gutjnl-2018-318134

April 12, 2019

Inflammatory bowel disease
Designing clinical trials in paediatric inflammatory bowel diseases: a PIBDnet commentary

Dan Turner, Anne M Griffiths, David Wilson, Diane R Mould, Robert N Baldassano, Richard K Russell, Marla Dubinsky, Melvin B Heyman, Lissy de Ridder, Jeffrey Hyams, Javier Martin de Carpi, Laurie Conklin, William A Faubion, Sibylle Koletzko, Athos Bousvaros, Frank M Ruemmele

doi: 10.1136/gutjnl-2018-317987
Hepatology
Polyploidy spectrum: a new marker in HCC classification

Myriam Bou-Nader, Stefano Caruso, Romain Donne, Séverine Celton-Morizur, Julien Calderaro, Géraldine Gentric, Mathilde Cadoux, Antoine L’Hermitte, Christophe Klein, Thomas Guilbert, Miguel Albuquerque, Gabrielle Couchy, Valérie Paradis, Jean-Pierre Couty, Jessica Zucman-Rossi, Chantal Desdouets

doi: 10.1136/gutjnl-2018-318021

April 10, 2019

Endoscopy
Integrating next-generation sequencing to endoscopic retrograde cholangiopancreatography (ERCP)-obtained biliary specimens improves the detection and management of patients with malignant bile duct strictures

Aatur D Singhi, Marina N Nikiforova, Jennifer Chennat, Georgios I Papachristou, Asif Khalid, Mordechai Rabinovitz, Rohit Das, Savreet Sarkaria, M Samir Ayasso, Abigail I Wald, Sara E Monaco, Michael Nalesnik, N Paul Ohori, David Geller, Allan Tsung, Amer H Zureikat, Herbert Zeh, J Wallis Marsh, Melissa Hogg, Kenneth Lee, David L Bartlett, James F Pingpank, Abhinav Humar, Nathan Bahary, Anil K Dasyam, Randall Brand, Kenneth E Fasanella, Kevin McGrath, Adam Slivka

doi: 10.1136/gutjnl-2018-317817
Gut microbiota
Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial

Edward S Chambers, Claire S Byrne, Douglas J Morrison, Kevin G Murphy, Tom Preston, Catriona Tedford, Isabel Garcia-Perez, Sofia Fountana, Jose Ivan Serrano-Contreras, Elaine Holmes, Catherine J Reynolds, Jordie F Roberts, Rosemary J Boyton, Daniel M Altmann, Julie A K McDonald, Julian R Marchesi, Arne N Akbar, Natalie E Riddell, Gareth A Wallis, Gary S Frost

doi: 10.1136/gutjnl-2019-318424

April 09, 2019

PostScript
Hepatitis D: not a rare disease anymore: global update for 2017–2018

Dan-Ting Shen, Dong-Ze Ji, Hai-Yan Chen, Hemant Goyal, Shiyang Pan, Hua-Guo Xu

doi: 10.1136/gutjnl-2019-318691
Commentary
Hepatocellular adenomas: one step beyond

Jean-Yves Scoazec

doi: 10.1136/gutjnl-2019-318299

April 06, 2019

Pancreas
Ring1b-dependent epigenetic remodelling is an essential prerequisite for pancreatic carcinogenesis

Simone Benitz, Tobias Straub, Ujjwal Mukund Mahajan, Jurik Mutter, Stefan Czemmel, Tatjana Unruh, Britta Wingerath, Sabrina Deubler, Lisa Fahr, Tao Cheng, Sven Nahnsen, Philipp Bruns, Bo Kong, Susanne Raulefs, Güralp O Ceyhan, Julia Mayerle, Katja Steiger, Irene Esposito, Jörg Kleeff, Christoph W Michalski, Ivonne Regel

doi: 10.1136/gutjnl-2018-317208
Hepatology
Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans

Li Che, Wenna Chi, Yu Qiao, Jie Zhang, Xinhua Song, Ye Liu, Lei Li, Jiaoyuan Jia, Maria G Pilo, Jingxiao Wang, Antonio Cigliano, Zhilong Ma, Wenhua Kuang, Zefang Tang, Zemin Zhang, Guanghou Shui, Silvia Ribback, Frank Dombrowski, Matthias Evert, Rosa Maria Pascale, Carla Cossu, Giovanni Mario Pes, Timothy F Osborne, Diego F Calvisi, Xin Chen, Ligong Chen

doi: 10.1136/gutjnl-2018-317581
PostScript
Response to: ‘Circulating microbiome in blood of different circulatory compartments’ by Schierwagen et al

Bastian Volker Helmut Hornung, Romy Danielle Zwittink, Quinten Raymond Ducarmon, Ed J Kuijper

doi: 10.1136/gutjnl-2019-318601
PostScript
Scoring endoscopic disease activity in IBD: artificial intelligence sees more and better than we do

Peter Bossuyt, Séverine Vermeire, Raf Bisschops

doi: 10.1136/gutjnl-2019-318235

March 30, 2019

Inflammatory bowel disease
Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis

Sjoerd van der Post, Karolina S Jabbar, George Birchenough, Liisa Arike, Noreen Akhtar, Henrik Sjovall, Malin E V Johansson, Gunnar C Hansson

doi: 10.1136/gutjnl-2018-317571

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