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BMJ Journals

Online First

October 04, 2024

Hepatology
Systemic messenger RNA replacement therapy is effective in a novel clinically relevant model of acute intermittent porphyria developed in non-human primates

Karol M Córdoba, Daniel Jericó, Lei Jiang, María Collantes, Manuel Alegre, Leyre García-Ruiz, Oscar Manzanilla, Ana Sampedro, Jose M Herranz, Iñigo Insausti, Antonio Martinez de la Cuesta, Francesco Urigo, Patricia Alcaide, María Morán, Miguel A Martín, José Luis Lanciego, Thibaud Lefebvre, Laurent Gouya, Gemma Quinconces, Carmen Unzu, Sandra Hervas-Stubbs, Juan M Falcón-Pérez, Estíbaliz Alegre, Azucena Aldaz, María A Fernández-Seara, Iván Peñuelas, Pedro Berraondo, Paolo G V Martini, Matias A Avila, Antonio Fontanellas

doi: 10.1136/gutjnl-2024-332619
Letter
Exploring the role of genetics, gut microbiota and blood metabolites in IBD

Yiwen Yuan, Xi Fu, Yiqun Deng, Yu Sun

doi: 10.1136/gutjnl-2024-333611

October 02, 2024

Letter
Unravelling lipidomic disruptions across multiple tissues in Chd8-mutant ASD mice through integration of lipidomics and single-cell transcriptomics

You Yu, Bing Zhang, Ning Wang, Zhenqiang Zuo, Peifeng Ji, Fangqing Zhao

doi: 10.1136/gutjnl-2024-332972
Letter
Environmental and healthcare trade-offs between single-use and reusable gastroscopes

Jiashu Han, Dan Shan

doi: 10.1136/gutjnl-2024-333827
Gut microbiota
Multiomics of the intestine-liver-adipose axis in multiple studies unveils a consistent link of the gut microbiota and the antiviral response with systemic glucose metabolism

Anna Castells-Nobau, José Maria Moreno-Navarrete, Lisset de la Vega-Correa, Irene Puig, Massimo Federici, Jiuwen Sun, Remy Burcelin, Laurence Guzylack-Piriou, Pierre Gourdy, Laurent Cazals, María Arnoriaga-Rodríguez, Gema Frühbeck, Luisa Maria Seoane, José López-Miranda, Francisco J Tinahones, Carlos Dieguez, Marc-Emmanuel Dumas, Vicente Pérez-Brocal, Andrés Moya, Nikolaos Perakakis, Geltrude Mingrone, Stefan Bornstein, Jose Ignacio Rodriguez Hermosa, Ernesto Castro, Jose Manuel Fernández-Real, Jordi Mayneris-Perxachs

doi: 10.1136/gutjnl-2024-332602
Commentary
Need for standardised approaches to human microbiome research using the example of colorectal neoplasia research

Sarah Manning, Rashmi Sinha, Colin J Rees

doi: 10.1136/gutjnl-2024-333765

October 01, 2024

Upper GI cancer
p53 mutation biases squamocolumnar junction progenitor cells towards dysplasia rather than metaplasia in Barrett’s oesophagus

Guodong Lian, Ermanno Malagola, Chengguo Wei, Qiongyu Shi, Junfei Zhao, Masahiro Hata, Hiroki Kobayashi, Yosuke Ochiai, Biyun Zheng, Xiaofei Zhi, Feijing Wu, Ruhong Tu, Osmel Companioni Nápoles, Wenjing Su, Leping Li, Changqing Jing, Man Chen, Leah Zamechek, Richard Friedman, Karol Nowicki-Osuch, Michael Quante, Jianwen Que, Timothy C Wang

doi: 10.1136/gutjnl-2024-332095
Hepatology
Establishment of enterically transmitted hepatitis virus animal models using lipid nanoparticle-based full-length viral genome RNA delivery system

Tianxu Liu, Jian Li, Xin Yin, Fengmin Lu, Hui Zhao, Lin Wang, Cheng-Feng Qin

doi: 10.1136/gutjnl-2024-332784

September 30, 2024

Hepatology
Nuclear translocation of plasma membrane protein ADCY7 potentiates T cell-mediated antitumour immunity in HCC

Jianan Chen, Youhai Jiang, Minghui Hou, Chunliang Liu, Erdong Liu, Yali Zong, Xiang Wang, Zhengyuan Meng, Mingye Gu, Yu Su, Hongyang Wang, Jing Fu

doi: 10.1136/gutjnl-2024-332902
Endoscopy
Impact of margin thermal ablation after endoscopic mucosal resection of large (≥20 mm) non-pedunculated colonic polyps on long-term recurrence

Timothy O’Sullivan, Francesco Vito Mandarino, Julia L Gauci, Anthony M Whitfield, Clarence Kerrison, James Elhindi, Catarina Neto do Nascimento, Sunil Gupta, Oliver Cronin, Anthony Sakiris, Juan Francisco Prieto Aparicio, Sophie Arndtz, Gregor Brown, Spiro Raftopoulos, David Tate, Eric Y Lee, Stephen J Williams, Nicholas Burgess, Michael J Bourke

doi: 10.1136/gutjnl-2024-332907
Hepatology
Spatial single-cell profiling and neighbourhood analysis reveal the determinants of immune architecture connected to checkpoint inhibitor therapy outcome in hepatocellular carcinoma

Henrike Salié, Lara Wischer, Antonio D’Alessio, Ira Godbole, Yuan Suo, Patricia Otto-Mora, Juergen Beck, Olaf Neumann, Albrecht Stenzinger, Peter Schirmacher, Claudia A M Fulgenzi, Andreas Blaumeiser, Melanie Boerries, Natascha Roehlen, Michael Schultheiß, Maike Hofmann, Robert Thimme, David J Pinato, Thomas Longerich, Bertram Bengsch

doi: 10.1136/gutjnl-2024-332837

September 25, 2024

Letter
Variceal band ligation and carvedilol: together forever, or not?

Philip D J Dunne, Ewan H Forrest, Adrian J Stanley

doi: 10.1136/gutjnl-2024-333643
Pancreas
Metabolic reprogramming by mutant GNAS creates an actionable dependency in intraductal papillary mucinous neoplasms of the pancreas

Yuki Makino, Kimal I Rajapakshe, Benson Chellakkan Selvanesan, Takashi Okumura, Kenjiro Date, Prasanta Dutta, Lotfi Abou-Elkacem, Akiko Sagara, Jimin Min, Marta Sans, Nathaniel Yee, Megan J Siemann, Jose Enriquez, Paytience Smith, Pratip Bhattacharya, Michael Kim, Merve Dede, Traver Hart, Anirban Maitra, Fredrik Ivar Thege

doi: 10.1136/gutjnl-2024-332412

September 24, 2024

Commentary
Alcohol-associated hepatitis: a neutrophile disease?

Maximilian Joseph Brol, Ali Canbay, Jonel Trebicka

doi: 10.1136/gutjnl-2024-333222

September 19, 2024

Letter
Rethinking routine mapping biopsies in gastric intestinal metaplasia: justification for endoscopic stratification

Duc Trong Quach, Toru Hiyama, Gwang Ha Kim, Takuji Gotoda, Kentaro Sugano

doi: 10.1136/gutjnl-2024-333773

September 18, 2024

Commentary
Commentary on: the management of patients with gastric intestinal metaplasia

David Y Graham, Yi-Chia Lee

doi: 10.1136/gutjnl-2024-333684
Commentary
High-risk varices in patients with Child-Pugh-Turcotte B and C: consider band ligation with carvedilol for preventing first variceal bleeding, especially in patients with MASLD-associated cirrhosis

Alexander Zipprich, Ruben Hernaez

doi: 10.1136/gutjnl-2024-333263
Commentary
Statins for MAFLD/MASH: another brick in the wall while waiting for final answers

Jaime Bosch

doi: 10.1136/gutjnl-2024-333426

September 17, 2024

Letter
Cold EMR, hot EMR or ESD for large benign adenoma: not one size fits all

Veronique Van der Voort, Cesare Hassan, Alessandro Repici, Romain Legros, Mathieu Pioche, Jérémie Jacques

doi: 10.1136/gutjnl-2024-333490

September 13, 2024

Recent advances in basic science
Targeting TL1A and DR3: the new frontier of anti-cytokine therapy in IBD

Giorgos Bamias, Paola Menghini, Theresa T Pizarro, Fabio Cominelli

doi: 10.1136/gutjnl-2024-332504

September 12, 2024

Hepatology
Long-term hepatitis B surface antigen response after finite treatment of ARC-520 or JNJ-3989

Lung Yi Mak, Christine I Wooddell, Oliver Lenz, Thomas Schluep, James Hamilton, Heather L Davis, Xianhua Mao, Wai-Kay Seto, Michael Biermer, Man-Fung Yuen

doi: 10.1136/gutjnl-2024-333026

September 11, 2024

Letter
Extending inflamed-class signature to predict immune checkpoint inhibitor-based combination therapy in hepatocellular carcinoma

Wenhua You, Chupeng Hu, Mengya Zhao, Yuhan Zhang, Jinying Lu, Yedi Huang, Ling Li, Yun Chen

doi: 10.1136/gutjnl-2024-333375
Hepatology
Identification of PRMT5 as a therapeutic target in cholangiocarcinoma

Jasmin Elurbide, Leticia Colyn, Maria U Latasa, Iker Uriarte, Stefano Mariani, Amaya Lopez-Pascual, Emiliana Valbuena, Borja Castello-Uribe, Robert Arnes-Benito, Elena Adan-Villaescusa, Luz A Martinez-Perez, Mikel Azkargorta, Felix Elortza, Hanghang Wu, Marcin Krawczyk, Kai Markus Schneider, Bruno Sangro, Luca Aldrighetti, Francesca Ratti, Andrea Casadei Gardini, Jose J G Marin, Irene Amat, Jesus M Urman, Maria Arechederra, Maria Luz Martinez-Chantar, Christian Trautwein, Meritxell Huch, Francisco Javier Cubero, Carmen Berasain, Maite G Fernandez-Barrena, Matias A Avila

doi: 10.1136/gutjnl-2024-332998

September 10, 2024

Letter
AlphaMissense versus laboratory-based pathogenicity prediction of 13 novel missense CPA1 variants from pancreatitis cases

Máté Sándor, Isabelle Scheers, Atsushi Masamune, Heiko Witt, Jessica LaRusch, Jian-Min Chen, Balázs Csaba Németh, Andrea Geisz, Aliye Uc, Miklós Sahin-Tóth

doi: 10.1136/gutjnl-2024-333697

September 09, 2024

Gut microbiota
Microbiota-induced S100A11-RAGE axis underlies immune evasion in right-sided colon adenomas and is a therapeutic target to boost anti-PD1 efficacy

Qiming Zhou, Linhan Lei, Junhong Cheng, Junyou Chen, Yuyang Du, Xuehua Zhang, Qing Li, Chuangen Li, Haijun Deng, Chi Chun Wong, Baoxiong Zhuang, Guoxin Li, Xiaowu Bai

doi: 10.1136/gutjnl-2024-332193

September 07, 2024

Endoscopy
Sphincterotomy for biliary sphincter of Oddi disorder and idiopathic acute recurrent pancreatitis: the RESPOnD longitudinal cohort

Gregory A Coté, Badih Joseph Elmunzer, Haley Nitchie, Richard S Kwon, Field Willingham, Sachin Wani, Vladimir Kushnir, Amitabh Chak, Vikesh Singh, Georgios I Papachristou, Adam Slivka, Martin Freeman, Srinivas Gaddam, Priya Jamidar, Paul Tarnasky, Shyam Varadarajulu, Lydia D Foster, Peter Cotton

doi: 10.1136/gutjnl-2024-332686

September 06, 2024

GI cancer
Epidemiology of gastrointestinal cancers: a systematic analysis from the Global Burden of Disease Study 2021

Pojsakorn Danpanichkul, Kanokphong Suparan, Primrose Tothanarungroj, Disatorn Dejvajara, Krittameth Rakwong, Yanfang Pang, Romelia Barba, Jerapas Thongpiya, Michael B Fallon, Denise Harnois, Rashid N Lui, Michael B Wallace, Ju Dong Yang, Lewis R Roberts, Karn Wijarnpreecha

doi: 10.1136/gutjnl-2024-333227
Hepatology
Risk of hepatic events associated with use of sodium-glucose cotransporter-2 inhibitors versus glucagon-like peptide-1 receptor agonists, and thiazolidinediones among patients with metabolic dysfunction-associated steatotic liver disease

Sungho Bea, Hwa Yeon Ko, Jae Hyun Bae, Young Min Cho, Yoosoo Chang, Seungho Ryu, Christopher D Byrne, Ju-Young Shin

doi: 10.1136/gutjnl-2024-332687
Commentary
Cholesterol’s new tricks propel MASH-HCC: impact in immunotherapy

Carmen Garcia-Ruiz, Sandra Torres, Jose C Fernandez-Checa

doi: 10.1136/gutjnl-2024-332766

September 04, 2024

Recent advances in clinical practice
Where are we with gastric cancer screening in Europe in 2024?

Mārcis Leja

doi: 10.1136/gutjnl-2024-332705

August 31, 2024

Pancreas
MED12 loss activates endogenous retroelements to sensitise immunotherapy in pancreatic cancer

Yingying Tang, Shijie Tang, Wenjuan Yang, Zhengyan Zhang, Teng Wang, Yuyun Wu, Junyi Xu, Christian Pilarsky, Massimiliano Mazzone, Lei-Wei Wang, Yongwei Sun, Ruijun Tian, Yujie Tang, Yu Wang, Chaochen Wang, Jing Xue

doi: 10.1136/gutjnl-2024-332350

August 30, 2024

Recent advances in basic science
Emerging role of environmental pollutants in inflammatory bowel disease risk, outcomes and underlying mechanisms

Maria Manuela Estevinho, Vishal Midya, Shirley Cohen-Mekelburg, Kristine Højgaard Allin, Mathurin Fumery, Salome S Pinho, Jean-Frederic Colombel, Manasi Agrawal

doi: 10.1136/gutjnl-2024-332523
Editor’s quiz: GI snapshot
Hepatomegaly and ascites in a patient with UC

Jintong Chen, Ye Xu, Yanjun Lin, Chengdang Wang

doi: 10.1136/gutjnl-2024-333587
Letter
Sex-based differences in prescribed medications, surgical procedures and disease-related complications in IBD

Celine Cumming, Emad Mansoor, Jaime Abraham Perez, Davide Pietropaoli, Rita Del Pinto, Theresa T Pizarro

doi: 10.1136/gutjnl-2024-332318
Pancreas
CD64⁺ fibroblast-targeted vilanterol and a STING agonist augment CLDN18.2 BiTEs efficacy against pancreatic cancer by reducing desmoplasia and enriching stem-like CD8⁺ T cells

Tianxing Zhou, Xupeng Hou, Jingrui Yan, Lin Li, Yongjie Xie, Weiwei Bai, Wenna Jiang, Yiping Zou, Xueyang Li, Ziyun Liu, Zhaoyu Zhang, Bohang Xu, Guohua Mao, Yifei Wang, Song Gao, Xiuchao Wang, Tiansuo Zhao, Hongwei Wang, Hongxia Sun, Xiufeng Zhang, Jun Yu, Chongbiao Huang, Jing Liu, Jihui Hao

doi: 10.1136/gutjnl-2024-332371
Letter
Colectomy in microscopic colitis: a rare indication

David Bergman, Anders Forss, Jiangwei Sun, Fahim Ebrahimi, Jonas F Ludvigsson

doi: 10.1136/gutjnl-2024-333505
Commentary
Breast milk components modulate gut microbiota to increase susceptibility to atopic dermatitis in early life

Ruiqi Zhang, Jinfeng Wang

doi: 10.1136/gutjnl-2024-333235

August 29, 2024

Letter
Letter to the editor: Autoimmune gastritis may be less susceptible to cancer development than Helicobacter pylori-related gastritis based on histological analysis

Zijin Liu, Jiayi Hong, Fang He

doi: 10.1136/gutjnl-2024-333604
Commentary
The Q for immune evasion in HCC: ER stress in myeloid cells

Charlotte Rennert, Maike Hofmann

doi: 10.1136/gutjnl-2024-333249

August 23, 2024

Commentary
Is mailed outreach and patient navigation a perfect solution to improve HCC screening?

Iuliana Pompilia Radu

doi: 10.1136/gutjnl-2024-332920

August 22, 2024

Recent advances in basic science
Artificial intelligence applied to ‘omics data in liver disease: towards a personalised approach for diagnosis, prognosis and treatment

Soumita Ghosh, Xun Zhao, Mouaid Alim, Michael Brudno, Mamatha Bhat

doi: 10.1136/gutjnl-2023-331740
Letter
Morphological consistency between EUS and ERCP in diagnosing biliary sludge and microlithiasis

Chen Shi, Jianglong Hong, Bingqing Bai, Suwen Li, Lihong Chen, Hao Ding, Zhangwei Xu, Junjun Bao, Qiao Mei

doi: 10.1136/gutjnl-2024-332971

August 19, 2024

Letter
Guidelines Development Group for the British Society of Gastroenterology guidelines for the diagnosis and management of cholangiocarcinoma

Shahid A Khan, Simon M Rushbrook, Timothy James Kendall, Yoh Zen, Raneem Albazaz, Prakash Manoharan, Stephen P Pereira, Richard Sturgess, Brian R Davidson, Hassan Z Malik, Derek Manas, Nigel Heaton, K Raj Prasad, Juan W Valle, Rebecca Goody, Maria Hawkins, Wendy Prentice, Helen Morement, Martine Walmsley, John Bridgewater

doi: 10.1136/gutjnl-2024-333359

August 17, 2024

Commentary
Definite benefits of GLP-1 receptor agonists: what is the risk of gastroparesis and lung aspiration?

Michael Camilleri

doi: 10.1136/gutjnl-2024-333036
Coeliac disease
Clinical outcomes of potential coeliac disease: a systematic review and meta-analysis

Mohamed G Shiha, Annalisa Schiepatti, Stiliano Maimaris, NIcoletta Nandi, Hugo A Penny, David S Sanders

doi: 10.1136/gutjnl-2024-333110

August 15, 2024

Letter
Reassessing gastroscopy practices: the need for improved methodology and interpretation – author’s reply

David Robert Beaton, Linda Sharp, Matthew D Rutter

doi: 10.1136/gutjnl-2024-333437

August 12, 2024

Inflammatory bowel disease
External validation of serum biomarkers predicting short-term and mid/long-term relapse in patients with Crohn’s disease stopping infliximab

Nicolas Pierre, Vân Anh Huynh-Thu, Dominique Baiwir, Gabriel Mazzucchelli, Maximilien Fléron, Lisette Trzpiot, Gauthier Eppe, Edwin De Pauw, David Laharie, Jack Satsangi, Peter Bossuyt, Lucine Vuitton, Sophie Vieujean, Jean-Frédéric Colombel, Marie-Alice Meuwis, Edouard Louis GETAID and the SPARE-Biocycle research group

doi: 10.1136/gutjnl-2024-332648

August 09, 2024

Inflammatory bowel disease
Age-related patterns of microbial dysbiosis in multiplex inflammatory bowel disease families

Jonathan P Jacobs, Elizabeth A Spencer, Drew S Helmus, Julianne C Yang, Venu Lagishetty, Gerold Bongers, Graham Britton, Kyle Gettler, Pamela Reyes-Mercedes, Jianzhong Hu, Amy Hart, Esi Lamousé-Smith, Jan Wehkamp, Carol Landers, Philip Debbas, Joana Torres, Jean-Frederic Colombel, Judy Cho, Inga Peter, Jeremiah Faith, Jonathan Braun, Marla Dubinsky

doi: 10.1136/gutjnl-2024-332475

August 08, 2024

Letter
Direct toll-like receptor triggering in colorectal cancer-associated stromal cells elicits immunostimulatory properties leading to enhanced immune cell recruitment

Julija Djordjevic, Nubia Sarahi Cisneros Romero, Luciano Cascione, Valentina Mele, Eleonora Cremonesi, Elisa Sorrenti, Camilla Basso, Martina Villa, Agnese Cianfarani, Raffaello Roesel, Jacopo Galafassi, Pietro Edoardo Majno-Hurst, Giulio Spagnoli, Dimitrios Christoforidis, Giandomenica Iezzi

doi: 10.1136/gutjnl-2023-331759
Hepatology
Synergistic association of sodium-glucose cotransporter-2 inhibitor and metformin on liver and non-liver complications in patients with type 2 diabetes mellitus and metabolic dysfunction-associated steatotic liver disease

Xianhua Mao, Xinrong Zhang, Leslie Kam, Nicholas Chien, Rongtao Lai, Ka-Shing Cheung, Man-Fung Yuen, Ramsey Cheung, Wai-Kay Seto, Mindie H Nguyen

doi: 10.1136/gutjnl-2024-332481

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