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BMJ Journals More

Online First

March 22, 2019

Hepatology
Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade

Ying Zhu, Jing Yang, Da Xu, Xiao-Mei Gao, Ze Zhang, Jennifer L. Hsu, Chia-Wei Li, Seung-Oe Lim, Yuan-Yuan Sheng, Yu Zhang, Jian-Hua Li, Qin Luo, Yan Zheng, Yue Zhao, Lu Lu, Hu-Liang Jia, Mien-Chie Hung, Qiong-Zhu Dong, Lun-Xiu Qin

doi: 10.1136/gutjnl-2019-318419

March 20, 2019

PostScript
Depression in inflammatory bowel disease: risk factor, prodrome or extraintestinal manifestation? Reply from authors

Alexandra D Frolkis, Isabelle A Vallerand, Scott B Patten, Gilaad G Kaplan

doi: 10.1136/gutjnl-2019-318650

March 19, 2019

Colon
Crypt fusion as a homeostatic mechanism in the human colon

Ann-Marie Baker, Calum Gabbutt, Marc J Williams, Biancastella Cereser, Noor Jawad, Manuel Rodriguez-Justo, Marnix Jansen, Chris P Barnes, Benjamin D Simons, Stuart AC McDonald, Trevor A Graham, Nicholas A Wright

doi: 10.1136/gutjnl-2018-317540
Commentary
Chromatin remodelling controls pancreatic tissue fate

Elisabeth Hessmann, Volker Ellenrieder

doi: 10.1136/gutjnl-2018-317486

March 18, 2019

Commentary
Plasticity of adult hepatocytes and readjustment of cell fate: a novel dogma in liver disease

Francisco Javier Cubero, Maria Luz Martinez-Chantar

doi: 10.1136/gutjnl-2019-318218

March 16, 2019

Hepatology
Age independent survival benefit for patients with hepatocellular carcinoma (HCC) without metastases at diagnosis: a population-based study

Enrico N De Toni, Anne Schlesinger-Raab, Martin Fuchs, Wolfgang Schepp, Ursula Ehmer, Fabian Geisler, Jens Ricke, Philipp Paprottka, Helmut Friess, Jens Werner, Alexander L Gerbes, Julia Mayerle, Jutta Engel

doi: 10.1136/gutjnl-2018-318193
Editor’s quiz: GI snapshot
Oesophageal and scaly skin lesions associated with chronic cholestatic liver disease

Philipp Kasper, Tobias Goeser, Dirk Nierhoff

doi: 10.1136/gutjnl-2019-318502

March 14, 2019

Oesophagus
Estimating neoplasia detection rate (NDR) in patients with Barrett’s oesophagus based on index endoscopy: a systematic review and meta-analysis

Sravanthi Parasa, Madhav Desai, Anusha Vittal, Viveksandeep T Chandrasekar, Asad Pervez, Kevin F Kennedy, Neil Gupta, Nicholas J Shaheen, Prateek Sharma

doi: 10.1136/gutjnl-2018-317800
Hepatology
Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis

Lijun Liao, Kai Markus Schneider, Eric J C Galvez, Mick Frissen, Hanns-Ulrich Marschall, Huan Su, Maximilian Hatting, Annika Wahlström, Johannes Haybaeck, Philip Puchas, Antje Mohs, Jin Peng, Ina Bergheim, Anika Nier, Julia Hennings, Johanna Reißing, Henning W Zimmermann, Thomas Longerich, Till Strowig, Christian Liedtke, Francisco J Cubero, Christian Trautwein

doi: 10.1136/gutjnl-2018-316670
Pancreas
Enrichment of oral microbiota in early cystic precursors to invasive pancreatic cancer

Rogier Aäron Gaiser, Asif Halimi, Hassan Alkharaan, Liyan Lu, Haleh Davanian, Katie Healy, Luisa W Hugerth, Zeeshan Ateeb, Roberto Valente, Carlos Fernández Moro, Marco Del Chiaro, Margaret Sällberg Chen

doi: 10.1136/gutjnl-2018-317458

March 12, 2019

PostScript
Most unambiguous loss-of-function CPA1 mutations are unlikely to predispose to chronic pancreatitis

Jin-Huan Lin, Arnaud Boulling, Emmanuelle Masson, David N Cooper, Zhao-Shen Li, Claude Férec, Zhuan Liao, Jian-Min Chen

doi: 10.1136/gutjnl-2019-318564

March 11, 2019

Endoscopy
Randomised controlled trial of WISENSE, a real-time quality improving system for monitoring blind spots during esophagogastroduodenoscopy

Lianlian Wu, Jun Zhang, Wei Zhou, Ping An, Lei Shen, Jun Liu, Xiaoda Jiang, Xu Huang, Ganggang Mu, Xinyue Wan, Xiaoguang Lv, Juan Gao, Ning Cui, Shan Hu, Yiyun Chen, Xiao Hu, Jiangjie Li, Di Chen, Dexin Gong, Xinqi He, Qianshan Ding, Xiaoyun Zhu, Suqin Li, Xiao Wei, Xia Li, Xuemei Wang, Jie Zhou, Mengjiao Zhang, Hong Gang Yu

doi: 10.1136/gutjnl-2018-317366

March 09, 2019

Oesophagus
Immune activation by DNA damage predicts response to chemotherapy and survival in oesophageal adenocarcinoma

Richard C Turkington, Laura A Knight, Jaine K Blayney, Maria Secrier, Rosalie Douglas, Eileen E Parkes, Eilis K Sutton, Leanne Stevenson, Damian McManus, Sophia Halliday, Andrena M McCavigan, Gemma E Logan, Steven M Walker, Christopher J Steele, Juliane Perner, Jan Bornschein, Shona MacRae, Ahmad Miremadi, Eamon McCarron, Stephen McQuaid, Kenneth Arthur, Jacqueline A James, Martin M Eatock, Robert O’Neill, Fergus Noble, Timothy J Underwood, D Paul Harkin, Manuel Salto-Tellez, Rebecca C Fitzgerald, Richard D Kennedy on behalf of the Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group

doi: 10.1136/gutjnl-2018-317624

March 08, 2019

Pancreas
GABRP regulates chemokine signalling, macrophage recruitment and tumour progression in pancreatic cancer through tuning KCNN4-mediated Ca²⁺ signalling in a GABA-independent manner

Shu-Heng Jiang, Li-Li Zhu, Man Zhang, Rong-Kun Li, Qin Yang, Jiang-Yu Yan, Ce Zhang, Jian-Yu Yang, Fang-Yuan Dong, Miao Dai, Li-Peng Hu, Jun Li, Qing Li, Ya-Hui Wang, Xiao-Mei Yang, Yan-Li Zhang, Hui-Zhen Nie, Lei Zhu, Xue-Li Zhang, Guang-Ang Tian, Xiao-Xin Zhang, Xiao-Yan Cao, Ling-Ye Tao, Shan Huang, Yong-Sheng Jiang, Rong Hua, Kathy Qian Luo, Jian-Ren Gu, Yong-Wei Sun, Shangwei Hou, Zhi-Gang Zhang

doi: 10.1136/gutjnl-2018-317479

March 06, 2019

Gut microbiota
Gut mucosal virome alterations in ulcerative colitis

Tao Zuo, Xiao-Juan Lu, Yu Zhang, Chun Pan Cheung, Siu Lam, Fen Zhang, Whitney Tang, Jessica Y L Ching, Risheng Zhao, Paul K S Chan, Joseph J Y Sung, Jun Yu, Francis K L Chan, Qian Cao, Jian-Qiu Sheng, Siew C Ng

doi: 10.1136/gutjnl-2018-318131
Stomach
Diverse tumour susceptibility in Collaborative Cross mice: identification of a new mouse model for human gastric tumourigenesis

Pin Wang, Yunshan Wang, Sasha A Langley, Yan-Xia Zhou, Kuang-Yu Jen, Qi Sun, Colin Brislawn, Carolina M Rojas, Kimberly L Wahl, Ting Wang, Xiangshan Fan, Janet K Jansson, Susan E Celniker, Xiaoping Zou, David W Threadgill, Antoine M Snijders, Jian-Hua Mao

doi: 10.1136/gutjnl-2018-316691

March 04, 2019

Hepatology
Combined small molecule and loss-of-function screen uncovers estrogen receptor alpha and CAD as host factors for HDV infection and antiviral targets

Eloi R Verrier, Amélie Weiss, Charlotte Bach, Laura Heydmann, Vincent Turon-Lagot, Arnaud Kopp, Houssein El Saghire, Emilie Crouchet, Patrick Pessaux, Thomas Garcia, Patrick Pale, Mirjam B Zeisel, Camille Sureau, Catherine Schuster, Laurent Brino, Thomas F Baumert

doi: 10.1136/gutjnl-2018-317065

March 03, 2019

GI cancer
Genomic ERBB2/ERBB3 mutations promote PD-L1-mediated immune escape in gallbladder cancer: a whole-exome sequencing analysis

Maolan Li, Fatao Liu, Fei Zhang, Weiping Zhou, Xiaoqing Jiang, Yuan Yang, Kai Qu, Yueqi Wang, Qiang Ma, Ting Wang, Lu Bai, Zheng Wang, Xiaoling Song, Yidi Zhu, Ruiyan Yuan, Yuan Gao, Yongchen Liu, Yunpeng Jin, Huaifeng Li, Shanshan Xiang, Yuanyuan Ye, Yijian Zhang, Lin Jiang, Yunping Hu, Yajuan Hao, Wei Lu, Shili Chen, Jun Gu, Jian Zhou, Wei Gong, Yong Zhang, Xuefeng Wang, Xiyong Liu, Chang Liu, Houbao Liu, Yun Liu, Yingbin Liu

doi: 10.1136/gutjnl-2018-316039

March 02, 2019

Correction
Correction: Comprehensive characterisation ofcompartment-specific long non-coding RNAs associated with pancreatic ductaladenocarcinoma
Free

doi: 10.1136/gutjnl-2017-314353corr1
Commentary
Diverticular disease: picking pockets and population biobanks

Rinse K Weersma, Miles Parkes

doi: 10.1136/gutjnl-2019-318231

February 28, 2019

Pancreas
Experimental microdissection enables functional harmonisation of pancreatic cancer subtypes

Carlo Maurer, Sam R Holmstrom, Jing He, Pasquale Laise, Tao Su, Aqeel Ahmed, Hanina Hibshoosh, John A Chabot, Paul E Oberstein, Antonia R Sepulveda, Jeanine M Genkinger, Jiapeng Zhang, Alina C Iuga, Mukesh Bansal, Andrea Califano, Kenneth P Olive

doi: 10.1136/gutjnl-2018-317706

February 27, 2019

Commentary
A tangled tale of molecular subtypes in pancreatic cancer

Shiv Singh, Marie Christin Hasselluhn, Albrecht Neesse

doi: 10.1136/gutjnl-2018-318086
Endoscopy
Real-time automatic detection system increases colonoscopic polyp and adenoma detection rates: a prospective randomised controlled study

Pu Wang, Tyler M Berzin, Jeremy Romek Glissen Brown, Shishira Bharadwaj, Aymeric Becq, Xun Xiao, Peixi Liu, Liangping Li, Yan Song, Di Zhang, Yi Li, Guangre Xu, Mengtian Tu, Xiaogang Liu

doi: 10.1136/gutjnl-2018-317500

February 26, 2019

PostScript
Depression in inflammatory bowel disease: risk factor, prodrome or extraintestinal manifestation?

Calum D Moulton, Christine Norton, Nick Powell, Zahra Mohamedali, Christopher W P Hopkins

doi: 10.1136/gutjnl-2019-318444
PostScript
Reducing the number of surveillance colonoscopies with faecal immunochemical tests

Erin L Symonds, Kathryn Cornthwaite, Robert J L Fraser, Peter Bampton, Charles Cock, Graeme P Young

doi: 10.1136/gutjnl-2019-318370
Colon
Statins reduce the progression of non-advanced adenomas to colorectal cancer: a postcolonoscopy study in 187 897 patients

Ka-Shing Cheung, Lijia Chen, Esther W Chan, Wai-Kay Seto, Ian C K Wong, Wai K Leung

doi: 10.1136/gutjnl-2018-317714

February 22, 2019

Recent advances in basic science
Messenger RNA therapy for rare genetic metabolic diseases

Pedro Berraondo, Paolo G V Martini, Matias A Avila, Antonio Fontanellas

doi: 10.1136/gutjnl-2019-318269
PostScript
Response to the letter: Identification of trimethylamine N-oxide (TMAO)-producer phenotype is interesting, but is it helpful?

Wei-Kai Wu, Lee-Yan Sheen, Ming-Shiang Wu

doi: 10.1136/gutjnl-2018-318187

February 21, 2019

Inflammatory bowel disease
T cell clonal expansions in ileal Crohn’s disease are associated with smoking behaviour and postoperative recurrence

Matthieu Allez, Claire Auzolle, Marjolaine Ngollo, Hugo Bottois, Victor Chardiny, Ana Maria Corraliza, Azucena Salas, Kevin Perez, Carmen Stefanescu, Stéphane Nancey, Anthony Buisson, Benjamin Pariente, Mathurin Fumery, Harry Sokol, Xavier Tréton, Nicolas Barnich, Philippe Seksik, Lionel Le Bourhis REMIND Study Group

doi: 10.1136/gutjnl-2018-317878
PostScript
Changing trends in coding for depression among the UK IBD population: reply from authors

Isabelle Vallerand, Alexandra D Frolkis, Scott Patten, Gilaad G Kaplan

doi: 10.1136/gutjnl-2019-318405
Guidelines
Diagnosis and management of acute lower gastrointestinal bleeding: guidelines from the British Society of Gastroenterology

Kathryn Oakland, Georgina Chadwick, James E East, Richard Guy, Adam Humphries, Vipul Jairath, Simon McPherson, Magdalena Metzner, A John Morris, Mike F Murphy, Tony Tham, Raman Uberoi, Andrew McCulloch Veitch, James Wheeler, Cuthbert Regan, Jonathan Hoare

doi: 10.1136/gutjnl-2018-317807

February 19, 2019

Gut microbiota
Effects of dietary fat on gut microbiota and faecal metabolites, and their relationship with cardiometabolic risk factors: a 6-month randomised controlled-feeding trial

Yi Wan, Fenglei Wang, Jihong Yuan, Jie Li, Dandan Jiang, Jingjing Zhang, Hao Li, Ruoyi Wang, Jun Tang, Tao Huang, Jusheng Zheng, Andrew J Sinclair, Jim Mann, Duo Li

doi: 10.1136/gutjnl-2018-317609

February 16, 2019

Endoscopy news
Concept of disposable duodenoscope: at what cost?

Ji Young Bang, Bryce Sutton, Robert Hawes, Shyam Varadarajulu

doi: 10.1136/gutjnl-2019-318227
Pancreas
Beta-cell sensitivity to insulinotropic gut hormones is reduced after gastric bypass surgery

Marzieh Salehi, Amalia Gastaldelli, David A D’Alessio

doi: 10.1136/gutjnl-2018-317760

February 13, 2019

PostScript
Changing trends in coding for depression among the UK inflammatory bowel disease population

Jonathan Blackwell, Sonia Saxena, Richard C Pollok

doi: 10.1136/gutjnl-2019-318296
PostScript
Case of IgG4-associated sclerosing cholangitis with normal serum IgG4 concentration, diagnosed by anti-laminin 511-E8 antibody: a novel autoantibody in patients with autoimmune pancreatitis

Yukari Kato, Keishiro Azuma, Hitoshi Someda, Masahiro Shiokawa, Tsutomu Chiba

doi: 10.1136/gutjnl-2018-317934

February 12, 2019

PostScript
Treatment for Helicobacter pylori appears to reduce the incidence of gastric cancer: eradication effect or screening effect?

Yutaka Yamaji, Yoshihiro Hirata

doi: 10.1136/gutjnl-2018-318206

February 11, 2019

Inflammatory bowel disease
Cost-effectiveness of laparoscopic ileocaecal resection versus infliximab treatment of terminal ileitis in Crohn’s disease: the LIR!C Trial

E Joline de Groof, Toer W Stevens, Emma J Eshuis, Tjibbe J Gardenbroek, Judith E Bosmans, JM van Dongen, Bregje Mol, Christianne J Buskens, Pieter C F Stokkers, Ailsa Hart, Geert R D’Haens, Willem A Bemelman, Cyriel Y Ponsioen on behalf of the LIR!C study group

doi: 10.1136/gutjnl-2018-317539
Pancreas
STING signalling protects against chronic pancreatitis by modulating Th17 response

Qinglan Zhao, Murli Manohar, Yi Wei, Stephen J Pandol, Aida Habtezion

doi: 10.1136/gutjnl-2018-317098
PostScript
Duration of organ failure impacts mortality in acute pancreatitis

Na Shi, Tingting Liu, Daniel de la Iglesia-Garcia, Lihui Deng, Tao Jin, Lan Lan, Ping Zhu, Weiming Hu, Zongguang Zhou, Vikesh Singh, J Enrique Dominguez-Munoz, John Windsor, Wei Huang, Qing Xia, Robert Sutton

doi: 10.1136/gutjnl-2019-318241
Gut microbiota
Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection

Benjamin H Mullish, Julie A K McDonald, Alexandros Pechlivanis, Jessica R Allegretti, Dina Kao, Grace F Barker, Diya Kapila, Elaine O Petrof, Susan A Joyce, Cormac G M Gahan, Izabela Glegola-Madejska, Horace R T Williams, Elaine Holmes, Thomas B Clarke, Mark R Thursz, Julian R Marchesi

doi: 10.1136/gutjnl-2018-317842

February 05, 2019

Hepatology
TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function

Grégory Merlen, Nicolas Kahale, Jose Ursic-Bedoya, Valeska Bidault-Jourdainne, Hayat Simerabet, Isabelle Doignon, Zahra Tanfin, Isabelle Garcin, Noémie Péan, Julien Gautherot, Anne Davit-Spraul, Catherine Guettier, Lydie Humbert, Dominique Rainteau, Klaus Ebnet, Christoph Ullmer, Doris Cassio, Thierry Tordjmann

doi: 10.1136/gutjnl-2018-316975
PostScript
Microscopic heterogeneity in ulcerative colitis: implications for microscopic measurement of disease activity

Noam Harpaz, Samuel Ballentine, Jean-Frederic Colombel, Bruce E Sands, Huabin Mabel Ko

doi: 10.1136/gutjnl-2018-318137

February 02, 2019

GI cancer
RSPO2 gene rearrangement: a powerful driver of β-catenin activation in liver tumours

Thomas Longerich, Volker Endris, Olaf Neumann, Eugen Rempel, Martina Kirchner, Zahra Abadi, Sebastian Uhrig, Mark Kriegsmann, Karl Heinz Weiss, Kai Breuhahn, Arianeb Mehrabi, Tim Frederik Weber, Ludwig Wilkens, Beate K Straub, Andreas Rosenwald, Falko Schulze, Benedikt Brors, Stefan Froehling, Rossella Pellegrino, Jan Budczies, Peter Schirmacher, Albrecht Stenzinger

doi: 10.1136/gutjnl-2018-317632
Hepatology
Dysregulated activation of fetal liver programme in acute liver failure

Jeongeun Hyun, Seh-Hoon Oh, Richard T Premont, Cynthia D Guy, Carl L Berg, Anna Mae Diehl

doi: 10.1136/gutjnl-2018-317603
Colon
Endoscopic scar assessment after colorectal endoscopic mucosal resection scars: when is biopsy necessary (EMR Scar Assessment Project for Endoscope (ESCAPE) trial)

Pujan Kandel, Eelco Christiaan Brand, Joe Pelt, Colleen T Ball, Wei-Chung Chen, Ernest P Bouras, Victoria Gomez, Massimo Raimondo, Timothy A Woodward, Michael B Wallace the EMR SCAR Group

doi: 10.1136/gutjnl-2018-316574

February 01, 2019

Editor’s quiz: GI snapshot
Occult gastrointestinal bleeding: two eyes are better than one

Samuel Pannick, Katherine van Ree, Patrizia Cohen, Geoff Smith, John Martin

doi: 10.1136/gutjnl-2018-318095
Gut microbiota
Antibiotics-induced monodominance of a novel gut bacterial order

Falk Hildebrand, Lucas Moitinho-Silva, Sonja Blasche, Martin T Jahn, Toni Ingolf Gossmann, Jaime Huerta-Cepas, Rajna Hercog, Mechthild Luetge, Mohammad Bahram, Anna Pryszlak, Renato J Alves, Sebastian M Waszak, Ana Zhu, Lumeng Ye, Paul Igor Costea, Steven Aalvink, Clara Belzer, Sofia K Forslund, Shinichi Sunagawa, Ute Hentschel, Christoph Merten, Kiran Raosaheb Patil, Vladimir Benes, Peer Bork

doi: 10.1136/gutjnl-2018-317715

January 30, 2019

Editor’s quiz: GI snapshot
Nutmeg liver, fever and elevated liver enzymes in a young man

Aleksandar Gavrić, Rok Dežman, Branislava Ranković, Marija Ribnikar, Borut Štabuc

doi: 10.1136/gutjnl-2018-318099
Hepatology
HBV infection-induced liver cirrhosis development in dual-humanised mice with human bone mesenchymal stem cell transplantation

Lunzhi Yuan, Jing Jiang, Xuan Liu, Yali Zhang, Liang Zhang, Jiaojiao Xin, Kun Wu, Xiaoling Li, Jiali Cao, Xueran Guo, Dongyan Shi, Jun Li, Longyan Jiang, Suwan Sun, Tengyun Wang, Wangheng Hou, Tianying Zhang, Hua Zhu, Jun Zhang, Quan Yuan, Tong Cheng, Jun Li, Ningshao Xia

doi: 10.1136/gutjnl-2018-316091

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