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BMJ Journals More

Online First

September 21, 2019

GI cancer
Integrated paired-end enhancer profiling and whole-genome sequencing reveals recurrent CCNE1 and IGF2 enhancer hijacking in primary gastric adenocarcinoma

Wen Fong Ooi, Amrita M Nargund, Kevin Junliang Lim, Shenli Zhang, Manjie Xing, Amit Mandoli, Jing Quan Lim, Shamaine Wei Ting Ho, Yu Guo, Xiaosai Yao, Suling Joyce Lin, Tannistha Nandi, Chang Xu, Xuewen Ong, Minghui Lee, Angie Lay-Keng Tan, Yue Ning Lam, Jing Xian Teo, Atsushi Kaneda, Kevin P White, Weng Khong Lim, Steven G Rozen, Bin Tean Teh, Shang Li, Anders J Skanderup, Patrick Tan

doi: 10.1136/gutjnl-2018-317612
Editor’s quiz: GI snapshot
Duodenal and liver lesions in an adult with generalised weakness

David Szafron, Hyun-seok Kim, Christie G Turin, Eduardo Benzi, Natalia Khalaf, Ruben Hernaez

doi: 10.1136/gutjnl-2019-319561

September 20, 2019

Endoscopy news
Real-time use of artificial intelligence in the evaluation of cancer in Barrett’s oesophagus

Alanna Ebigbo, Robert Mendel, Andreas Probst, Johannes Manzeneder, Friederike Prinz, Luis A de Souza Jr., Joao Papa, Christoph Palm, Helmut Messmann

doi: 10.1136/gutjnl-2019-319460
Inflammatory bowel disease
Anti-TNF therapy in IBD exerts its therapeutic effect through macrophage IL-10 signalling

Pim J Koelink, Felicia M Bloemendaal, Bofeng Li, Liset Westera, Esther W M Vogels, Manon van Roest, Anouk K Gloudemans, Angelique B van 't Wout, Hannelie Korf, Séverine Vermeire, Anje A te Velde, Cyriel Y Ponsioen, Geert RAM D'Haens, J Sjef Verbeek, Terrence L Geiger, Manon E Wildenberg, Gijs R van den Brink

doi: 10.1136/gutjnl-2019-318264

September 18, 2019

PostScript
Mortality rate after pneumatic dilatation for achalasia: authors’ reply

Philip R Harvey, Prashant Patel, Nigel J Trudgill

doi: 10.1136/gutjnl-2019-319762
Endoscopy News
Quantitative fluorescence endoscopy: an innovative endoscopy approach to evaluate neoadjuvant treatment response in locally advanced rectal cancer

Jolien J J Tjalma, Marjory Koller, Matthijs D Linssen, Elmire Hartmans, Steven de Jongh, Annelies Jorritsma-Smit, Arend Karrenbeld, Elisabeth G de Vries, Jan H Kleibeuker, Jan Pieter Pennings, Klaas Havenga, Patrick HJH Hemmer, Geke AP Hospers, Boudewijn van Etten, Vasilis Ntziachristos, Gooitzen M van Dam, Dominic J Robinson, Wouter B Nagengast

doi: 10.1136/gutjnl-2019-319755

September 17, 2019

Pancreas
Whole-genome sequencing reveals distinct genetic bases for insulinomas and non-functional pancreatic neuroendocrine tumours: leading to a new classification system

Xiafei Hong, Sitan Qiao, Fuqiang Li, Wenze Wang, Rui Jiang, Huanwen Wu, Hao Chen, Lulu Liu, Junya Peng, Jing Wang, Congwei Jia, Xiaolong Liang, Hongmei Dai, Jialin Jiang, Taiping Zhang, Quan Liao, Menghua Dai, Lin Cong, Xianlin Han, Dan Guo, Zhiyong Liang, Dongjing Li, Zetian Zheng, Chen Ye, Siliang Li, Yupei Zhao, Kui Wu, Wenming Wu

doi: 10.1136/gutjnl-2018-317233
Hepatology
Rilpivirine attenuates liver fibrosis through selective STAT1-mediated apoptosis in hepatic stellate cells

Alberto Martí-Rodrigo, Fernando Alegre, Ángela B Moragrega, Francisco García-García, Pablo Martí-Rodrigo, Anabel Fernández-Iglesias, Jordi Gracia-Sancho, Nadezda Apostolova, Juan V Esplugues, Ana Blas-García

doi: 10.1136/gutjnl-2019-318372

September 16, 2019

Commentary
Nucleos(t)ide analogues in patients with chronic hepatitis B: to stop or not to stop?

Jia-Horng Kao, Thomas Berg

doi: 10.1136/gutjnl-2019-319648

September 13, 2019

Hepatology
CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma

Cun Wang, Hui Wang, Cor Lieftink, Aimee du Chatinier, Dongmei Gao, Guangzhi Jin, Haojie Jin, Roderick L Beijersbergen, Wenxin Qin, René Bernards

doi: 10.1136/gutjnl-2019-318506

September 11, 2019

PostScript
Scoring endoscopic disease activity in IBD: artificial intelligence sees more and better than we do

Peter Bossuyt, Séverine Vermeire, Raf Bisschops

doi: 10.1136/gutjnl-2019-318235
Hepatology
Limited sustained response after stopping nucleos(t)ide analogues in patients with chronic hepatitis B: results from a randomised controlled trial (Toronto STOP study)

Kin Seng Liem, Scott Fung, David K Wong, Colina Yim, Seham Noureldin, Jiayun Chen, Jordan J Feld, Bettina E Hansen, Harry L A Janssen

doi: 10.1136/gutjnl-2019-318981

September 10, 2019

PostScript
British Society of Gastroenterology position statement on patient experience of GI endoscopy

Colin J Rees, Tim M Trebble, Christian Von Wagner, Zoe Clapham, Paul Hewitson, Hugh Barr, Simon Everett, Helen Griffiths, Manu Nayar, Kofi Oppong, Stuart Riley, John Stebbing, Siwan Thomas-Gibson, Roisin Bevan

doi: 10.1136/gutjnl-2019-319207
PostScript
Alcohol-dependent effect of PRSS1-PRSS2 haplotype in chronic pancreatitis

Eszter Hegyi, Anna Zsófia Tóth, Áron Vincze, Andrea Szentesi, Péter Hegyi, Miklós Sahin-Tóth

doi: 10.1136/gutjnl-2019-319729

September 07, 2019

Inflammatory bowel disease
ZEB1 promotes inflammation and progression towards inflammation-driven carcinoma through repression of the DNA repair glycosylase MPG in epithelial cells

Oriol de Barrios, Lidia Sanchez-Moral, Marlies Cortés, Chiara Ninfali, Nuria Profitós-Pelejà, MC Martínez-Campanario, Laura Siles, Rosa del Campo, María Jesús Fernández-Aceñero, Douglas S Darling, Antoni Castells, Joan Maurel, Azucena Salas, Douglas C Dean, Antonio Postigo

doi: 10.1136/gutjnl-2018-317294

September 06, 2019

PostScript
Dietary fat and the faecal microbiome: where collinearity may lead to incorrect attribution of effects to fat

Zaid S Ardalan, Miles P Sparrow, Jane G Muir, Peter R Gibson

doi: 10.1136/gutjnl-2019-319628

September 05, 2019

GI cancer
Global patterns and trends in colorectal cancer incidence in young adults

Rebecca L Siegel, Lindsey A Torre, Isabelle Soerjomataram, Richard B Hayes, Freddie Bray, Thomas K Weber, Ahmedin Jemal

doi: 10.1136/gutjnl-2019-319511

September 03, 2019

PostScript
The prescreening tool for gastric cancer in China

Kecheng Liu, Mengbin Qin, Jiean Huang

doi: 10.1136/gutjnl-2019-319591
PostScript
ESD, not EMR, should be the first-line therapy for early gastric neoplasia

Neal Shahidi, Michael J Bourke

doi: 10.1136/gutjnl-2019-319646
GI cancer
Single-cell transcriptional analyses of spasmolytic polypeptide-expressing metaplasia arising from acute drug injury and chronic inflammation in the stomach

Kevin A Bockerstett, Scott A Lewis, Kyle J Wolf, Christine N Noto, Nicholas M Jackson, Eric L Ford, Tae-Hyuk Ahn, Richard J DiPaolo

doi: 10.1136/gutjnl-2019-318930

August 31, 2019

PostScript
There is much more to rely on histology than the sole endoscopy tells us

Matteo Ghisa, Massimo Rugge, Matteo Fassan, Fabio Farinati, Edoardo Savarino

doi: 10.1136/gutjnl-2019-319649

August 30, 2019

Gut microbiota
Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer’s disease animal model

Min-Soo Kim, Yoonhee Kim, Hyunjung Choi, Woojin Kim, Sumyung Park, Dongjoon Lee, Dong Kyu Kim, Haeng Jun Kim, Hayoung Choi, Dong-Wook Hyun, June-Young Lee, Eun Young Choi, Dong-Sup Lee, Jin-Woo Bae, Inhee Mook-Jung

doi: 10.1136/gutjnl-2018-317431
Hepatology
Quasispecies characteristic in “a” determinant region is a potential predictor for the risk of immunoprophylaxis failure of mother-to-child-transmission of sub-genotype C2 hepatitis B virus: a prospective nested case–control study

Yiwei Xiao, Kuixia Sun, Zhongping Duan, Zhixiu Liu, Yi Li, Ling Yan, Yarong Song, Huaibin Zou, Hui Zhuang, Jie Wang, Jie Li

doi: 10.1136/gutjnl-2019-318278

August 28, 2019

Coeliac disease
Characterisation of clinical and immune reactivity to barley and rye ingestion in children with coeliac disease

Melinda Y Hardy, Amy K Russell, Catherine Pizzey, Claerwen M Jones, Katherine A Watson, Nicole L La Gruta, Donald J Cameron, Jason A Tye-Din

doi: 10.1136/gutjnl-2019-319093

August 27, 2019

GI cancer
Faecal haemoglobin concentration among subjects with negative FIT results is associated with the detection rate of neoplasia at subsequent rounds: a prospective study in the context of population based screening programmes in Italy

Carlo Senore, Marco Zappa, Cinzia Campari, Sergio Crotta, Paola Armaroli, Arrigo Arrigoni, Paola Cassoni, Rossana Colla, Mario Fracchia, Fabrizio Gili, Grazia Grazzini, Roberto Lolli, Patrizia Menozzi, Lorenzo Orione, Salvatore Polizzi, Stefano Rapi, Emilia Riggi, Tiziana Rubeca, Romano Sassatelli, Carmen Visioli, Nereo Segnan

doi: 10.1136/gutjnl-2018-318198

August 24, 2019

Inflammatory bowel disease
Risk of acute arterial events associated with treatment of inflammatory bowel diseases: nationwide French cohort study

Julien Kirchgesner, Nynne Nyboe Andersen, Fabrice Carrat, Tine Jess, Laurent Beaugerie BERENICE study group

doi: 10.1136/gutjnl-2019-318932

August 22, 2019

Hepatology
Histone chaperone FACT complex mediates oxidative stress response to promote liver cancer progression

Jialing Shen, Mengnuo Chen, Derek Lee, Cheuk-Ting Law, Lai Wei, Felice Ho-Ching Tsang, Don Wai-Ching Chin, Carol Lai-Hung Cheng, Joyce Man-Fong Lee, Irene Oi-Lin Ng, Carmen Chak-Lui Wong, Chun-Ming Wong

doi: 10.1136/gutjnl-2019-318668

August 20, 2019

Editor’s quiz: GI snapshot
A polypoidal ‘non-polyp’ in the colon

John Joseph McGoran, Sudarshan R Kadri, Catherine Moreman, Peter Wurm

doi: 10.1136/gutjnl-2019-319581

August 19, 2019

Gut microbiota
Oral antibiotic use and risk of colorectal cancer in the United Kingdom, 1989–2012: a matched case–control study

Jiajia Zhang, Charles Haines, Alastair J M Watson, Andrew R Hart, Mary Jane Platt, Drew M Pardoll, Sara E Cosgrove, Kelly A Gebo, Cynthia L Sears

doi: 10.1136/gutjnl-2019-318593
Recent advances in clinical practice
Update on lactose malabsorption and intolerance: pathogenesis, diagnosis and clinical management

Benjamin Misselwitz, Matthias Butter, Kristin Verbeke, Mark R Fox

doi: 10.1136/gutjnl-2019-318404

August 17, 2019

Inflammatory bowel disease
Imbalance of the renin–angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?

Mayur Garg, Simon G Royce, Chris Tikellis, Claire Shallue, Duygu Batu, Elena Velkoska, Louise M Burrell, Sheila K Patel, Lauren Beswick, Anvesh Jackson, Kaushali Britto, Matthew Lukies, Pavel Sluka, Hady Wardan, Yumiko Hirokawa, Chin Wee Tan, Maree Faux, Antony W Burgess, Patrick Hosking, Shaun Monagle, Merlin Thomas, Peter R Gibson, John Lubel

doi: 10.1136/gutjnl-2019-318512
Stomach
Meta-analysis of genome-wide association studies and functional assays decipher susceptibility genes for gastric cancer in Chinese populations

Caiwang Yan, Meng Zhu, Yanbing Ding, Ming Yang, Mengyun Wang, Gang Li, Chuanli Ren, Tongtong Huang, Wenjun Yang, Bangshun He, Meilin Wang, Fei Yu, Jinchen Wang, Ruoxin Zhang, Tianpei Wang, Jing Ni, Jiaping Chen, Yue Jiang, Juncheng Dai, Erbao Zhang, Hongxia Ma, Yanong Wang, Dazhi Xu, Shukui Wang, Yun Chen, Zekuan Xu, Jianwei Zhou, Guozhong Ji, Zhaoming Wang, Zhengdong Zhang, Zhibin Hu, Qingyi Wei, Hongbing Shen, Guangfu Jin

doi: 10.1136/gutjnl-2019-318760

August 14, 2019

Endoscopy News
The hidden cost of colonoscopy including cost of reprocessing and infection rate: the implications for disposable colonoscopes

Sara Larsen, Anthony Kalloo, Susan Hutfless

doi: 10.1136/gutjnl-2019-319108
PostScript
Intestinal resection rates in Crohn’s disease decline across two different epidemiological areas: a consistent observation not merely due to introduction of anti-TNFα

Evelien M J Beelen, C Janneke van der Woude, Annemarie C de Vries

doi: 10.1136/gutjnl-2019-319321
Inflammatory bowel disease
IBD prevalence in Lothian, Scotland, derived by capture–recapture methodology

Gareth-Rhys Jones, Mathew Lyons, Nikolas Plevris, Philip W Jenkinson, Cathy Bisset, Christopher Burgess, Shahida Din, James Fulforth, Paul Henderson, Gwo-Tzer Ho, Kathryn Kirkwood, Colin Noble, Alan G Shand, David C Wilson, Ian DR Arnott, Charlie W Lees

doi: 10.1136/gutjnl-2019-318936

August 13, 2019

Hepatology
Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury

Yuan Zhuang, Haifeng C Xu, Prashant V Shinde, Jens Warfsmann, Jelena Vasilevska, Balamurugan Sundaram, Kristina Behnke, Jun Huang, Jessica I Hoell, Arndt Borkhardt, Klaus Pfeffer, Mohamed S Taha, Diran Herebian, Ertan Mayatepek, Dirk Brenner, Mohammad Reza Ahmadian, Verena Keitel, Dagmar Wieczorek, Dieter Häussinger, Aleksandra A Pandyra, Karl S Lang, Philipp A Lang

doi: 10.1136/gutjnl-2019-318215
GI cancer
Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in oesophageal adenocarcinoma

Li Chen, Moli Huang, Jasmine Plummer, Jian Pan, Yan Yi Jiang, Qian Yang, Tiago Chedraoui Silva, Nicole Gull, Stephanie Chen, Ling Wen Ding, Omer An, Henry Yang, Yulan Cheng, Jonathan W Said, Ngan Doan, Winand NM Dinjens, Kevin M Waters, Richard Tuli, Simon A Gayther, Samuel J Klempner, Benjamin P Berman, Stephen J Meltzer, De-Chen Lin, H Phillip Koeffler

doi: 10.1136/gutjnl-2019-318325
Oesophagus
Phase III, randomised, double-blind, multicentre study to evaluate the efficacy and safety of vonoprazan compared with lansoprazole in Asian patients with erosive oesophagitis

Yinglian Xiao, Shutian Zhang, Ning Dai, Guijun Fei, Khean-Lee Goh, Hoon Jai Chun, Bor-Shyang Sheu, Chui Fung Chong, Nobuo Funao, Wen Zhou, Minhu Chen

doi: 10.1136/gutjnl-2019-318365

August 10, 2019

Hepatology
Novel strategy for oral peptide delivery in incretin-based diabetes treatment

Yining Xu, Matthias Van Hul, Francesco Suriano, Véronique Préat, Patrice D Cani, Ana Beloqui

doi: 10.1136/gutjnl-2019-319146

August 09, 2019

Oesophagus
Immune activation by DNA damage predicts response to chemotherapy and survival in oesophageal adenocarcinoma

Richard C Turkington, Laura A Knight, Jaine K Blayney, Maria Secrier, Rosalie Douglas, Eileen E Parkes, Eilis K Sutton, Leanne Stevenson, Damian McManus, Sophia Halliday, Andrena M McCavigan, Gemma E Logan, Steven M Walker, Christopher J Steele, Juliane Perner, Jan Bornschein, Shona MacRae, Ahmad Miremadi, Eamon McCarron, Stephen McQuaid, Kenneth Arthur, Jacqueline A James, Martin M Eatock, Robert O’Neill, Fergus Noble, Timothy J Underwood, D Paul Harkin, Manuel Salto-Tellez, Rebecca C Fitzgerald, Richard D Kennedy on behalf of the Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group

doi: 10.1136/gutjnl-2018-317624
Endoscopy News
Case of early Barrett cancer following peroral endoscopic myotomy

Yervant Ichkhanian, Petros Benias, Mouen A Khashab

doi: 10.1136/gutjnl-2019-318950

August 08, 2019

PostScript
Management of acute lower gastrointestinal bleeding: evidence based medicine? Authors’ reply

Kathryn Oakland, Jonathan Hoare

doi: 10.1136/gutjnl-2019-319525

August 07, 2019

Commentary
New warning signs on the road: 5-hydroxymethylcytosine-based liquid biopsy for the early detection of hepatocellular carcinoma

Maria Arechederra

doi: 10.1136/gutjnl-2019-319339

August 05, 2019

PostScript
Response to the recently published guidelines on lower gastrointestinal bleeding

Samuel Snelling, Rania Ghaffar, Stephen Thomas Ward

doi: 10.1136/gutjnl-2019-319515
PostScript
Mortality rate after pneumatic dilatation for achalasia

Froukje B van Hoeij, Albert J Bredenoord

doi: 10.1136/gutjnl-2019-319513

August 02, 2019

Commentary
Getting insights into hepatocellular carcinoma tumour heterogeneity by multiomics dissection

Pablo Sarobe, Fernando Corrales

doi: 10.1136/gutjnl-2019-319410
PostScript
First known case of paediatric inflammatory bowel disease in a western lowland gorilla may be linked to a familial mutation in the MEFV gene

Britt-Sabina Petersen, Bernd Bokemeyer, Christian Wenker, Stefan Hoby, Katrin Baumgartner, Hermann Will, Marc P Hoeppner, Stefan Schreiber, Ingo Mecklenburg, Andre Franke

doi: 10.1136/gutjnl-2019-319051
Oesophagus
How to select patients for antireflux surgery? The ICARUS guidelines (international consensus regarding preoperative examinations and clinical characteristics assessment to select adult patients for antireflux surgery)

Ans Pauwels, Veerle Boecxstaens, Christopher N Andrews, Stephen E Attwood, Richard Berrisford, Raf Bisschops, Guy E Boeckxstaens, Serhat Bor, Albert J Bredenoord, Michele Cicala, Maura Corsetti, Fernando Fornari, Chandra Prakash Gyawali, Jan Hatlebakk, Scott B Johnson, Toni Lerut, Lars Lundell, Sandro Mattioli, Hiroto Miwa, Philippe Nafteux, Taher Omari, John Pandolfino, Roberto Penagini, Thomas W Rice, Philip Roelandt, Nathalie Rommel, Vincenzo Savarino, Daniel Sifrim, Hidekazu Suzuki, Radu Tutuian, Tim Vanuytsel, Marcelo F Vela, David I Watson, Frank Zerbib, Jan Tack

doi: 10.1136/gutjnl-2019-318260
Hepatology
Adeno-associated virus in the liver: natural history and consequences in tumour development

Tiziana La Bella, Sandrine Imbeaud, Camille Peneau, Iadh Mami, Shalini Datta, Quentin Bayard, Stefano Caruso, Theo Z Hirsch, Julien Calderaro, Guillaume Morcrette, Catherine Guettier, Valerie Paradis, Giuliana Amaddeo, Alexis Laurent, Laurent Possenti, Laurence Chiche, Paulette Bioulac-Sage, Jean-Frederic Blanc, Eric Letouze, Jean-Charles Nault, Jessica Zucman-Rossi

doi: 10.1136/gutjnl-2019-318281
Endoscopy news
Deep-learning based detection of gastric precancerous conditions

Pedro Guimarães, Andreas Keller, Tobias Fehlmann, Frank Lammert, Markus Casper

doi: 10.1136/gutjnl-2019-319347

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