You are here

Article Text

Article menu
Download PDFPDF
Research Article
Genetic studies in human and murine giardiasis.
  1. I C Roberts-Thomson,
  2. G F Mitchell,
  3. R F Anders,
  4. B D Tait,
  5. P Kerlin,
  6. A Kerr-Grant,
  7. P Cavanagh

    Abstract

    Genetic markers were analysed in 48 adults who appeared to have a prolonged infection with Giardia lamblia. The frequency of ABO blood groups, Rhesus blood groups, and Gm phenotypes was similar to that in control subjects. However, there was a higher than expected frequency of HLA antigens A1 (observed 46 . 7%, expected 32%) and B12 (observed 47 . 8%, expected 25 . 8%) and a higher than expected frequency of the phenotypes A1/A2 and B12/B27. Genetic studies were also performed with inbred strains of mice showing relatively rapid (BALB/c) and defective (C3H/He) spontaneous elimination of Giardia muris. From analysis in backcross mice several genes appeared to influence susceptibility to prolonged infection with G. muris.

    https://doi.org/10.1136/gut.21.5.397

    Statistics from Altmetric.com

      Request Permissions

      If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.