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Stomach
Evaluation of laser Doppler flowmetry for the study of benign and malignant gastric blood flow in vivo
  1. M K Schillinga,
  2. C Redaellia,
  3. H Friessa,
  4. B Bluma,
  5. C Signerb,
  6. C A Maurera,
  7. M W Büchlera
  1. aDepartment of Visceral and Transplant Surgery, University of Bern, Inselspital, Bern, Switzerland, bDepartment of Anesthesiology, University of Bern, Inselspital, Bern, Switzerland
  1. Dr M W Büchler, Department of Visceral and Transplant Surgery, University of Bern, Inselspital, CH-3010 Bern, Switzerland.

Abstract

BACKGROUND Tumour vascularisation is a determinant of the development of metastases.

AIMS To measure blood flow in normal stomach and gastric adenocarcinomas by laser Doppler flowmetry and correlate blood flow with vascularisation after immunohistochemical staining of resected specimens for CD31 and von Willebrand factor.

PATIENTS Twenty two undergoing resection for gastric adenocarcinoma and 10 undergoing cholecystectomy.

RESULTS Mean (SD) gastric blood flow was 208 (35) perfusion units (PU) in patients undergoing cholecystectomy and 190 (75) PU in the undiseased part of the stomach in patients with gastric adenocarcinoma. Gastric blood flow was higher in the border of gastric adenocarcinomas (322 (120) PU, p<0.01 v normal stomach) but lower in the centre (74 (27) PU, p<0.01 v normal stomach and tumour border). Blood flow was higher in tumours staged T⩾3 than in those staged T<3. Blood vessel density in normal stomach was 41 (8) stained cells/field viewed and was 1.9–3.4 times higher in gastric adenocarcinomas.

CONCLUSION Laser Doppler flowmetry is a valuable tool for studying the pathophysiological alterations of malignant blood flow in the human stomach in vivo.

  • laser Doppler flowmetry
  • gastric adenocarcinoma
  • angiogenesis
  • CD31
  • von Willebrand factor

  • Abbreviations used in this paper

    PU
    perfusion units
    vWF
    von Willebrand factor

    • https://doi.org/10.1136/gut.45.3.341

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    • Abbreviations used in this paper

      PU
      perfusion units
      vWF
      von Willebrand factor
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